APOD — 33 ClinVar variants
All ClinVar germline APOD variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
3 Benign · 6 Likely benign · 24 Uncertain significance
Full APOD gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOD p.Gln139Glu Uncertain significance Single submitter
- APOD p.Glu48Lys Uncertain significance Single submitter
- APOD p.Glu57Lys Uncertain significance Single submitter
- APOD p.Gly44Arg Uncertain significance Single submitter
- APOD p.Gly92Arg Uncertain significance Single submitter
- APOD p.Leu11Val Uncertain significance Single submitter
- APOD p.Pro117Leu Uncertain significance Single submitter
- APOD p.Pro53Ser Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- APOD p.Ala146Thr Uncertain significance Single submitter
- APOD p.Ala17Glu Uncertain significance Single submitter
- APOD p.Arg60Cys Uncertain significance Single submitter
- APOD p.Asp124Asn Uncertain significance Single submitter
- APOD p.Gln34Arg Uncertain significance Single submitter
- APOD p.Gln79Glu Uncertain significance Single submitter
- APOD p.Ile49Val Uncertain significance Single submitter
- APOD p.Leu25Pro Uncertain significance Single submitter
- APOD p.Lys41Thr Uncertain significance Single submitter
- APOD p.Met177Ile Uncertain significance Single submitter
- APOD p.Phe23Leu Uncertain significance Single submitter
- APOD p.Pro102Ala Uncertain significance Single submitter
- APOD p.Pro29Ser Uncertain significance Single submitter
- APOD p.Thr135Ile Uncertain significance Single submitter
- APOD p.Thr54Pro Uncertain significance Single submitter
- APOD p.Val87Ala Uncertain significance Single submitter
All APOD variants
Benign 3
- p.Phe15Ser Multiple submitters
- p.Val76Met Single submitter
- p.Phe56Val No assertion criteria APOD-related disorder
Likely benign 6
- p.Ala22Thr Single submitter
- p.Asn30Ser Single submitter
- p.Lys187Glu Single submitter
- p.Thr55= Single submitter
- p.Val143Met Single submitter
- p.Tyr128Cys No assertion criteria APOD-related disorder
Uncertain significance 24
- p.Ala146Thr Single submitter ⚠
- p.Ala17Glu Single submitter ⚠
- p.Arg60Cys Single submitter ⚠
- p.Asp124Asn Single submitter ⚠
- p.Gln139Glu Single submitter ⚠
- p.Gln34Arg Single submitter ⚠
- p.Gln79Glu Single submitter ⚠
- p.Glu48Lys Single submitter ⚠
- p.Glu57Lys Single submitter ⚠
- p.Gly44Arg Single submitter ⚠
- p.Gly92Arg Single submitter ⚠
- p.Ile49Val Single submitter ⚠
- p.Leu11Val Single submitter ⚠
- p.Leu25Pro Single submitter ⚠
- p.Lys41Thr Single submitter ⚠
- p.Met177Ile Single submitter ⚠
- p.Phe23Leu Single submitter ⚠
- p.Pro102Ala Single submitter ⚠
- p.Pro117Leu Single submitter ⚠
- p.Pro29Ser Single submitter ⚠
- p.Pro53Ser Single submitter ⚠
- p.Thr135Ile Single submitter ⚠
- p.Thr54Pro Single submitter ⚠
- p.Val87Ala Single submitter ⚠