APIP — 29 ClinVar variants
All ClinVar germline APIP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Benign · 3 Likely benign · 25 Uncertain significance
Full APIP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APIP p.Ala6Val Uncertain significance Single submitter
- APIP p.Arg194His Uncertain significance Single submitter
- APIP p.Arg194Ser Uncertain significance Single submitter
- APIP p.Arg67Gln Uncertain significance Single submitter
- APIP p.Cys213Phe Uncertain significance Single submitter
- APIP p.Glu66Ala Uncertain significance Single submitter
- APIP p.Gly47Arg Uncertain significance Single submitter
- APIP p.Gly9Ala Uncertain significance Single submitter
- APIP p.Ile241Thr Uncertain significance Single submitter
- APIP p.Leu191Pro Uncertain significance Single submitter
- APIP p.Met158Ile Uncertain significance Single submitter
- APIP p.Met158Leu Uncertain significance Single submitter
- APIP p.Met158Thr Uncertain significance Single submitter
- APIP p.Thr116Ala Uncertain significance Single submitter
- APIP p.Tyr198His Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- APIP p.Arg131Trp Uncertain significance Single submitter
- APIP p.Arg14Trp Uncertain significance Single submitter
- APIP p.Asn103Ser Uncertain significance Single submitter
- APIP p.Asn239Ser Uncertain significance Single submitter
- APIP p.Cys188Tyr Uncertain significance Single submitter
- APIP p.Glu71Lys Uncertain significance Single submitter
- APIP p.Leu126Val Uncertain significance Single submitter
- APIP p.Met107Val Uncertain significance Single submitter
- APIP p.Phe35Leu Uncertain significance Single submitter
- APIP p.Pro70Leu Uncertain significance Single submitter
- APIP p.Val222Ile Likely benign Single submitter
All APIP variants
Benign 1
- c.461+11_461+12del Single submitter
Likely benign 3
- c.461+6_461+7insG Single submitter
- p.Asp54Asn Single submitter
- p.Val222Ile Single submitter ⚠
Uncertain significance 25
- p.Ala6Val Single submitter ⚠
- p.Arg131Trp Single submitter ⚠
- p.Arg14Trp Single submitter ⚠
- p.Arg194His Single submitter ⚠
- p.Arg194Ser Single submitter ⚠
- p.Arg67Gln Single submitter ⚠
- p.Asn103Ser Single submitter ⚠
- p.Asn239Ser Single submitter ⚠
- p.Cys188Tyr Single submitter ⚠
- p.Cys213Phe Single submitter ⚠
- p.Glu66Ala Single submitter ⚠
- p.Glu71Lys Single submitter ⚠
- p.Gly47Arg Single submitter ⚠
- p.Gly9Ala Single submitter ⚠
- p.Ile241Thr Single submitter ⚠
- p.Leu126Val Single submitter ⚠
- p.Leu191Pro Single submitter ⚠
- p.Met107Val Single submitter ⚠
- p.Met158Ile Single submitter ⚠
- p.Met158Leu Single submitter ⚠
- p.Met158Thr Single submitter ⚠
- p.Phe35Leu Single submitter ⚠
- p.Pro70Leu Single submitter ⚠
- p.Thr116Ala Single submitter ⚠
- p.Tyr198His Single submitter ⚠