APOBEC3G — 38 ClinVar variants
All ClinVar germline APOBEC3G variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
2 Likely benign · 36 Uncertain significance
Full APOBEC3G gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOBEC3G p.Ala312Val Uncertain significance Single submitter
- APOBEC3G p.Arg69Lys Uncertain significance Single submitter
- APOBEC3G p.Arg82His Uncertain significance Single submitter
- APOBEC3G p.Asn236Lys Uncertain significance Single submitter
- APOBEC3G p.Gln369Arg Uncertain significance Single submitter
- APOBEC3G p.Glu67Lys Uncertain significance Single submitter
- APOBEC3G p.His72Asp Uncertain significance Single submitter
- APOBEC3G p.Ile335Val Uncertain significance Single submitter
- APOBEC3G p.Leu242Ile Uncertain significance Single submitter
- APOBEC3G p.Leu273Pro Uncertain significance Single submitter
- APOBEC3G p.Met227Arg Uncertain significance Single submitter
- APOBEC3G p.Met227Val Uncertain significance Single submitter
- APOBEC3G p.Tyr124Asn Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- APOBEC3G p.Ala134Val Uncertain significance Single submitter
- APOBEC3G p.Ala333Asp Uncertain significance Single submitter
- APOBEC3G p.Arg122Cys Uncertain significance Single submitter
- APOBEC3G p.Arg136Cys Uncertain significance Single submitter
- APOBEC3G p.Arg30Trp Uncertain significance Single submitter
- APOBEC3G p.Arg313His Uncertain significance Single submitter
- APOBEC3G p.Arg326Cys Uncertain significance Single submitter
- APOBEC3G p.Asp272Tyr Uncertain significance Single submitter
- APOBEC3G p.Glu225Asp Uncertain significance Single submitter
- APOBEC3G p.Glu366Ala Uncertain significance Single submitter
- APOBEC3G p.Gly251Ser Uncertain significance Single submitter
- APOBEC3G p.Gly355Val Uncertain significance Single submitter
- APOBEC3G p.His345Gln Uncertain significance Single submitter
- APOBEC3G p.Ile151Phe Uncertain significance Single submitter
- APOBEC3G p.Ile266Met Uncertain significance Single submitter
- APOBEC3G p.Met12Ile Uncertain significance Single submitter
- APOBEC3G p.Met197Val Uncertain significance Single submitter
- APOBEC3G p.Met295Leu Likely benign Single submitter
- APOBEC3G p.Phe157Tyr Uncertain significance Single submitter
- APOBEC3G p.Phe282Val Uncertain significance Single submitter
- APOBEC3G p.Phe298Leu Uncertain significance Single submitter
- APOBEC3G p.Phe358Val Uncertain significance Single submitter
- APOBEC3G p.Ser75Thr Uncertain significance Single submitter
- APOBEC3G p.Val114Ile Uncertain significance Single submitter
All APOBEC3G variants
Likely benign 2
- p.Met295Leu Single submitter ⚠
- p.Phe204Ser Single submitter
Uncertain significance 36
- p.Ala134Val Single submitter ⚠
- p.Ala312Val Single submitter ⚠
- p.Ala333Asp Single submitter ⚠
- p.Arg122Cys Single submitter ⚠
- p.Arg136Cys Single submitter ⚠
- p.Arg30Trp Single submitter ⚠
- p.Arg313His Single submitter ⚠
- p.Arg326Cys Single submitter ⚠
- p.Arg69Lys Single submitter ⚠
- p.Arg82His Single submitter ⚠
- p.Asn236Lys Single submitter ⚠
- p.Asp272Tyr Single submitter ⚠
- p.Gln369Arg Single submitter ⚠
- p.Glu225Asp Single submitter ⚠
- p.Glu366Ala Single submitter ⚠
- p.Glu67Lys Single submitter ⚠
- p.Gly251Ser Single submitter ⚠
- p.Gly355Val Single submitter ⚠
- p.His345Gln Single submitter ⚠
- p.His72Asp Single submitter ⚠
- p.Ile151Phe Single submitter ⚠
- p.Ile266Met Single submitter ⚠
- p.Ile335Val Single submitter ⚠
- p.Leu242Ile Single submitter ⚠
- p.Leu273Pro Single submitter ⚠
- p.Met12Ile Single submitter ⚠
- p.Met197Val Single submitter ⚠
- p.Met227Arg Single submitter ⚠
- p.Met227Val Single submitter ⚠
- p.Phe157Tyr Single submitter ⚠
- p.Phe282Val Single submitter ⚠
- p.Phe298Leu Single submitter ⚠
- p.Phe358Val Single submitter ⚠
- p.Ser75Thr Single submitter ⚠
- p.Tyr124Asn Single submitter ⚠
- p.Val114Ile Single submitter ⚠