APOBEC3H — 30 ClinVar variants
All ClinVar germline APOBEC3H variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
1 Benign · 3 Likely benign · 26 Uncertain significance
Full APOBEC3H gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOBEC3H p.Arg10Cys Uncertain significance Single submitter
- APOBEC3H p.Arg10His Uncertain significance Single submitter
- APOBEC3H p.Arg17His Uncertain significance Single submitter
- APOBEC3H p.Cys116Trp Uncertain significance Single submitter
- APOBEC3H p.Gly105Val Uncertain significance Single submitter
- APOBEC3H p.Gly122Arg Uncertain significance Single submitter
- APOBEC3H p.Gly122Trp Uncertain significance Single submitter
- APOBEC3H p.Ile96Val Uncertain significance Single submitter
- APOBEC3H p.Pro132Leu Uncertain significance Single submitter
- APOBEC3H p.Ser65Thr Uncertain significance Single submitter
- APOBEC3H p.Thr35Ser Uncertain significance Single submitter
- APOBEC3H p.Tyr160Asp Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- APOBEC3H p.Arg110His Uncertain significance Single submitter
- APOBEC3H p.Arg124Gln Likely benign Single submitter
- APOBEC3H p.Arg17Cys Uncertain significance Single submitter
- APOBEC3H p.Glu146Gly Uncertain significance Single submitter
- APOBEC3H p.Glu48Gly Uncertain significance Single submitter
- APOBEC3H p.Gly137Ala Uncertain significance Single submitter
- APOBEC3H p.Gly45Val Uncertain significance Single submitter
- APOBEC3H p.Met66Val Uncertain significance Single submitter
- APOBEC3H p.Pro36Ser Uncertain significance Single submitter
- APOBEC3H p.Ser129Thr Uncertain significance Single submitter
- APOBEC3H p.Ser86Phe Uncertain significance Single submitter
- APOBEC3H p.Thr41Met Uncertain significance Single submitter
- APOBEC3H p.Thr81Met Uncertain significance Single submitter
- APOBEC3H p.Tyr112His Uncertain significance Single submitter
- APOBEC3H p.Tyr113Cys Uncertain significance Single submitter
All APOBEC3H variants
Benign 1
- p.Phe107= Multiple submitters
Likely benign 3
- p.Ala108Thr Single submitter
- p.Arg124Gln Single submitter ⚠
- p.Phe138= Single submitter
Uncertain significance 26
- p.Arg10Cys Single submitter ⚠
- p.Arg10His Single submitter ⚠
- p.Arg110His Single submitter ⚠
- p.Arg17Cys Single submitter ⚠
- p.Arg17His Single submitter ⚠
- p.Cys116Trp Single submitter ⚠
- p.Glu146Gly Single submitter ⚠
- p.Glu48Gly Single submitter ⚠
- p.Gly105Val Single submitter ⚠
- p.Gly122Arg Single submitter ⚠
- p.Gly122Trp Single submitter ⚠
- p.Gly137Ala Single submitter ⚠
- p.Gly45Val Single submitter ⚠
- p.Ile96Val Single submitter ⚠
- p.Met66Val Single submitter ⚠
- p.Pro132Leu Single submitter ⚠
- p.Pro36Ser Single submitter ⚠
- p.Ser129Thr Single submitter ⚠
- p.Ser65Thr Single submitter ⚠
- p.Ser86Phe Single submitter ⚠
- p.Thr35Ser Single submitter ⚠
- p.Thr41Met Single submitter ⚠
- p.Thr81Met Single submitter ⚠
- p.Tyr112His Single submitter ⚠
- p.Tyr113Cys Single submitter ⚠
- p.Tyr160Asp Single submitter ⚠