APOC4 — 26 ClinVar variants
All ClinVar germline APOC4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
7 Likely benign · 19 Uncertain significance
Full APOC4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOC4 p.Arg118Thr Uncertain significance Single submitter
- APOC4 p.Arg64Gly Uncertain significance Single submitter
- APOC4 p.Arg79Trp Uncertain significance Single submitter
- APOC4 p.Asp88Asn Uncertain significance Single submitter
- APOC4 p.Asp88His Uncertain significance Single submitter
- APOC4 p.Cys23Tyr Uncertain significance Single submitter
- APOC4 p.Gln70Arg Uncertain significance Single submitter
- APOC4 p.Ile24Phe Uncertain significance Single submitter
- APOC4 p.Met82Thr Uncertain significance Single submitter
- APOC4 p.Pro39Arg Uncertain significance Single submitter
- APOC4 p.Pro39Gln Uncertain significance Single submitter
- APOC4 p.Thr65Ala Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- APOC4 p.Ala99Val Uncertain significance Single submitter
- APOC4 p.Gly68Glu Uncertain significance Single submitter
- APOC4 p.Ile24Thr Uncertain significance Single submitter
- APOC4 p.Leu16Phe Likely benign Single submitter
- APOC4 p.Leu3Phe Uncertain significance Single submitter
- APOC4 p.Leu4Phe Uncertain significance Single submitter
- APOC4 p.Pro117Leu Uncertain significance Single submitter
- APOC4 p.Pro12Leu Uncertain significance Single submitter
All APOC4 variants
Likely benign 7
- p.Arg46His Single submitter
- p.Glu103Lys Single submitter
- p.Gly127Asp Single submitter
- p.Gly52Asp Single submitter
- p.Leu119Ile Single submitter
- p.Leu16Phe Single submitter ⚠
- p.Met82Val Single submitter
Uncertain significance 19
- p.Ala99Val Single submitter ⚠
- p.Arg118Thr Single submitter ⚠
- p.Arg64Gly Single submitter ⚠
- p.Arg79Trp Single submitter ⚠
- p.Asp88Asn Single submitter ⚠
- p.Asp88His Single submitter ⚠
- p.Cys23Tyr Single submitter ⚠
- p.Gln70Arg Single submitter ⚠
- p.Gly68Glu Single submitter ⚠
- p.Ile24Phe Single submitter ⚠
- p.Ile24Thr Single submitter ⚠
- p.Leu3Phe Single submitter ⚠
- p.Leu4Phe Single submitter ⚠
- p.Met82Thr Single submitter ⚠
- p.Pro117Leu Single submitter ⚠
- p.Pro12Leu Single submitter ⚠
- p.Pro39Arg Single submitter ⚠
- p.Pro39Gln Single submitter ⚠
- p.Thr65Ala Single submitter ⚠