ANXA9 — 56 ClinVar variants
All ClinVar germline ANXA9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
4 Likely benign · 52 Uncertain significance
Full ANXA9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANXA9 p.Ala141Gly Uncertain significance Single submitter
- ANXA9 p.Ala199Ser Uncertain significance Single submitter
- ANXA9 p.Arg252His Uncertain significance Single submitter
- ANXA9 p.Arg295Leu Uncertain significance Single submitter
- ANXA9 p.Arg300Leu Uncertain significance Single submitter
- ANXA9 p.Arg86His Uncertain significance Single submitter
- ANXA9 p.Arg86Leu Uncertain significance Single submitter
- ANXA9 p.Asn251His Uncertain significance Single submitter
- ANXA9 p.Asn251Thr Uncertain significance Single submitter
- ANXA9 p.Asp134Gly Uncertain significance Single submitter
- ANXA9 p.Asp134His Uncertain significance Single submitter
- ANXA9 p.Asp177Asn Uncertain significance Single submitter
- ANXA9 p.Asp304Gly Uncertain significance Single submitter
- ANXA9 p.Gln160Arg Uncertain significance Single submitter
- ANXA9 p.Gly186Ala Uncertain significance Single submitter
- ANXA9 p.Ile54Val Uncertain significance Single submitter
- ANXA9 p.Leu126Pro Uncertain significance Single submitter
- ANXA9 p.Lys127Glu Uncertain significance Single submitter
- ANXA9 p.Met8Val Uncertain significance Single submitter
- ANXA9 p.Met92Ile Uncertain significance Single submitter
- ANXA9 p.Phe316Ser Uncertain significance Single submitter
- ANXA9 p.Pro146Ala Uncertain significance Single submitter
- ANXA9 p.Ser307Asn Uncertain significance Single submitter
- ANXA9 p.Thr4Ala Uncertain significance Single submitter
- ANXA9 p.Val267Ala Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- ANXA9 p.Ala310Asp Uncertain significance Single submitter
- ANXA9 p.Arg239Gly Uncertain significance Single submitter
- ANXA9 p.Arg295Cys Uncertain significance Single submitter
- ANXA9 p.Arg309Thr Uncertain significance Single submitter
- ANXA9 p.Arg313Gly Uncertain significance Single submitter
- ANXA9 p.Arg36Gly Uncertain significance Single submitter
- ANXA9 p.Arg61Cys Uncertain significance Single submitter
- ANXA9 p.Arg71Gln Uncertain significance Single submitter
- ANXA9 p.Arg71Gly Uncertain significance Single submitter
- ANXA9 p.Asp165Tyr Uncertain significance Single submitter
- ANXA9 p.Asp331Tyr Uncertain significance Single submitter
- ANXA9 p.Gln250Pro Uncertain significance Single submitter
- ANXA9 p.Gln84Pro Uncertain significance Single submitter
- ANXA9 p.Gly101Ser Uncertain significance Single submitter
- ANXA9 p.Gly185Arg Uncertain significance Single submitter
- ANXA9 p.Gly192Ala Uncertain significance Single submitter
- ANXA9 p.Gly255Val Uncertain significance Single submitter
- ANXA9 p.Gly30Glu Uncertain significance Single submitter
- ANXA9 p.Ile79Thr Uncertain significance Single submitter
- ANXA9 p.Leu230Val Uncertain significance Single submitter
- ANXA9 p.Leu306Arg Uncertain significance Single submitter
- ANXA9 p.Lys314Asn Uncertain significance Single submitter
- ANXA9 p.Phe312Leu Uncertain significance Single submitter
- ANXA9 p.Pro272Leu Uncertain significance Single submitter
- ANXA9 p.Ser191Tyr Uncertain significance Single submitter
- ANXA9 p.Val135Met Uncertain significance Single submitter
- ANXA9 p.Val59Met Uncertain significance Single submitter
All ANXA9 variants
Likely benign 4
- p.Arg208Gln Single submitter
- p.Gly263Ser Single submitter
- p.Ile137Val Single submitter
- p.Met8Thr Single submitter
Uncertain significance 52
- p.Ala141Gly Single submitter ⚠
- p.Ala199Ser Single submitter ⚠
- p.Ala310Asp Single submitter ⚠
- p.Arg239Gly Single submitter ⚠
- p.Arg252His Single submitter ⚠
- p.Arg295Cys Single submitter ⚠
- p.Arg295Leu Single submitter ⚠
- p.Arg300Leu Single submitter ⚠
- p.Arg309Thr Single submitter ⚠
- p.Arg313Gly Single submitter ⚠
- p.Arg36Gly Single submitter ⚠
- p.Arg61Cys Single submitter ⚠
- p.Arg71Gln Single submitter ⚠
- p.Arg71Gly Single submitter ⚠
- p.Arg86His Single submitter ⚠
- p.Arg86Leu Single submitter ⚠
- p.Asn251His Single submitter ⚠
- p.Asn251Thr Single submitter ⚠
- p.Asp134Gly Single submitter ⚠
- p.Asp134His Single submitter ⚠
- p.Asp165Tyr Single submitter ⚠
- p.Asp177Asn Single submitter ⚠
- p.Asp304Gly Single submitter ⚠
- p.Asp331Tyr Single submitter ⚠
- p.Gln160Arg Single submitter ⚠
- p.Gln250Pro Single submitter ⚠
- p.Gln84Pro Single submitter ⚠
- p.Gly101Ser Single submitter ⚠
- p.Gly185Arg Single submitter ⚠
- p.Gly186Ala Single submitter ⚠
- p.Gly192Ala Single submitter ⚠
- p.Gly255Val Single submitter ⚠
- p.Gly30Glu Single submitter ⚠
- p.Ile54Val Single submitter ⚠
- p.Ile79Thr Single submitter ⚠
- p.Leu126Pro Single submitter ⚠
- p.Leu230Val Single submitter ⚠
- p.Leu306Arg Single submitter ⚠
- p.Lys127Glu Single submitter ⚠
- p.Lys314Asn Single submitter ⚠
- p.Met8Val Single submitter ⚠
- p.Met92Ile Single submitter ⚠
- p.Phe312Leu Single submitter ⚠
- p.Phe316Ser Single submitter ⚠
- p.Pro146Ala Single submitter ⚠
- p.Pro272Leu Single submitter ⚠
- p.Ser191Tyr Single submitter ⚠
- p.Ser307Asn Single submitter ⚠
- p.Thr4Ala Single submitter ⚠
- p.Val135Met Single submitter ⚠
- p.Val267Ala Single submitter ⚠
- p.Val59Met Single submitter ⚠