AP1M2 — 68 ClinVar variants
All ClinVar germline AP1M2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
2 Likely benign · 66 Uncertain significance
Full AP1M2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AP1M2 p.Ala156Gly Uncertain significance Single submitter
- AP1M2 p.Arg19Cys Uncertain significance Single submitter
- AP1M2 p.Arg211Trp Uncertain significance Single submitter
- AP1M2 p.Arg243Gln Uncertain significance Single submitter
- AP1M2 p.Arg251Cys Uncertain significance Single submitter
- AP1M2 p.Arg268Cys Uncertain significance Single submitter
- AP1M2 p.Asn180Lys Uncertain significance Single submitter
- AP1M2 p.Glu112Lys Uncertain significance Single submitter
- AP1M2 p.Glu116Lys Uncertain significance Single submitter
- AP1M2 p.Glu284Lys Uncertain significance Single submitter
- AP1M2 p.Gly163Asp Uncertain significance Single submitter
- AP1M2 p.Gly196Ser Uncertain significance Single submitter
- AP1M2 p.Gly350Arg Uncertain significance Single submitter
- AP1M2 p.Gly53Ser Uncertain significance Single submitter
- AP1M2 p.Ile256Met Uncertain significance Single submitter
- AP1M2 p.Leu212Pro Uncertain significance Single submitter
- AP1M2 p.Met395Leu Uncertain significance Single submitter
- AP1M2 p.Phe348Ser Uncertain significance Single submitter
- AP1M2 p.Phe57Cys Uncertain significance Single submitter
- AP1M2 p.Pro123Leu Uncertain significance Single submitter
- AP1M2 p.Pro151Thr Uncertain significance Single submitter
- AP1M2 p.Pro257Leu Uncertain significance Single submitter
- AP1M2 p.Pro323Ser Uncertain significance Single submitter
- AP1M2 p.Pro375Arg Uncertain significance Single submitter
- AP1M2 p.Pro407Ser Uncertain significance Single submitter
- AP1M2 p.Ser158Tyr Uncertain significance Single submitter
- AP1M2 p.Ser205Leu Uncertain significance Single submitter
- AP1M2 p.Ser254Pro Uncertain significance Single submitter
- AP1M2 p.Ser2Ala Uncertain significance Single submitter
- AP1M2 p.Ser331Thr Uncertain significance Single submitter
- AP1M2 p.Ser51Thr Uncertain significance Single submitter
- AP1M2 p.Tyr134Asp Uncertain significance Single submitter
- AP1M2 p.Val11Ile Uncertain significance Single submitter
- AP1M2 p.Val195Ile Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- AP1M2 p.Ala156Thr Uncertain significance Single submitter
- AP1M2 p.Ala3Val Uncertain significance Single submitter
- AP1M2 p.Ala405Thr Uncertain significance Single submitter
- AP1M2 p.Arg104Gln Uncertain significance Single submitter
- AP1M2 p.Arg148Gln Uncertain significance Single submitter
- AP1M2 p.Arg148Trp Uncertain significance Single submitter
- AP1M2 p.Arg217Cys Uncertain significance Single submitter
- AP1M2 p.Arg217His Uncertain significance Single submitter
- AP1M2 p.Arg338Ile Uncertain significance Single submitter
- AP1M2 p.Asn215Ser Uncertain significance Single submitter
- AP1M2 p.Asn308His Uncertain significance Single submitter
- AP1M2 p.Asp24Asn Uncertain significance Single submitter
- AP1M2 p.Asp321Gly Uncertain significance Single submitter
- AP1M2 p.Gln419Arg Uncertain significance Single submitter
- AP1M2 p.Glu42Lys Uncertain significance Single submitter
- AP1M2 p.Gly187Ser Uncertain significance Single submitter
- AP1M2 p.Gly351Asp Uncertain significance Single submitter
- AP1M2 p.His52Gln Uncertain significance Single submitter
- AP1M2 p.Ile130Val Uncertain significance Single submitter
- AP1M2 p.Ile198Val Uncertain significance Single submitter
- AP1M2 p.Leu181Met Uncertain significance Single submitter
- AP1M2 p.Met118Ile Uncertain significance Single submitter
- AP1M2 p.Pro150Leu Uncertain significance Single submitter
- AP1M2 p.Pro374His Uncertain significance Single submitter
- AP1M2 p.Ser128Gly Uncertain significance Single submitter
- AP1M2 p.Thr197Ile Uncertain significance Single submitter
- AP1M2 p.Val149Glu Uncertain significance Single submitter
- AP1M2 p.Val149Met Uncertain significance Single submitter
- AP1M2 p.Val218Gly Uncertain significance Single submitter
- AP1M2 p.Val218Leu Uncertain significance Single submitter
- AP1M2 p.Val218Met Uncertain significance Single submitter
- AP1M2 p.Val25Met Uncertain significance Single submitter
All AP1M2 variants
Likely benign 2
- p.Gly309Ser Single submitter
- p.Ile109= Single submitter
Uncertain significance 66
- p.Ala156Gly Single submitter ⚠
- p.Ala156Thr Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala405Thr Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg148Gln Single submitter ⚠
- p.Arg148Trp Single submitter ⚠
- p.Arg19Cys Single submitter ⚠
- p.Arg211Trp Single submitter ⚠
- p.Arg217Cys Single submitter ⚠
- p.Arg217His Single submitter ⚠
- p.Arg243Gln Single submitter ⚠
- p.Arg251Cys Single submitter ⚠
- p.Arg268Cys Single submitter ⚠
- p.Arg338Ile Single submitter ⚠
- p.Asn180Lys Single submitter ⚠
- p.Asn215Ser Single submitter ⚠
- p.Asn308His Single submitter ⚠
- p.Asp24Asn Single submitter ⚠
- p.Asp321Gly Single submitter ⚠
- p.Gln419Arg Single submitter ⚠
- p.Glu112Lys Single submitter ⚠
- p.Glu116Lys Single submitter ⚠
- p.Glu284Lys Single submitter ⚠
- p.Glu42Lys Single submitter ⚠
- p.Gly163Asp Single submitter ⚠
- p.Gly187Ser Single submitter ⚠
- p.Gly196Ser Single submitter ⚠
- p.Gly350Arg Single submitter ⚠
- p.Gly351Asp Single submitter ⚠
- p.Gly53Ser Single submitter ⚠
- p.His52Gln Single submitter ⚠
- p.Ile130Val Single submitter ⚠
- p.Ile198Val Single submitter ⚠
- p.Ile256Met Single submitter ⚠
- p.Leu181Met Single submitter ⚠
- p.Leu212Pro Single submitter ⚠
- p.Met118Ile Single submitter ⚠
- p.Met395Leu Single submitter ⚠
- p.Phe348Ser Single submitter ⚠
- p.Phe57Cys Single submitter ⚠
- p.Pro123Leu Single submitter ⚠
- p.Pro150Leu Single submitter ⚠
- p.Pro151Thr Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Pro323Ser Single submitter ⚠
- p.Pro374His Single submitter ⚠
- p.Pro375Arg Single submitter ⚠
- p.Pro407Ser Single submitter ⚠
- p.Ser128Gly Single submitter ⚠
- p.Ser158Tyr Single submitter ⚠
- p.Ser205Leu Single submitter ⚠
- p.Ser254Pro Single submitter ⚠
- p.Ser2Ala Single submitter ⚠
- p.Ser331Thr Single submitter ⚠
- p.Ser51Thr Single submitter ⚠
- p.Thr197Ile Single submitter ⚠
- p.Tyr134Asp Single submitter ⚠
- p.Val11Ile Single submitter ⚠
- p.Val149Glu Single submitter ⚠
- p.Val149Met Single submitter ⚠
- p.Val195Ile Single submitter ⚠
- p.Val218Gly Single submitter ⚠
- p.Val218Leu Single submitter ⚠
- p.Val218Met Single submitter ⚠
- p.Val25Met Single submitter ⚠