APLP1 — 88 ClinVar variants
All ClinVar germline APLP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →
1 Benign · 5 Likely benign · 82 Uncertain significance
Full APLP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 83
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APLP1 p.Ala149Asp Uncertain significance Single submitter
- APLP1 p.Ala222Pro Uncertain significance Single submitter
- APLP1 p.Ala263Thr Uncertain significance Single submitter
- APLP1 p.Ala382Thr Uncertain significance Single submitter
- APLP1 p.Ala47Glu Uncertain significance Single submitter
- APLP1 p.Arg163Pro Uncertain significance Single submitter
- APLP1 p.Arg229Gln Uncertain significance Single submitter
- APLP1 p.Arg229Trp Uncertain significance Single submitter
- APLP1 p.Arg369Gln Uncertain significance Single submitter
- APLP1 p.Arg478Gln Uncertain significance Single submitter
- APLP1 p.Arg478Leu Uncertain significance Single submitter
- APLP1 p.Arg580Gly Uncertain significance Single submitter
- APLP1 p.Arg90Leu Uncertain significance Single submitter
- APLP1 p.Arg9Gly Uncertain significance Single submitter
- APLP1 p.Asp506Val Uncertain significance Single submitter
- APLP1 p.Asp68Asn Uncertain significance Single submitter
- APLP1 p.Gln400Lys Uncertain significance Single submitter
- APLP1 p.Gln531His Uncertain significance Single submitter
- APLP1 p.Gln546Arg Uncertain significance Single submitter
- APLP1 p.Glu303Gly Uncertain significance Single submitter
- APLP1 p.Glu505Lys Uncertain significance Single submitter
- APLP1 p.Glu537Ala Uncertain significance Single submitter
- APLP1 p.Glu633Gln Uncertain significance Single submitter
- APLP1 p.Gly594Val Uncertain significance Single submitter
- APLP1 p.Gly616Asp Uncertain significance Single submitter
- APLP1 p.Ile566Met Uncertain significance Single submitter
- APLP1 p.Ile613Thr Uncertain significance Single submitter
- APLP1 p.Leu410Pro Uncertain significance Single submitter
- APLP1 p.Lys607Arg Uncertain significance Single submitter
- APLP1 p.Met334Thr Uncertain significance Single submitter
- APLP1 p.Phe447Ser Uncertain significance Single submitter
- APLP1 p.Pro131Thr Uncertain significance Single submitter
- APLP1 p.Pro232Ser Uncertain significance Single submitter
- APLP1 p.Pro233Arg Uncertain significance Single submitter
- APLP1 p.Pro492Ser Uncertain significance Single submitter
- APLP1 p.Pro573Gln Uncertain significance Single submitter
- APLP1 p.Pro573Leu Uncertain significance Single submitter
- APLP1 p.Ser147Asn Uncertain significance Single submitter
- APLP1 p.Ser274Gly Uncertain significance Single submitter
- APLP1 p.Ser515Thr Uncertain significance Single submitter
- APLP1 p.Ser53Leu Uncertain significance Single submitter
- APLP1 p.Ser564Leu Uncertain significance Single submitter
- APLP1 p.Thr111Arg Uncertain significance Single submitter
- APLP1 p.Thr529Ala Uncertain significance Single submitter
- APLP1 p.Val208Ala Uncertain significance Single submitter
- APLP1 p.Val253Leu Uncertain significance Single submitter
- APLP1 p.Val598Ile Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- APLP1 p.Ala391Val Uncertain significance Single submitter
- APLP1 p.Ala412Thr Uncertain significance Single submitter
- APLP1 p.Ala57Val Uncertain significance Single submitter
- APLP1 p.Arg124Trp Uncertain significance Single submitter
- APLP1 p.Arg139His Likely benign Single submitter
- APLP1 p.Arg14His Uncertain significance Single submitter
- APLP1 p.Arg173Lys Uncertain significance Single submitter
- APLP1 p.Arg320His Uncertain significance Single submitter
- APLP1 p.Arg320Ser Uncertain significance Single submitter
- APLP1 p.Arg330Ser Uncertain significance Single submitter
- APLP1 p.Arg379His Uncertain significance Single submitter
- APLP1 p.Arg414Trp Uncertain significance Single submitter
- APLP1 p.Arg418His Uncertain significance Single submitter
- APLP1 p.Arg429Cys Uncertain significance Single submitter
- APLP1 p.Arg429His Uncertain significance Single submitter
- APLP1 p.Arg478Trp Uncertain significance Single submitter
- APLP1 p.Arg82Gln Uncertain significance Single submitter
- APLP1 p.Asp346Asn Uncertain significance Single submitter
- APLP1 p.Asp386His Uncertain significance Single submitter
- APLP1 p.Asp621Asn Uncertain significance Single submitter
- APLP1 p.Gln161Glu Uncertain significance Single submitter
- APLP1 p.Glu241Lys Uncertain significance Single submitter
- APLP1 p.Gly72Ala Uncertain significance Single submitter
- APLP1 p.Phe257Leu Uncertain significance Single submitter
- APLP1 p.Pro403Leu Uncertain significance Single submitter
- APLP1 p.Ser123Tyr Uncertain significance Single submitter
- APLP1 p.Ser125Asn Uncertain significance Single submitter
- APLP1 p.Ser339Tyr Uncertain significance Single submitter
- APLP1 p.Ser366Cys Uncertain significance Single submitter
- APLP1 p.Ser614Thr Uncertain significance Single submitter
- APLP1 p.Thr215Asn Uncertain significance Single submitter
- APLP1 p.Thr64Ala Uncertain significance Single submitter
- APLP1 p.Val237Ile Uncertain significance Single submitter
- APLP1 p.Val270Ile Uncertain significance Single submitter
- APLP1 p.Val365Met Uncertain significance Single submitter
- APLP1 p.Val598Phe Uncertain significance Single submitter
All APLP1 variants
Benign 1
- p.Asp316= Single submitter
Likely benign 5
- p.Ala129Thr Single submitter
- p.Ala612Thr Single submitter
- p.Arg139His Single submitter ⚠
- p.Gly282Ser Single submitter
- p.Pro233Leu Single submitter
Uncertain significance 82
- p.Ala149Asp Single submitter ⚠
- p.Ala222Pro Single submitter ⚠
- p.Ala263Thr Single submitter ⚠
- p.Ala382Thr Single submitter ⚠
- p.Ala391Val Single submitter ⚠
- p.Ala412Thr Single submitter ⚠
- p.Ala47Glu Single submitter ⚠
- p.Ala57Val Single submitter ⚠
- p.Arg124Trp Single submitter ⚠
- p.Arg14His Single submitter ⚠
- p.Arg163Pro Single submitter ⚠
- p.Arg173Lys Single submitter ⚠
- p.Arg229Gln Single submitter ⚠
- p.Arg229Trp Single submitter ⚠
- p.Arg320His Single submitter ⚠
- p.Arg320Ser Single submitter ⚠
- p.Arg330Ser Single submitter ⚠
- p.Arg369Gln Single submitter ⚠
- p.Arg379His Single submitter ⚠
- p.Arg414Trp Single submitter ⚠
- p.Arg418His Single submitter ⚠
- p.Arg429Cys Single submitter ⚠
- p.Arg429His Single submitter ⚠
- p.Arg478Gln Single submitter ⚠
- p.Arg478Leu Single submitter ⚠
- p.Arg478Trp Single submitter ⚠
- p.Arg580Gly Single submitter ⚠
- p.Arg82Gln Single submitter ⚠
- p.Arg90Leu Single submitter ⚠
- p.Arg9Gly Single submitter ⚠
- p.Asp346Asn Single submitter ⚠
- p.Asp386His Single submitter ⚠
- p.Asp506Val Single submitter ⚠
- p.Asp621Asn Single submitter ⚠
- p.Asp68Asn Single submitter ⚠
- p.Gln161Glu Single submitter ⚠
- p.Gln400Lys Single submitter ⚠
- p.Gln531His Single submitter ⚠
- p.Gln546Arg Single submitter ⚠
- p.Glu241Lys Single submitter ⚠
- p.Glu303Gly Single submitter ⚠
- p.Glu505Lys Single submitter ⚠
- p.Glu537Ala Single submitter ⚠
- p.Glu633Gln Single submitter ⚠
- p.Gly594Val Single submitter ⚠
- p.Gly616Asp Single submitter ⚠
- p.Gly72Ala Single submitter ⚠
- p.Ile566Met Single submitter ⚠
- p.Ile613Thr Single submitter ⚠
- p.Leu410Pro Single submitter ⚠
- p.Lys607Arg Single submitter ⚠
- p.Met334Thr Single submitter ⚠
- p.Phe257Leu Single submitter ⚠
- p.Phe447Ser Single submitter ⚠
- p.Pro131Thr Single submitter ⚠
- p.Pro232Ser Single submitter ⚠
- p.Pro233Arg Single submitter ⚠
- p.Pro403Leu Single submitter ⚠
- p.Pro492Ser Single submitter ⚠
- p.Pro573Gln Single submitter ⚠
- p.Pro573Leu Single submitter ⚠
- p.Ser123Tyr Single submitter ⚠
- p.Ser125Asn Single submitter ⚠
- p.Ser147Asn Single submitter ⚠
- p.Ser274Gly Single submitter ⚠
- p.Ser339Tyr Single submitter ⚠
- p.Ser366Cys Single submitter ⚠
- p.Ser515Thr Single submitter ⚠
- p.Ser53Leu Single submitter ⚠
- p.Ser564Leu Single submitter ⚠
- p.Ser614Thr Single submitter ⚠
- p.Thr111Arg Single submitter ⚠
- p.Thr215Asn Single submitter ⚠
- p.Thr529Ala Single submitter ⚠
- p.Thr64Ala Single submitter ⚠
- p.Val208Ala Single submitter ⚠
- p.Val237Ile Single submitter ⚠
- p.Val253Leu Single submitter ⚠
- p.Val270Ile Single submitter ⚠
- p.Val365Met Single submitter ⚠
- p.Val598Ile Single submitter ⚠
- p.Val598Phe Single submitter ⚠