APLP2 — 136 ClinVar variants
All ClinVar germline APLP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 130 flagged for review →
2 Benign · 4 Likely benign · 130 Uncertain significance
Full APLP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 130
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 81
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APLP2 p.Val336Leu Uncertain significance Multiple submitters
- APLP2 c.1837+1543A>G Uncertain significance Single submitter
- APLP2 c.1837+1550C>T Uncertain significance Single submitter
- APLP2 c.1837+1564C>A Uncertain significance Single submitter
- APLP2 c.1837+1564C>T Uncertain significance Single submitter
- APLP2 c.1837+1567A>G Uncertain significance Single submitter
- APLP2 c.1837+1571A>G Uncertain significance Single submitter
- APLP2 p.Ala244Thr Uncertain significance Single submitter
- APLP2 p.Ala252Val Uncertain significance Single submitter
- APLP2 p.Ala362Val Uncertain significance Single submitter
- APLP2 p.Ala36Ser Uncertain significance Single submitter
- APLP2 p.Ala382Val Uncertain significance Single submitter
- APLP2 p.Ala415Thr Uncertain significance Single submitter
- APLP2 p.Arg126Leu Uncertain significance Single submitter
- APLP2 p.Arg156Gln Uncertain significance Single submitter
- APLP2 p.Arg271Gln Uncertain significance Single submitter
- APLP2 p.Arg320Trp Uncertain significance Single submitter
- APLP2 p.Arg325Cys Uncertain significance Single submitter
- APLP2 p.Arg325His Uncertain significance Single submitter
- APLP2 p.Arg404Gln Uncertain significance Single submitter
- APLP2 p.Arg485Gln Uncertain significance Single submitter
- APLP2 p.Arg495Cys Uncertain significance Single submitter
- APLP2 p.Arg498Cys Uncertain significance Single submitter
- APLP2 p.Arg666Gln Uncertain significance Single submitter
- APLP2 p.Asn349Ser Uncertain significance Single submitter
- APLP2 p.Asn372Ser Uncertain significance Single submitter
- APLP2 p.Asn40Ser Uncertain significance Single submitter
- APLP2 p.Asn465Ser Uncertain significance Single submitter
- APLP2 p.Asn541His Uncertain significance Single submitter
- APLP2 p.Asn635Ser Uncertain significance Single submitter
- APLP2 p.Asn655Ser Uncertain significance Single submitter
- APLP2 p.Asp258Glu Uncertain significance Single submitter
- APLP2 p.Cys123Phe Uncertain significance Single submitter
- APLP2 p.Cys360Arg Uncertain significance Single submitter
- APLP2 p.Gln542Lys Uncertain significance Single submitter
- APLP2 p.Glu147Asp Uncertain significance Single submitter
- APLP2 p.Glu224Asp Uncertain significance Single submitter
- APLP2 p.Glu442Gln Uncertain significance Single submitter
- APLP2 p.Glu627Lys Uncertain significance Single submitter
- APLP2 p.Glu645Gln Uncertain significance Single submitter
- APLP2 p.Glu657Lys Uncertain significance Single submitter
- APLP2 p.Glu86Asp Uncertain significance Single submitter
- APLP2 p.Gly210Ala Uncertain significance Single submitter
- APLP2 p.Gly345Cys Uncertain significance Single submitter
- APLP2 p.Gly617Arg Uncertain significance Single submitter
- APLP2 p.His487Asp Uncertain significance Single submitter
- APLP2 p.His736Asn Uncertain significance Single submitter
- APLP2 p.Ile579Val Uncertain significance Single submitter
- APLP2 p.Ile596Asn Uncertain significance Single submitter
- APLP2 p.Ile751Val Uncertain significance Single submitter
- APLP2 p.Leu175Arg Uncertain significance Single submitter
- APLP2 p.Leu608Pro Uncertain significance Single submitter
- APLP2 p.Leu683Val Uncertain significance Single submitter
- APLP2 p.Lys443Glu Uncertain significance Single submitter
- APLP2 p.Met297Val Uncertain significance Single submitter
- APLP2 p.Met363Thr Uncertain significance Single submitter
- APLP2 p.Met530Ile Uncertain significance Single submitter
- APLP2 p.Met94Leu Uncertain significance Single submitter
- APLP2 p.Phe599Leu Uncertain significance Single submitter
- APLP2 p.Phe676Ile Uncertain significance Single submitter
- APLP2 p.Pro288Arg Uncertain significance Single submitter
- APLP2 p.Pro484Leu Uncertain significance Single submitter
- APLP2 p.Pro486Arg Uncertain significance Single submitter
- APLP2 p.Pro50Ser Uncertain significance Single submitter
- APLP2 p.Pro598Ser Uncertain significance Single submitter
- APLP2 p.Ser293Thr Uncertain significance Single submitter
- APLP2 p.Ser447Asn Uncertain significance Single submitter
- APLP2 p.Ser589Gly Uncertain significance Single submitter
- APLP2 p.Thr289Ala Uncertain significance Single submitter
- APLP2 p.Thr380Pro Uncertain significance Single submitter
- APLP2 p.Tyr233Phe Uncertain significance Single submitter
- APLP2 p.Tyr33Ser Uncertain significance Single submitter
- APLP2 p.Tyr340Cys Uncertain significance Single submitter
- APLP2 p.Tyr709His Uncertain significance Single submitter
- APLP2 p.Val145Phe Uncertain significance Single submitter
- APLP2 p.Val159Met Uncertain significance Single submitter
- APLP2 p.Val192Ile Uncertain significance Single submitter
- APLP2 p.Val322Met Uncertain significance Single submitter
- APLP2 p.Val586Ile Uncertain significance Single submitter
- APLP2 p.Val588Met Uncertain significance Single submitter
- APLP2 p.Val642Ile Uncertain significance Single submitter
Predictors split 49
The independent predictors disagree with each other — read with care.
- APLP2 p.Ala445Val Uncertain significance Single submitter
- APLP2 p.Ala53Gly Uncertain significance Single submitter
- APLP2 p.Ala682Thr Uncertain significance Single submitter
- APLP2 p.Arg117Trp Uncertain significance Single submitter
- APLP2 p.Arg126Cys Uncertain significance Single submitter
- APLP2 p.Arg337Cys Uncertain significance Single submitter
- APLP2 p.Arg337His Uncertain significance Single submitter
- APLP2 p.Arg407Gly Uncertain significance Single submitter
- APLP2 p.Arg485Trp Uncertain significance Single submitter
- APLP2 p.Arg488His Uncertain significance Single submitter
- APLP2 p.Arg495His Uncertain significance Single submitter
- APLP2 p.Arg504Cys Uncertain significance Single submitter
- APLP2 p.Arg509Cys Uncertain significance Single submitter
- APLP2 p.Arg569Cys Uncertain significance Single submitter
- APLP2 p.Arg569His Uncertain significance Single submitter
- APLP2 p.Arg673Trp Uncertain significance Single submitter
- APLP2 p.Asn541Ser Uncertain significance Single submitter
- APLP2 p.Asn60His Uncertain significance Single submitter
- APLP2 p.Asp257Tyr Uncertain significance Single submitter
- APLP2 p.Asp329Asn Uncertain significance Single submitter
- APLP2 p.Gln194Glu Uncertain significance Single submitter
- APLP2 p.Glu222Gly Uncertain significance Single submitter
- APLP2 p.Glu351Gln Uncertain significance Single submitter
- APLP2 p.Glu353Val Uncertain significance Single submitter
- APLP2 p.Glu520Gly Uncertain significance Single submitter
- APLP2 p.Glu592Lys Uncertain significance Single submitter
- APLP2 p.Glu86Val Uncertain significance Single submitter
- APLP2 p.Gly136Ser Uncertain significance Single submitter
- APLP2 p.Gly191Arg Uncertain significance Single submitter
- APLP2 p.His163Tyr Uncertain significance Single submitter
- APLP2 p.His167Leu Uncertain significance Single submitter
- APLP2 p.Leu188Phe Uncertain significance Single submitter
- APLP2 p.Lys124Glu Uncertain significance Single submitter
- APLP2 p.Lys332Asn Uncertain significance Single submitter
- APLP2 p.Lys334Asn Uncertain significance Single submitter
- APLP2 p.Lys420Glu Uncertain significance Single submitter
- APLP2 p.Lys424Arg Uncertain significance Single submitter
- APLP2 p.Lys84Glu Uncertain significance Single submitter
- APLP2 p.Met572Thr Uncertain significance Single submitter
- APLP2 p.Met722Val Uncertain significance Single submitter
- APLP2 p.Pro204Leu Uncertain significance Single submitter
- APLP2 p.Pro368Arg Uncertain significance Single submitter
- APLP2 p.Pro483Ser Uncertain significance Single submitter
- APLP2 p.Pro74Arg Uncertain significance Single submitter
- APLP2 p.Ser447Gly Uncertain significance Single submitter
- APLP2 p.Thr316Met Uncertain significance Single submitter
- APLP2 p.Val139Ile Uncertain significance Single submitter
- APLP2 p.Val374Ile Uncertain significance Single submitter
- APLP2 p.Val698Ile Uncertain significance Single submitter
All APLP2 variants
Benign 2
- c.1923+9G>A Single submitter
- c.922+9A>C Single submitter
Likely benign 4
- p.Arg126His Single submitter
- p.Gly292Ser Single submitter
- p.Leu723= Single submitter
- p.Val235Ile Single submitter
Uncertain significance 130
- p.Val336Leu Multiple submitters ⚠
- c.1837+1543A>G Single submitter ⚠
- c.1837+1550C>T Single submitter ⚠
- c.1837+1564C>A Single submitter ⚠
- c.1837+1564C>T Single submitter ⚠
- c.1837+1567A>G Single submitter ⚠
- c.1837+1571A>G Single submitter ⚠
- p.Ala244Thr Single submitter ⚠
- p.Ala252Val Single submitter ⚠
- p.Ala362Val Single submitter ⚠
- p.Ala36Ser Single submitter ⚠
- p.Ala382Val Single submitter ⚠
- p.Ala415Thr Single submitter ⚠
- p.Ala445Val Single submitter ⚠
- p.Ala53Gly Single submitter ⚠
- p.Ala682Thr Single submitter ⚠
- p.Arg117Trp Single submitter ⚠
- p.Arg126Cys Single submitter ⚠
- p.Arg126Leu Single submitter ⚠
- p.Arg156Gln Single submitter ⚠
- p.Arg271Gln Single submitter ⚠
- p.Arg320Trp Single submitter ⚠
- p.Arg325Cys Single submitter ⚠
- p.Arg325His Single submitter ⚠
- p.Arg337Cys Single submitter ⚠
- p.Arg337His Single submitter ⚠
- p.Arg404Gln Single submitter ⚠
- p.Arg407Gly Single submitter ⚠
- p.Arg485Gln Single submitter ⚠
- p.Arg485Trp Single submitter ⚠
- p.Arg488His Single submitter ⚠
- p.Arg495Cys Single submitter ⚠
- p.Arg495His Single submitter ⚠
- p.Arg498Cys Single submitter ⚠
- p.Arg504Cys Single submitter ⚠
- p.Arg509Cys Single submitter ⚠
- p.Arg569Cys Single submitter ⚠
- p.Arg569His Single submitter ⚠
- p.Arg666Gln Single submitter ⚠
- p.Arg673Trp Single submitter ⚠
- p.Asn349Ser Single submitter ⚠
- p.Asn372Ser Single submitter ⚠
- p.Asn40Ser Single submitter ⚠
- p.Asn465Ser Single submitter ⚠
- p.Asn541His Single submitter ⚠
- p.Asn541Ser Single submitter ⚠
- p.Asn60His Single submitter ⚠
- p.Asn635Ser Single submitter ⚠
- p.Asn655Ser Single submitter ⚠
- p.Asp257Tyr Single submitter ⚠
- p.Asp258Glu Single submitter ⚠
- p.Asp329Asn Single submitter ⚠
- p.Cys123Phe Single submitter ⚠
- p.Cys360Arg Single submitter ⚠
- p.Gln194Glu Single submitter ⚠
- p.Gln542Lys Single submitter ⚠
- p.Glu147Asp Single submitter ⚠
- p.Glu222Gly Single submitter ⚠
- p.Glu224Asp Single submitter ⚠
- p.Glu351Gln Single submitter ⚠
- p.Glu353Val Single submitter ⚠
- p.Glu442Gln Single submitter ⚠
- p.Glu520Gly Single submitter ⚠
- p.Glu592Lys Single submitter ⚠
- p.Glu627Lys Single submitter ⚠
- p.Glu645Gln Single submitter ⚠
- p.Glu657Lys Single submitter ⚠
- p.Glu86Asp Single submitter ⚠
- p.Glu86Val Single submitter ⚠
- p.Gly136Ser Single submitter ⚠
- p.Gly191Arg Single submitter ⚠
- p.Gly210Ala Single submitter ⚠
- p.Gly345Cys Single submitter ⚠
- p.Gly617Arg Single submitter ⚠
- p.His163Tyr Single submitter ⚠
- p.His167Leu Single submitter ⚠
- p.His487Asp Single submitter ⚠
- p.His736Asn Single submitter ⚠
- p.Ile579Val Single submitter ⚠
- p.Ile596Asn Single submitter ⚠
- p.Ile751Val Single submitter ⚠
- p.Leu175Arg Single submitter ⚠
- p.Leu188Phe Single submitter ⚠
- p.Leu608Pro Single submitter ⚠
- p.Leu683Val Single submitter ⚠
- p.Lys124Glu Single submitter ⚠
- p.Lys332Asn Single submitter ⚠
- p.Lys334Asn Single submitter ⚠
- p.Lys420Glu Single submitter ⚠
- p.Lys424Arg Single submitter ⚠
- p.Lys443Glu Single submitter ⚠
- p.Lys84Glu Single submitter ⚠
- p.Met297Val Single submitter ⚠
- p.Met363Thr Single submitter ⚠
- p.Met530Ile Single submitter ⚠
- p.Met572Thr Single submitter ⚠
- p.Met722Val Single submitter ⚠
- p.Met94Leu Single submitter ⚠
- p.Phe599Leu Single submitter ⚠
- p.Phe676Ile Single submitter ⚠
- p.Pro204Leu Single submitter ⚠
- p.Pro288Arg Single submitter ⚠
- p.Pro368Arg Single submitter ⚠
- p.Pro483Ser Single submitter ⚠
- p.Pro484Leu Single submitter ⚠
- p.Pro486Arg Single submitter ⚠
- p.Pro50Ser Single submitter ⚠
- p.Pro598Ser Single submitter ⚠
- p.Pro74Arg Single submitter ⚠
- p.Ser293Thr Single submitter ⚠
- p.Ser447Asn Single submitter ⚠
- p.Ser447Gly Single submitter ⚠
- p.Ser589Gly Single submitter ⚠
- p.Thr289Ala Single submitter ⚠
- p.Thr316Met Single submitter ⚠
- p.Thr380Pro Single submitter ⚠
- p.Tyr233Phe Single submitter ⚠
- p.Tyr33Ser Single submitter ⚠
- p.Tyr340Cys Single submitter ⚠
- p.Tyr709His Single submitter ⚠
- p.Val139Ile Single submitter ⚠
- p.Val145Phe Single submitter ⚠
- p.Val159Met Single submitter ⚠
- p.Val192Ile Single submitter ⚠
- p.Val322Met Single submitter ⚠
- p.Val374Ile Single submitter ⚠
- p.Val586Ile Single submitter ⚠
- p.Val588Met Single submitter ⚠
- p.Val642Ile Single submitter ⚠
- p.Val698Ile Single submitter ⚠