APLNR — 66 ClinVar variants
All ClinVar germline APLNR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
1 Benign · 3 Likely benign · 62 Uncertain significance
Full APLNR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APLNR p.Ala158Thr Uncertain significance Single submitter
- APLNR p.Ala258Ser Uncertain significance Single submitter
- APLNR p.Ala33Thr Uncertain significance Single submitter
- APLNR p.Ala64Thr Uncertain significance Single submitter
- APLNR p.Arg127Cys Uncertain significance Single submitter
- APLNR p.Arg143Gln Uncertain significance Single submitter
- APLNR p.Arg233Cys Uncertain significance Single submitter
- APLNR p.Arg233His Uncertain significance Single submitter
- APLNR p.Arg233Leu Uncertain significance Single submitter
- APLNR p.Arg241Trp Uncertain significance Single submitter
- APLNR p.Arg244His Uncertain significance Single submitter
- APLNR p.Arg245Gln Uncertain significance Single submitter
- APLNR p.Arg330Met Uncertain significance Single submitter
- APLNR p.Arg330Thr Uncertain significance Single submitter
- APLNR p.Arg55Gln Uncertain significance Single submitter
- APLNR p.Arg58Trp Uncertain significance Single submitter
- APLNR p.Arg91Trp Uncertain significance Single submitter
- APLNR p.Asn137Asp Uncertain significance Single submitter
- APLNR p.Gln180His Uncertain significance Single submitter
- APLNR p.Glu235Lys Uncertain significance Single submitter
- APLNR p.Gly122Ser Uncertain significance Single submitter
- APLNR p.Gly171Arg Uncertain significance Single submitter
- APLNR p.Ile228Val Uncertain significance Single submitter
- APLNR p.Leu120Ile Uncertain significance Single submitter
- APLNR p.Leu266Val Uncertain significance Single submitter
- APLNR p.Leu277Val Uncertain significance Single submitter
- APLNR p.Leu308Val Uncertain significance Single submitter
- APLNR p.Lys360Arg Uncertain significance Single submitter
- APLNR p.Met183Arg Uncertain significance Single submitter
- APLNR p.Pro314Ala Uncertain significance Single submitter
- APLNR p.Pro314Thr Uncertain significance Single submitter
- APLNR p.Ser204Leu Uncertain significance Single submitter
- APLNR p.Ser248Thr Uncertain significance Single submitter
- APLNR p.Ser338Gly Uncertain significance Single submitter
- APLNR p.Ser348Pro Uncertain significance Single submitter
- APLNR p.Thr150Met Uncertain significance Single submitter
- APLNR p.Val111Ile Uncertain significance Single submitter
- APLNR p.Val117Ile Uncertain significance Single submitter
- APLNR p.Val148Met Uncertain significance Single submitter
- APLNR p.Val166Ala Uncertain significance Single submitter
- APLNR p.Val208Leu Uncertain significance Single submitter
- APLNR p.Val211Leu Uncertain significance Single submitter
- APLNR p.Val251Met Uncertain significance Single submitter
- APLNR p.Val379Ala Uncertain significance Single submitter
- APLNR p.Val80Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- APLNR p.Ala151Glu Uncertain significance Single submitter
- APLNR p.Arg55Trp Uncertain significance Single submitter
- APLNR p.Phe223Leu Uncertain significance Single submitter
- APLNR p.Ser205Tyr Uncertain significance Single submitter
- APLNR p.Thr177Ile Uncertain significance Single submitter
- APLNR p.Thr295Asn Uncertain significance Single submitter
- APLNR p.Thr295Ile Uncertain significance Single submitter
- APLNR p.Thr81Met Uncertain significance Single submitter
- APLNR p.Thr89Lys Uncertain significance Single submitter
- APLNR p.Tyr10Cys Uncertain significance Single submitter
- APLNR p.Tyr264His Uncertain significance Single submitter
- APLNR p.Val111Ala Uncertain significance Single submitter
- APLNR p.Val79Met Uncertain significance Single submitter
All APLNR variants
Benign 1
- p.Val300Ile Multiple submitters
Likely benign 3
- p.Leu324= Single submitter
- p.Ser27= Single submitter
- p.Val53Met Single submitter
Uncertain significance 62
- p.Ala115Thr Single submitter
- p.Ala151Glu Single submitter ⚠
- p.Ala158Thr Single submitter ⚠
- p.Ala258Ser Single submitter ⚠
- p.Ala33Thr Single submitter ⚠
- p.Ala64Thr Single submitter ⚠
- p.Arg127Cys Single submitter ⚠
- p.Arg143Gln Single submitter ⚠
- p.Arg233Cys Single submitter ⚠
- p.Arg233His Single submitter ⚠
- p.Arg233Leu Single submitter ⚠
- p.Arg241Trp Single submitter ⚠
- p.Arg244Cys Single submitter
- p.Arg244His Single submitter ⚠
- p.Arg245Gln Single submitter ⚠
- p.Arg330Met Single submitter ⚠
- p.Arg330Thr Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Arg55Trp Single submitter ⚠
- p.Arg58Trp Single submitter ⚠
- p.Arg91Trp Single submitter ⚠
- p.Asn137Asp Single submitter ⚠
- p.Gln180His Single submitter ⚠
- p.Glu235Lys Single submitter ⚠
- p.Gly122Ser Single submitter ⚠
- p.Gly171Arg Single submitter ⚠
- p.Ile228Val Single submitter ⚠
- p.Leu120Ile Single submitter ⚠
- p.Leu160Val Single submitter
- p.Leu266Val Single submitter ⚠
- p.Leu277Val Single submitter ⚠
- p.Leu308Val Single submitter ⚠
- p.Lys360Arg Single submitter ⚠
- p.Met183Arg Single submitter ⚠
- p.Phe223Leu Single submitter ⚠
- p.Pro314Ala Single submitter ⚠
- p.Pro314Thr Single submitter ⚠
- p.Ser204Leu Single submitter ⚠
- p.Ser205Tyr Single submitter ⚠
- p.Ser248Thr Single submitter ⚠
- p.Ser338Gly Single submitter ⚠
- p.Ser348Pro Single submitter ⚠
- p.Thr150Met Single submitter ⚠
- p.Thr177Ile Single submitter ⚠
- p.Thr295Asn Single submitter ⚠
- p.Thr295Ile Single submitter ⚠
- p.Thr81Met Single submitter ⚠
- p.Thr89Lys Single submitter ⚠
- p.Tyr10Cys Single submitter ⚠
- p.Tyr264His Single submitter ⚠
- p.Tyr271Asp Single submitter
- p.Val111Ala Single submitter ⚠
- p.Val111Ile Single submitter ⚠
- p.Val117Ile Single submitter ⚠
- p.Val148Met Single submitter ⚠
- p.Val166Ala Single submitter ⚠
- p.Val208Leu Single submitter ⚠
- p.Val211Leu Single submitter ⚠
- p.Val251Met Single submitter ⚠
- p.Val379Ala Single submitter ⚠
- p.Val79Met Single submitter ⚠
- p.Val80Met Single submitter ⚠