APOBEC3C — 29 ClinVar variants
All ClinVar germline APOBEC3C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
1 Benign · 1 Likely benign · 27 Uncertain significance
Full APOBEC3C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOBEC3C p.Asn165Lys Uncertain significance Single submitter
- APOBEC3C p.Asp78Glu Uncertain significance Single submitter
- APOBEC3C p.Cys36Arg Uncertain significance Single submitter
- APOBEC3C p.Cys70Trp Uncertain significance Single submitter
- APOBEC3C p.Met12Val Uncertain significance Single submitter
- APOBEC3C p.Phe19Val Uncertain significance Single submitter
- APOBEC3C p.Ser49Cys Uncertain significance Single submitter
- APOBEC3C p.Ser93Tyr Uncertain significance Single submitter
- APOBEC3C p.Thr176Asn Uncertain significance Single submitter
- APOBEC3C p.Thr52Ser Uncertain significance Single submitter
- APOBEC3C p.Thr92Ile Uncertain significance Single submitter
- APOBEC3C p.Trp171Cys Uncertain significance Single submitter
- APOBEC3C p.Trp25Arg Uncertain significance Single submitter
- APOBEC3C p.Tyr13Ser Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- APOBEC3C p.Arg186Trp Uncertain significance Single submitter
- APOBEC3C p.Arg30Trp Uncertain significance Single submitter
- APOBEC3C p.Glu146Gln Uncertain significance Single submitter
- APOBEC3C p.Gly134Ala Uncertain significance Single submitter
- APOBEC3C p.Gly53Val Uncertain significance Single submitter
- APOBEC3C p.His66Tyr Uncertain significance Single submitter
- APOBEC3C p.Ile147Asn Uncertain significance Single submitter
- APOBEC3C p.Ser95Ile Uncertain significance Single submitter
- APOBEC3C p.Thr52Met Uncertain significance Single submitter
- APOBEC3C p.Trp34Arg Uncertain significance Single submitter
- APOBEC3C p.Tyr124Cys Uncertain significance Single submitter
- APOBEC3C p.Tyr86Asn Uncertain significance Single submitter
- APOBEC3C p.Val114Met Uncertain significance Single submitter
All APOBEC3C variants
Benign 1
- p.Ser188Ile Multiple submitters
Likely benign 1
- p.His64Pro Single submitter
Uncertain significance 27
- p.Arg186Trp Single submitter ⚠
- p.Arg30Trp Single submitter ⚠
- p.Asn165Lys Single submitter ⚠
- p.Asp78Glu Single submitter ⚠
- p.Cys36Arg Single submitter ⚠
- p.Cys70Trp Single submitter ⚠
- p.Glu146Gln Single submitter ⚠
- p.Gly134Ala Single submitter ⚠
- p.Gly53Val Single submitter ⚠
- p.His66Tyr Single submitter ⚠
- p.Ile147Asn Single submitter ⚠
- p.Met12Val Single submitter ⚠
- p.Phe19Val Single submitter ⚠
- p.Ser49Cys Single submitter ⚠
- p.Ser93Tyr Single submitter ⚠
- p.Ser95Ile Single submitter ⚠
- p.Thr176Asn Single submitter ⚠
- p.Thr52Met Single submitter ⚠
- p.Thr52Ser Single submitter ⚠
- p.Thr92Ile Single submitter ⚠
- p.Trp171Cys Single submitter ⚠
- p.Trp25Arg Single submitter ⚠
- p.Trp34Arg Single submitter ⚠
- p.Tyr124Cys Single submitter ⚠
- p.Tyr13Ser Single submitter ⚠
- p.Tyr86Asn Single submitter ⚠
- p.Val114Met Single submitter ⚠