APOBEC2 — 31 ClinVar variants
All ClinVar germline APOBEC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Benign · 2 Likely benign · 28 Uncertain significance
Full APOBEC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOBEC2 p.Ala2Asp Uncertain significance Single submitter
- APOBEC2 p.Ala8Val Uncertain significance Single submitter
- APOBEC2 p.Ala95Val Uncertain significance Single submitter
- APOBEC2 p.Arg46Gln Uncertain significance Single submitter
- APOBEC2 p.Arg46Trp Uncertain significance Single submitter
- APOBEC2 p.Arg57Trp Uncertain significance Single submitter
- APOBEC2 p.Asn17Lys Uncertain significance Single submitter
- APOBEC2 p.Cys71Ser Uncertain significance Single submitter
- APOBEC2 p.Glu100Lys Uncertain significance Single submitter
- APOBEC2 p.Glu22Lys Uncertain significance Single submitter
- APOBEC2 p.Leu148Val Uncertain significance Single submitter
- APOBEC2 p.Leu150Pro Uncertain significance Single submitter
- APOBEC2 p.Lys167Gln Uncertain significance Single submitter
- APOBEC2 p.Trp121Arg Uncertain significance Single submitter
- APOBEC2 p.Trp121Cys Uncertain significance Single submitter
- APOBEC2 p.Tyr214His Uncertain significance Single submitter
- APOBEC2 p.Val74Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- APOBEC2 p.Arg116Trp Uncertain significance Single submitter
- APOBEC2 p.Arg87Trp Uncertain significance Single submitter
- APOBEC2 p.Asn50Lys Uncertain significance Single submitter
- APOBEC2 p.Cys174Ser Uncertain significance Single submitter
- APOBEC2 p.Gln203Arg Uncertain significance Single submitter
- APOBEC2 p.Glu12Lys Uncertain significance Single submitter
- APOBEC2 p.Glu216Lys Uncertain significance Single submitter
- APOBEC2 p.Ile107Thr Uncertain significance Single submitter
- APOBEC2 p.Leu169Val Uncertain significance Single submitter
- APOBEC2 p.Pro109Arg Uncertain significance Single submitter
- APOBEC2 p.Tyr215Asn Uncertain significance Single submitter
All APOBEC2 variants
Benign 1
- p.Ser199Pro Single submitter
Likely benign 2
- p.Ile208Val Single submitter
- p.Phe184= Single submitter
Uncertain significance 28
- p.Ala2Asp Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Ala95Val Single submitter ⚠
- p.Arg116Trp Single submitter ⚠
- p.Arg46Gln Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Arg57Trp Single submitter ⚠
- p.Arg87Trp Single submitter ⚠
- p.Asn17Lys Single submitter ⚠
- p.Asn50Lys Single submitter ⚠
- p.Cys174Ser Single submitter ⚠
- p.Cys71Ser Single submitter ⚠
- p.Gln203Arg Single submitter ⚠
- p.Glu100Lys Single submitter ⚠
- p.Glu12Lys Single submitter ⚠
- p.Glu216Lys Single submitter ⚠
- p.Glu22Lys Single submitter ⚠
- p.Ile107Thr Single submitter ⚠
- p.Leu148Val Single submitter ⚠
- p.Leu150Pro Single submitter ⚠
- p.Leu169Val Single submitter ⚠
- p.Lys167Gln Single submitter ⚠
- p.Pro109Arg Single submitter ⚠
- p.Trp121Arg Single submitter ⚠
- p.Trp121Cys Single submitter ⚠
- p.Tyr214His Single submitter ⚠
- p.Tyr215Asn Single submitter ⚠
- p.Val74Ala Single submitter ⚠