APOC1 — 9 ClinVar variants
All ClinVar germline APOC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
1 Likely benign · 8 Uncertain significance
Full APOC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 3
The independent predictors disagree with each other — read with care.
All APOC1 variants
Likely benign 1
- p.Glu66Asp Single submitter
Uncertain significance 8
- p.Arg49Gly Single submitter ⚠
- p.Asn42Lys Single submitter ⚠
- p.Ile81Met Single submitter ⚠
- p.Leu14Pro Single submitter ⚠
- p.Leu37Arg Single submitter ⚠
- p.Leu3Phe Single submitter ⚠
- p.Thr43Ile Single submitter ⚠
- p.Val30Ile Single submitter ⚠