APOH — 38 ClinVar variants
All ClinVar germline APOH variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Likely pathogenic · 9 Benign · 1 Likely benign · 27 Uncertain significance
Full APOH gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOH p.Ala179Val Uncertain significance Single submitter
- APOH p.Ala333Val Uncertain significance Single submitter
- APOH p.Cys23Phe Uncertain significance Single submitter
- APOH p.Cys264Phe Uncertain significance Single submitter
- APOH p.Cys300Tyr Uncertain significance Single submitter
- APOH p.Cys307Tyr Uncertain significance Single submitter
- APOH p.Cys325Phe Uncertain significance Single submitter
- APOH p.Cys79Tyr Uncertain significance Single submitter
- APOH p.Gly182Arg Uncertain significance Single submitter
- APOH p.Ile106Thr Uncertain significance Single submitter
- APOH p.Ile316Val Uncertain significance Single submitter
- APOH p.Lys269Glu Uncertain significance Single submitter
- APOH p.Pro211Ser Uncertain significance Single submitter
- APOH p.Pro323Ser Uncertain significance Single submitter
- APOH p.Thr195Ile Uncertain significance Single submitter
- APOH p.Trp194Cys Uncertain significance Single submitter
- APOH p.Tyr41Cys Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- APOH p.Arg154His Benign Multiple submitters
- APOH p.Ala170Thr Uncertain significance Single submitter
- APOH p.Ala230Thr Uncertain significance Single submitter
- APOH p.Phe286Leu Uncertain significance Single submitter
- APOH p.Phe86Ser Uncertain significance Single submitter
- APOH p.Pro81His Uncertain significance Single submitter
- APOH p.Ser10Trp Uncertain significance Single submitter
- APOH p.Thr105Lys Uncertain significance Single submitter
- APOH p.Thr125Ile Uncertain significance Single submitter
- APOH p.Tyr156Cys Uncertain significance Single submitter
- APOH p.Tyr218His Uncertain significance Single submitter
All APOH variants
Likely pathogenic 1
- p.Lys38Glu No assertion criteria ⚠
Benign 9
- c.64+8C>T Multiple submitters
- p.Ala160Asp Multiple submitters
- p.Arg154His Multiple submitters ⚠
- p.Asn75Ser Multiple submitters
- p.Pro53= Multiple submitters
- c.338+10T>G Single submitter
- p.Pro132= Single submitter
- p.Ser159= Single submitter
- p.Val266Leu Single submitter
Likely benign 1
- p.Ala119Thr Single submitter
Uncertain significance 27
- p.Ala170Thr Single submitter ⚠
- p.Ala179Val Single submitter ⚠
- p.Ala230Thr Single submitter ⚠
- p.Ala333Val Single submitter ⚠
- p.Cys23Phe Single submitter ⚠
- p.Cys264Phe Single submitter ⚠
- p.Cys300Tyr Single submitter ⚠
- p.Cys307Tyr Single submitter ⚠
- p.Cys325Phe Single submitter ⚠
- p.Cys79Tyr Single submitter ⚠
- p.Gly182Arg Single submitter ⚠
- p.Ile106Thr Single submitter ⚠
- p.Ile316Val Single submitter ⚠
- p.Lys269Glu Single submitter ⚠
- p.Phe286Leu Single submitter ⚠
- p.Phe86Ser Single submitter ⚠
- p.Pro211Ser Single submitter ⚠
- p.Pro323Ser Single submitter ⚠
- p.Pro81His Single submitter ⚠
- p.Ser10Trp Single submitter ⚠
- p.Thr105Lys Single submitter ⚠
- p.Thr125Ile Single submitter ⚠
- p.Thr195Ile Single submitter ⚠
- p.Trp194Cys Single submitter ⚠
- p.Tyr156Cys Single submitter ⚠
- p.Tyr218His Single submitter ⚠
- p.Tyr41Cys Single submitter ⚠