APOBEC1 — 24 ClinVar variants
All ClinVar germline APOBEC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
2 Likely benign · 22 Uncertain significance
Full APOBEC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOBEC1 p.Ala146Gly Uncertain significance Single submitter
- APOBEC1 p.Ala179Thr Uncertain significance Single submitter
- APOBEC1 p.Arg15Gly Uncertain significance Single submitter
- APOBEC1 p.Asn158Asp Uncertain significance Single submitter
- APOBEC1 p.Asp75Gly Uncertain significance Single submitter
- APOBEC1 p.Cys37Arg Uncertain significance Single submitter
- APOBEC1 p.Gly109Asp Uncertain significance Single submitter
- APOBEC1 p.Ile18Val Uncertain significance Single submitter
- APOBEC1 p.Pro172Thr Uncertain significance Single submitter
- APOBEC1 p.Ser89Cys Uncertain significance Single submitter
- APOBEC1 p.Thr217Ala Uncertain significance Single submitter
- APOBEC1 p.Tyr170His Uncertain significance Single submitter
- APOBEC1 p.Val157Phe Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- APOBEC1 p.Arg236Lys Uncertain significance Single submitter
- APOBEC1 p.Arg48Trp Uncertain significance Single submitter
- APOBEC1 p.Asn136Tyr Uncertain significance Single submitter
- APOBEC1 p.His107Gln Uncertain significance Single submitter
- APOBEC1 p.Pro191Arg Uncertain significance Single submitter
- APOBEC1 p.Ser137Gly Uncertain significance Single submitter
- APOBEC1 p.Trp21Cys Uncertain significance Single submitter
- APOBEC1 p.Tyr27His Uncertain significance Single submitter
- APOBEC1 p.Val62Met Uncertain significance Single submitter
All APOBEC1 variants
Likely benign 2
- p.Trp21Ter Single submitter
- p.Val25Ile Single submitter
Uncertain significance 22
- p.Ala146Gly Single submitter ⚠
- p.Ala179Thr Single submitter ⚠
- p.Arg15Gly Single submitter ⚠
- p.Arg236Lys Single submitter ⚠
- p.Arg48Trp Single submitter ⚠
- p.Asn136Tyr Single submitter ⚠
- p.Asn158Asp Single submitter ⚠
- p.Asp75Gly Single submitter ⚠
- p.Cys37Arg Single submitter ⚠
- p.Gly109Asp Single submitter ⚠
- p.His107Gln Single submitter ⚠
- p.Ile18Val Single submitter ⚠
- p.Pro172Thr Single submitter ⚠
- p.Pro191Arg Single submitter ⚠
- p.Ser137Gly Single submitter ⚠
- p.Ser89Cys Single submitter ⚠
- p.Thr217Ala Single submitter ⚠
- p.Trp21Cys Single submitter ⚠
- p.Tyr170His Single submitter ⚠
- p.Tyr27His Single submitter ⚠
- p.Val157Phe Single submitter ⚠
- p.Val62Met Single submitter ⚠