APOF — 44 ClinVar variants
All ClinVar germline APOF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
1 Benign · 1 Likely benign · 42 Uncertain significance
Full APOF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOF p.Ala106Thr Uncertain significance Single submitter
- APOF p.Ala144Val Uncertain significance Single submitter
- APOF p.Ala148Thr Uncertain significance Single submitter
- APOF p.Ala153Ser Uncertain significance Single submitter
- APOF p.Ala153Val Uncertain significance Single submitter
- APOF p.Ala266Thr Uncertain significance Single submitter
- APOF p.Ala321Ser Uncertain significance Single submitter
- APOF p.Arg138Ser Uncertain significance Single submitter
- APOF p.Asn139Ser Uncertain significance Single submitter
- APOF p.Asp35Asn Uncertain significance Single submitter
- APOF p.Gln114Arg Uncertain significance Single submitter
- APOF p.Gln157Glu Uncertain significance Single submitter
- APOF p.Gln184Glu Uncertain significance Single submitter
- APOF p.Gln258Arg Uncertain significance Single submitter
- APOF p.Gln56His Uncertain significance Single submitter
- APOF p.Glu325Lys Uncertain significance Single submitter
- APOF p.Gly208Val Uncertain significance Single submitter
- APOF p.His32Leu Uncertain significance Single submitter
- APOF p.Leu166Ile Uncertain significance Single submitter
- APOF p.Leu17Phe Uncertain significance Single submitter
- APOF p.Leu26Val Uncertain significance Single submitter
- APOF p.Lys175Asn Uncertain significance Single submitter
- APOF p.Met232Ile Uncertain significance Single submitter
- APOF p.Phe49Ser Uncertain significance Single submitter
- APOF p.Pro62Arg Uncertain significance Single submitter
- APOF p.Ser233Leu Uncertain significance Single submitter
- APOF p.Thr228Ile Uncertain significance Single submitter
- APOF p.Thr2Ala Uncertain significance Single submitter
- APOF p.Trp307Gly Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- APOF p.Arg250Ser Uncertain significance Single submitter
- APOF p.Gln121His Uncertain significance Single submitter
- APOF p.Glu155Lys Uncertain significance Single submitter
- APOF p.Glu212Gly Uncertain significance Single submitter
- APOF p.Glu96Asp Uncertain significance Single submitter
- APOF p.Gly133Ser Uncertain significance Single submitter
- APOF p.Gly252Arg Uncertain significance Single submitter
- APOF p.Ile219Thr Uncertain significance Single submitter
- APOF p.Leu166Phe Uncertain significance Single submitter
- APOF p.Met229Ile Uncertain significance Single submitter
- APOF p.Pro81Ser Uncertain significance Single submitter
- APOF p.Thr197Ala Uncertain significance Single submitter
- APOF p.Thr203Ile Uncertain significance Single submitter
All APOF variants
Benign 1
- p.Arg113His Multiple submitters
Likely benign 1
- p.Ala240Val Single submitter
Uncertain significance 42
- p.Ala106Thr Single submitter ⚠
- p.Ala144Val Single submitter ⚠
- p.Ala148Thr Single submitter ⚠
- p.Ala153Ser Single submitter ⚠
- p.Ala153Val Single submitter ⚠
- p.Ala266Thr Single submitter ⚠
- p.Ala321Ser Single submitter ⚠
- p.Arg138Ser Single submitter ⚠
- p.Arg250Ser Single submitter ⚠
- p.Asn139Ser Single submitter ⚠
- p.Asp35Asn Single submitter ⚠
- p.Gln114Arg Single submitter ⚠
- p.Gln121His Single submitter ⚠
- p.Gln157Glu Single submitter ⚠
- p.Gln184Glu Single submitter ⚠
- p.Gln258Arg Single submitter ⚠
- p.Gln56His Single submitter ⚠
- p.Glu155Lys Single submitter ⚠
- p.Glu212Gly Single submitter ⚠
- p.Glu325Lys Single submitter ⚠
- p.Glu96Asp Single submitter ⚠
- p.Gly133Ser Single submitter ⚠
- p.Gly208Val Single submitter ⚠
- p.Gly252Arg Single submitter ⚠
- p.His32Leu Single submitter ⚠
- p.Ile219Thr Single submitter ⚠
- p.Leu166Ile Single submitter ⚠
- p.Leu166Phe Single submitter ⚠
- p.Leu17Phe Single submitter ⚠
- p.Leu26Val Single submitter ⚠
- p.Lys175Asn Single submitter ⚠
- p.Met229Ile Single submitter ⚠
- p.Met232Ile Single submitter ⚠
- p.Phe49Ser Single submitter ⚠
- p.Pro62Arg Single submitter ⚠
- p.Pro81Ser Single submitter ⚠
- p.Ser233Leu Single submitter ⚠
- p.Thr197Ala Single submitter ⚠
- p.Thr203Ile Single submitter ⚠
- p.Thr228Ile Single submitter ⚠
- p.Thr2Ala Single submitter ⚠
- p.Trp307Gly Single submitter ⚠