APCDD1L — 100 ClinVar variants
All ClinVar germline APCDD1L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 96 flagged for review →
4 Likely benign · 96 Uncertain significance
Full APCDD1L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 96
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APCDD1L p.Ala246Ser Uncertain significance Single submitter
- APCDD1L p.Ala3Ser Uncertain significance Single submitter
- APCDD1L p.Arg139His Uncertain significance Single submitter
- APCDD1L p.Arg139Pro Uncertain significance Single submitter
- APCDD1L p.Arg180Trp Uncertain significance Single submitter
- APCDD1L p.Arg231Thr Uncertain significance Single submitter
- APCDD1L p.Arg261His Uncertain significance Single submitter
- APCDD1L p.Arg344Ser Uncertain significance Single submitter
- APCDD1L p.Arg431Lys Uncertain significance Single submitter
- APCDD1L p.Arg54His Uncertain significance Single submitter
- APCDD1L p.Arg67Leu Uncertain significance Single submitter
- APCDD1L p.Arg67Ser Uncertain significance Single submitter
- APCDD1L p.Arg75Pro Uncertain significance Single submitter
- APCDD1L p.Asp461Asn Uncertain significance Single submitter
- APCDD1L p.Cys379Tyr Uncertain significance Single submitter
- APCDD1L p.Cys37Arg Uncertain significance Single submitter
- APCDD1L p.Gln89Pro Uncertain significance Single submitter
- APCDD1L p.Glu412Lys Uncertain significance Single submitter
- APCDD1L p.Gly108Ser Uncertain significance Single submitter
- APCDD1L p.Gly108Val Uncertain significance Single submitter
- APCDD1L p.Gly27Arg Uncertain significance Single submitter
- APCDD1L p.Gly334Ser Uncertain significance Single submitter
- APCDD1L p.Gly429Arg Uncertain significance Single submitter
- APCDD1L p.His249Tyr Uncertain significance Single submitter
- APCDD1L p.Ile60Val Uncertain significance Single submitter
- APCDD1L p.Leu296Pro Uncertain significance Single submitter
- APCDD1L p.Leu298Phe Uncertain significance Single submitter
- APCDD1L p.Leu31Pro Uncertain significance Single submitter
- APCDD1L p.Met370Arg Uncertain significance Single submitter
- APCDD1L p.Met416Thr Uncertain significance Single submitter
- APCDD1L p.Pro40Ser Uncertain significance Single submitter
- APCDD1L p.Pro42Gln Uncertain significance Single submitter
- APCDD1L p.Ser103Leu Uncertain significance Single submitter
- APCDD1L p.Ser103Pro Uncertain significance Single submitter
- APCDD1L p.Ser287Leu Uncertain significance Single submitter
- APCDD1L p.Ser377Asn Uncertain significance Single submitter
- APCDD1L p.Ser424Asn Uncertain significance Single submitter
- APCDD1L p.Trp283Cys Uncertain significance Single submitter
- APCDD1L p.Tyr92His Uncertain significance Single submitter
- APCDD1L p.Val118Ile Uncertain significance Single submitter
- APCDD1L p.Val132Met Uncertain significance Single submitter
- APCDD1L p.Val13Leu Uncertain significance Single submitter
- APCDD1L p.Val250Leu Uncertain significance Single submitter
- APCDD1L p.Val291Ala Uncertain significance Single submitter
Predictors split 52
The independent predictors disagree with each other — read with care.
- APCDD1L p.Ala141Val Uncertain significance Single submitter
- APCDD1L p.Ala159Glu Uncertain significance Single submitter
- APCDD1L p.Ala333Thr Uncertain significance Single submitter
- APCDD1L p.Arg153Cys Uncertain significance Single submitter
- APCDD1L p.Arg166Trp Uncertain significance Single submitter
- APCDD1L p.Arg235Pro Uncertain significance Single submitter
- APCDD1L p.Arg292Cys Uncertain significance Single submitter
- APCDD1L p.Arg309Cys Uncertain significance Single submitter
- APCDD1L p.Arg324Trp Uncertain significance Single submitter
- APCDD1L p.Arg54Cys Uncertain significance Single submitter
- APCDD1L p.Arg75Cys Uncertain significance Single submitter
- APCDD1L p.Arg83Trp Uncertain significance Single submitter
- APCDD1L p.Arg86Gly Uncertain significance Single submitter
- APCDD1L p.Asp184Tyr Uncertain significance Single submitter
- APCDD1L p.Asp263Tyr Uncertain significance Single submitter
- APCDD1L p.Asp43Tyr Uncertain significance Single submitter
- APCDD1L p.Cys158Ser Uncertain significance Single submitter
- APCDD1L p.Cys185Gly Uncertain significance Single submitter
- APCDD1L p.Gln89His Uncertain significance Single submitter
- APCDD1L p.Gly347Ser Uncertain significance Single submitter
- APCDD1L p.Gly381Arg Uncertain significance Single submitter
- APCDD1L p.Gly383Arg Uncertain significance Single submitter
- APCDD1L p.His316Arg Uncertain significance Single submitter
- APCDD1L p.Ile428Asn Uncertain significance Single submitter
- APCDD1L p.Ile428Thr Uncertain significance Single submitter
- APCDD1L p.Leu104Met Uncertain significance Single submitter
- APCDD1L p.Leu402Val Uncertain significance Single submitter
- APCDD1L p.Leu421Pro Uncertain significance Single submitter
- APCDD1L p.Leu481Phe Uncertain significance Single submitter
- APCDD1L p.Leu498Phe Uncertain significance Single submitter
- APCDD1L p.Leu55Pro Uncertain significance Single submitter
- APCDD1L p.Leu55Val Uncertain significance Single submitter
- APCDD1L p.Met193Ile Uncertain significance Single submitter
- APCDD1L p.Pro164Leu Uncertain significance Single submitter
- APCDD1L p.Pro209Ser Uncertain significance Single submitter
- APCDD1L p.Pro252Arg Uncertain significance Single submitter
- APCDD1L p.Pro273Leu Uncertain significance Single submitter
- APCDD1L p.Pro401Leu Uncertain significance Single submitter
- APCDD1L p.Pro451Thr Uncertain significance Single submitter
- APCDD1L p.Ser374Phe Uncertain significance Single submitter
- APCDD1L p.Ser82Cys Uncertain significance Single submitter
- APCDD1L p.Thr146Ile Uncertain significance Single submitter
- APCDD1L p.Thr299Ile Uncertain significance Single submitter
- APCDD1L p.Thr299Pro Uncertain significance Single submitter
- APCDD1L p.Thr340Met Uncertain significance Single submitter
- APCDD1L p.Thr361Ile Uncertain significance Single submitter
- APCDD1L p.Thr440Ile Uncertain significance Single submitter
- APCDD1L p.Thr62Ile Uncertain significance Single submitter
- APCDD1L p.Val145Gly Uncertain significance Single submitter
- APCDD1L p.Val250Met Uncertain significance Single submitter
- APCDD1L p.Val269Met Uncertain significance Single submitter
- APCDD1L p.Val291Met Uncertain significance Single submitter
All APCDD1L variants
Likely benign 4
- p.Ala22= Single submitter
- p.Arg241His Single submitter
- p.Arg32His Single submitter
- p.Asn56Ser Single submitter
Uncertain significance 96
- p.Ala141Val Single submitter ⚠
- p.Ala159Glu Single submitter ⚠
- p.Ala246Ser Single submitter ⚠
- p.Ala333Thr Single submitter ⚠
- p.Ala3Ser Single submitter ⚠
- p.Arg139His Single submitter ⚠
- p.Arg139Pro Single submitter ⚠
- p.Arg153Cys Single submitter ⚠
- p.Arg166Trp Single submitter ⚠
- p.Arg180Trp Single submitter ⚠
- p.Arg231Thr Single submitter ⚠
- p.Arg235Pro Single submitter ⚠
- p.Arg261His Single submitter ⚠
- p.Arg292Cys Single submitter ⚠
- p.Arg309Cys Single submitter ⚠
- p.Arg324Trp Single submitter ⚠
- p.Arg344Ser Single submitter ⚠
- p.Arg431Lys Single submitter ⚠
- p.Arg54Cys Single submitter ⚠
- p.Arg54His Single submitter ⚠
- p.Arg67Leu Single submitter ⚠
- p.Arg67Ser Single submitter ⚠
- p.Arg75Cys Single submitter ⚠
- p.Arg75Pro Single submitter ⚠
- p.Arg83Trp Single submitter ⚠
- p.Arg86Gly Single submitter ⚠
- p.Asp184Tyr Single submitter ⚠
- p.Asp263Tyr Single submitter ⚠
- p.Asp43Tyr Single submitter ⚠
- p.Asp461Asn Single submitter ⚠
- p.Cys158Ser Single submitter ⚠
- p.Cys185Gly Single submitter ⚠
- p.Cys379Tyr Single submitter ⚠
- p.Cys37Arg Single submitter ⚠
- p.Gln89His Single submitter ⚠
- p.Gln89Pro Single submitter ⚠
- p.Glu412Lys Single submitter ⚠
- p.Gly108Ser Single submitter ⚠
- p.Gly108Val Single submitter ⚠
- p.Gly27Arg Single submitter ⚠
- p.Gly334Ser Single submitter ⚠
- p.Gly347Ser Single submitter ⚠
- p.Gly381Arg Single submitter ⚠
- p.Gly383Arg Single submitter ⚠
- p.Gly429Arg Single submitter ⚠
- p.His249Tyr Single submitter ⚠
- p.His316Arg Single submitter ⚠
- p.Ile428Asn Single submitter ⚠
- p.Ile428Thr Single submitter ⚠
- p.Ile60Val Single submitter ⚠
- p.Leu104Met Single submitter ⚠
- p.Leu296Pro Single submitter ⚠
- p.Leu298Phe Single submitter ⚠
- p.Leu31Pro Single submitter ⚠
- p.Leu402Val Single submitter ⚠
- p.Leu421Pro Single submitter ⚠
- p.Leu481Phe Single submitter ⚠
- p.Leu498Phe Single submitter ⚠
- p.Leu55Pro Single submitter ⚠
- p.Leu55Val Single submitter ⚠
- p.Met193Ile Single submitter ⚠
- p.Met370Arg Single submitter ⚠
- p.Met416Thr Single submitter ⚠
- p.Pro164Leu Single submitter ⚠
- p.Pro209Ser Single submitter ⚠
- p.Pro252Arg Single submitter ⚠
- p.Pro273Leu Single submitter ⚠
- p.Pro401Leu Single submitter ⚠
- p.Pro40Ser Single submitter ⚠
- p.Pro42Gln Single submitter ⚠
- p.Pro451Thr Single submitter ⚠
- p.Ser103Leu Single submitter ⚠
- p.Ser103Pro Single submitter ⚠
- p.Ser287Leu Single submitter ⚠
- p.Ser374Phe Single submitter ⚠
- p.Ser377Asn Single submitter ⚠
- p.Ser424Asn Single submitter ⚠
- p.Ser82Cys Single submitter ⚠
- p.Thr146Ile Single submitter ⚠
- p.Thr299Ile Single submitter ⚠
- p.Thr299Pro Single submitter ⚠
- p.Thr340Met Single submitter ⚠
- p.Thr361Ile Single submitter ⚠
- p.Thr440Ile Single submitter ⚠
- p.Thr62Ile Single submitter ⚠
- p.Trp283Cys Single submitter ⚠
- p.Tyr92His Single submitter ⚠
- p.Val118Ile Single submitter ⚠
- p.Val132Met Single submitter ⚠
- p.Val13Leu Single submitter ⚠
- p.Val145Gly Single submitter ⚠
- p.Val250Leu Single submitter ⚠
- p.Val250Met Single submitter ⚠
- p.Val269Met Single submitter ⚠
- p.Val291Ala Single submitter ⚠
- p.Val291Met Single submitter ⚠