APOBEC4 — 52 ClinVar variants
All ClinVar germline APOBEC4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
4 Benign · 4 Likely benign · 44 Uncertain significance
Full APOBEC4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOBEC4 p.Ala231Asp Uncertain significance Single submitter
- APOBEC4 p.Arg318Lys Uncertain significance Single submitter
- APOBEC4 p.Arg335Ser Uncertain significance Single submitter
- APOBEC4 p.Arg36Leu Uncertain significance Single submitter
- APOBEC4 p.Asn131Lys Uncertain significance Single submitter
- APOBEC4 p.Asn282His Uncertain significance Single submitter
- APOBEC4 p.Asn321Lys Uncertain significance Single submitter
- APOBEC4 p.Asp27Asn Uncertain significance Single submitter
- APOBEC4 p.Glu356Lys Uncertain significance Single submitter
- APOBEC4 p.Glu95Lys Uncertain significance Single submitter
- APOBEC4 p.Gly307Ser Uncertain significance Single submitter
- APOBEC4 p.His159Arg Uncertain significance Single submitter
- APOBEC4 p.Ile118Thr Uncertain significance Single submitter
- APOBEC4 p.Ile202Thr Uncertain significance Single submitter
- APOBEC4 p.Ile316Leu Uncertain significance Single submitter
- APOBEC4 p.Leu177Pro Uncertain significance Single submitter
- APOBEC4 p.Leu45Phe Uncertain significance Single submitter
- APOBEC4 p.Met274Ile Uncertain significance Single submitter
- APOBEC4 p.Met304Arg Uncertain significance Single submitter
- APOBEC4 p.Phe211Tyr Uncertain significance Single submitter
- APOBEC4 p.Pro182Leu Uncertain significance Single submitter
- APOBEC4 p.Pro313Ser Uncertain significance Single submitter
- APOBEC4 p.Ser353Thr Uncertain significance Single submitter
- APOBEC4 p.Ser74Thr Uncertain significance Single submitter
- APOBEC4 p.Ser77Gly Uncertain significance Single submitter
- APOBEC4 p.Thr58Ile Uncertain significance Single submitter
- APOBEC4 p.Tyr227Cys Uncertain significance Single submitter
- APOBEC4 p.Val235Ile Uncertain significance Single submitter
- APOBEC4 p.Val242Ile Uncertain significance Single submitter
- APOBEC4 p.Val294Glu Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- APOBEC4 p.Ser196Cys Benign Multiple submitters
- APOBEC4 p.Arg175Gln Uncertain significance Single submitter
- APOBEC4 p.Arg175Trp Uncertain significance Single submitter
- APOBEC4 p.Arg335Trp Uncertain significance Single submitter
- APOBEC4 p.Cys31Phe Uncertain significance Single submitter
- APOBEC4 p.Glu172Lys Uncertain significance Single submitter
- APOBEC4 p.Glu228Asp Uncertain significance Single submitter
- APOBEC4 p.Gly204Ser Uncertain significance Single submitter
- APOBEC4 p.Leu180Ser Uncertain significance Single submitter
- APOBEC4 p.Phe211Leu Uncertain significance Single submitter
- APOBEC4 p.Ser151Asn Uncertain significance Single submitter
- APOBEC4 p.Ser86Gly Uncertain significance Single submitter
- APOBEC4 p.Thr144Met Likely benign Single submitter
- APOBEC4 p.Thr46Ile Uncertain significance Single submitter
- APOBEC4 p.Tyr5His Uncertain significance Single submitter
- APOBEC4 p.Val184Ala Uncertain significance Single submitter
All APOBEC4 variants
Benign 4
- p.Asn321Asp Multiple submitters
- p.Asp300Gly Multiple submitters
- p.Pro182= Multiple submitters
- p.Ser196Cys Multiple submitters ⚠
Likely benign 4
- p.Ala289Val Single submitter
- p.Gly334Glu Single submitter
- p.Ile202Val Single submitter
- p.Thr144Met Single submitter ⚠
Uncertain significance 44
- p.Ala231Asp Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Arg175Trp Single submitter ⚠
- p.Arg318Lys Single submitter ⚠
- p.Arg335Ser Single submitter ⚠
- p.Arg335Trp Single submitter ⚠
- p.Arg36Leu Single submitter ⚠
- p.Asn131Lys Single submitter ⚠
- p.Asn282His Single submitter ⚠
- p.Asn321Lys Single submitter ⚠
- p.Asp27Asn Single submitter ⚠
- p.Cys31Phe Single submitter ⚠
- p.Glu172Lys Single submitter ⚠
- p.Glu228Asp Single submitter ⚠
- p.Glu356Lys Single submitter ⚠
- p.Glu95Lys Single submitter ⚠
- p.Gly204Ser Single submitter ⚠
- p.Gly307Ser Single submitter ⚠
- p.His159Arg Single submitter ⚠
- p.Ile118Thr Single submitter ⚠
- p.Ile202Thr Single submitter ⚠
- p.Ile316Leu Single submitter ⚠
- p.Leu177Pro Single submitter ⚠
- p.Leu180Ser Single submitter ⚠
- p.Leu45Phe Single submitter ⚠
- p.Met274Ile Single submitter ⚠
- p.Met304Arg Single submitter ⚠
- p.Phe211Leu Single submitter ⚠
- p.Phe211Tyr Single submitter ⚠
- p.Pro182Leu Single submitter ⚠
- p.Pro313Ser Single submitter ⚠
- p.Ser151Asn Single submitter ⚠
- p.Ser353Thr Single submitter ⚠
- p.Ser74Thr Single submitter ⚠
- p.Ser77Gly Single submitter ⚠
- p.Ser86Gly Single submitter ⚠
- p.Thr46Ile Single submitter ⚠
- p.Thr58Ile Single submitter ⚠
- p.Tyr227Cys Single submitter ⚠
- p.Tyr5His Single submitter ⚠
- p.Val184Ala Single submitter ⚠
- p.Val235Ile Single submitter ⚠
- p.Val242Ile Single submitter ⚠
- p.Val294Glu Single submitter ⚠