APOBEC3A — 24 ClinVar variants
All ClinVar germline APOBEC3A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
3 Likely benign · 21 Uncertain significance
Full APOBEC3A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOBEC3A p.Ala148Val Uncertain significance Single submitter
- APOBEC3A p.Ala185Asp Uncertain significance Single submitter
- APOBEC3A p.Arg69His Uncertain significance Single submitter
- APOBEC3A p.Asp145Gly Uncertain significance Single submitter
- APOBEC3A p.Gln169Arg Uncertain significance Single submitter
- APOBEC3A p.Gly108Arg Uncertain significance Single submitter
- APOBEC3A p.Gly53Ser Uncertain significance Single submitter
- APOBEC3A p.His16Tyr Uncertain significance Single submitter
- APOBEC3A p.Thr118Ala Uncertain significance Single submitter
- APOBEC3A p.Thr164Ser Uncertain significance Single submitter
- APOBEC3A p.Tyr35Asn Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- APOBEC3A p.Ala107Val Uncertain significance Single submitter
- APOBEC3A p.Arg144Trp Uncertain significance Single submitter
- APOBEC3A p.Arg191Trp Uncertain significance Single submitter
- APOBEC3A p.Cys171Tyr Uncertain significance Single submitter
- APOBEC3A p.Glu36Lys Uncertain significance Single submitter
- APOBEC3A p.Ile152Asn Uncertain significance Single submitter
- APOBEC3A p.Ile96Leu Uncertain significance Single submitter
- APOBEC3A p.Leu194Pro Uncertain significance Single submitter
- APOBEC3A p.Pro86Leu Uncertain significance Single submitter
- APOBEC3A p.Val79Ala Uncertain significance Single submitter
All APOBEC3A variants
Likely benign 3
- p.Arg69Cys Single submitter
- p.Arg74Cys Single submitter
- p.Asn42= Single submitter
Uncertain significance 21
- p.Ala107Val Single submitter ⚠
- p.Ala148Val Single submitter ⚠
- p.Ala185Asp Single submitter ⚠
- p.Arg144Trp Single submitter ⚠
- p.Arg191Trp Single submitter ⚠
- p.Arg69His Single submitter ⚠
- p.Asp145Gly Single submitter ⚠
- p.Cys171Tyr Single submitter ⚠
- p.Gln169Arg Single submitter ⚠
- p.Glu36Lys Single submitter ⚠
- p.Gly108Arg Single submitter ⚠
- p.Gly53Ser Single submitter ⚠
- p.His16Tyr Single submitter ⚠
- p.Ile152Asn Single submitter ⚠
- p.Ile96Leu Single submitter ⚠
- p.Leu194Pro Single submitter ⚠
- p.Pro86Leu Single submitter ⚠
- p.Thr118Ala Single submitter ⚠
- p.Thr164Ser Single submitter ⚠
- p.Tyr35Asn Single submitter ⚠
- p.Val79Ala Single submitter ⚠