APOBEC3B — 54 ClinVar variants
All ClinVar germline APOBEC3B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Conflicting · 3 Benign · 1 Benign/Likely benign · 8 Likely benign · 41 Uncertain significance
Full APOBEC3B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
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APOBEC3B p.Arg351Cys
Conflicting
Single submitter
APOBEC3B-related condition
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOBEC3B p.Ala242Ser Uncertain significance Single submitter
- APOBEC3B p.Ala375Val Uncertain significance Single submitter
- APOBEC3B p.Arg212Leu Uncertain significance Single submitter
- APOBEC3B p.Arg374Trp Uncertain significance Single submitter
- APOBEC3B p.Asp149Asn Uncertain significance Single submitter
- APOBEC3B p.Asp339Gly Uncertain significance Single submitter
- APOBEC3B p.Cys284Tyr Uncertain significance Single submitter
- APOBEC3B p.Cys76Tyr Uncertain significance Single submitter
-
APOBEC3B p.Gln167Pro
Uncertain significance
Single submitter
APOBEC3B-related condition
- APOBEC3B p.Gln357Glu Uncertain significance Single submitter
- APOBEC3B p.Glu187Lys Uncertain significance Single submitter
- APOBEC3B p.Ile41Met Uncertain significance Single submitter
- APOBEC3B p.Leu246Ile Uncertain significance Single submitter
- APOBEC3B p.Phe153Ser Uncertain significance Single submitter
-
APOBEC3B p.Phe296Ser
Uncertain significance
Single submitter
APOBEC3B-related condition
- APOBEC3B p.Pro96Arg Uncertain significance Single submitter
- APOBEC3B p.Ser282Arg Uncertain significance Single submitter
- APOBEC3B p.Thr199Ile Uncertain significance Single submitter
- APOBEC3B p.Tyr28Cys Uncertain significance Single submitter
- APOBEC3B p.Tyr32Cys Uncertain significance Single submitter
- APOBEC3B p.Met235Val Uncertain significance No assertion criteria
Predictors split 22
The independent predictors disagree with each other — read with care.
- APOBEC3B p.Ala331Ser Uncertain significance Single submitter
- APOBEC3B p.Arg183Cys Uncertain significance Single submitter
- APOBEC3B p.Arg183His Likely benign Single submitter
- APOBEC3B p.Arg274Gly Uncertain significance Single submitter
- APOBEC3B p.Arg306His Uncertain significance Single submitter
- APOBEC3B p.Arg327Trp Uncertain significance Single submitter
- APOBEC3B p.Asn201Ser Uncertain significance Single submitter
- APOBEC3B p.Cys97Tyr Uncertain significance Single submitter
- APOBEC3B p.Gln266Lys Uncertain significance Single submitter
- APOBEC3B p.Ile279Ser Uncertain significance Single submitter
- APOBEC3B p.Ile335Asn Uncertain significance Single submitter
- APOBEC3B p.Ile88Leu Benign Single submitter
- APOBEC3B p.Leu267Met Uncertain significance Single submitter
- APOBEC3B p.Leu267Val Uncertain significance Single submitter
- APOBEC3B p.Lys320Asn Uncertain significance Single submitter
- APOBEC3B p.Phe198Leu Uncertain significance Single submitter
- APOBEC3B p.Pro358Thr Uncertain significance Single submitter
- APOBEC3B p.Pro8Arg Uncertain significance Single submitter
- APOBEC3B p.Ser280Thr Uncertain significance Single submitter
- APOBEC3B p.Thr337Ser Uncertain significance Single submitter
- APOBEC3B p.Thr95Ala Uncertain significance Single submitter
- APOBEC3B p.Arg211Trp Likely benign No assertion criteria
All APOBEC3B variants
Conflicting classifications of pathogenicity 1
- p.Arg351Cys Single submitter APOBEC3B-related condition ⚠
Benign 3
- p.Asn23= Multiple submitters
- p.Pro206= Multiple submitters
- p.Ile88Leu Single submitter ⚠
Benign/Likely benign 1
- p.Ser109Ala Multiple submitters APOBEC3B-related condition
Likely benign 8
- p.Arg183His Single submitter ⚠
- p.Arg374Gln Single submitter
- p.Arg45Cys Single submitter
- p.Cys85Arg Single submitter
- p.Glu152Asp Single submitter
- p.Arg211Trp No assertion criteria ⚠
- p.Arg351His No assertion criteria
- p.Glu342Asp No assertion criteria
Uncertain significance 41
- c.174+1G>T Single submitter
- p.Ala242Ser Single submitter ⚠
- p.Ala331Ser Single submitter ⚠
- p.Ala375Val Single submitter ⚠
- p.Arg183Cys Single submitter ⚠
- p.Arg212Leu Single submitter ⚠
- p.Arg274Gly Single submitter ⚠
- p.Arg306His Single submitter ⚠
- p.Arg327Trp Single submitter ⚠
- p.Arg374Trp Single submitter ⚠
- p.Asn201Ser Single submitter ⚠
- p.Asp149Asn Single submitter ⚠
- p.Asp339Gly Single submitter ⚠
- p.Cys284Tyr Single submitter ⚠
- p.Cys76Tyr Single submitter ⚠
- p.Cys97Tyr Single submitter ⚠
- p.Gln167Pro Single submitter APOBEC3B-related condition ⚠
- p.Gln266Lys Single submitter ⚠
- p.Gln357Glu Single submitter ⚠
- p.Glu187Lys Single submitter ⚠
- p.Ile279Ser Single submitter ⚠
- p.Ile335Asn Single submitter ⚠
- p.Ile41Met Single submitter ⚠
- p.Leu246Ile Single submitter ⚠
- p.Leu267Met Single submitter ⚠
- p.Leu267Val Single submitter ⚠
- p.Lys320Asn Single submitter ⚠
- p.Phe153Ser Single submitter ⚠
- p.Phe198Leu Single submitter ⚠
- p.Phe296Ser Single submitter APOBEC3B-related condition ⚠
- p.Pro358Thr Single submitter ⚠
- p.Pro8Arg Single submitter ⚠
- p.Pro96Arg Single submitter ⚠
- p.Ser280Thr Single submitter ⚠
- p.Ser282Arg Single submitter ⚠
- p.Thr199Ile Single submitter ⚠
- p.Thr337Ser Single submitter ⚠
- p.Thr95Ala Single submitter ⚠
- p.Tyr28Cys Single submitter ⚠
- p.Tyr32Cys Single submitter ⚠
- p.Met235Val No assertion criteria ⚠