APOL1 — 188 ClinVar variants
All ClinVar germline APOL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 92 flagged for review →
4 Conflicting · 39 Benign · 9 Benign/Likely benign · 44 Likely benign · 92 Uncertain significance
Full APOL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 92
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 4
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOL1 p.Ala108Glu Uncertain significance Multiple submitters
-
APOL1 p.Ala394Gly
Uncertain significance
Multiple submitters
focal segmental glomerulosclerosis 4, susceptibility to
- APOL1 p.Asp46Gly Uncertain significance Multiple submitters
-
APOL1 p.Glu323Gln
Uncertain significance
Multiple submitters
focal segmental glomerulosclerosis 4, susceptibility to
- APOL1 p.His298Arg Uncertain significance Multiple submitters
-
APOL1 p.Leu266Arg
Uncertain significance
Multiple submitters
focal segmental glomerulosclerosis 4, susceptibility to
- APOL1 p.Ala160Thr Uncertain significance Single submitter
- APOL1 p.Ala30Gly Uncertain significance Single submitter
- APOL1 p.Ala394Val Uncertain significance Single submitter
- APOL1 p.Ala56Val Uncertain significance Single submitter
- APOL1 p.Arg105Ser Uncertain significance Single submitter
- APOL1 p.Arg112His Uncertain significance Single submitter
- APOL1 p.Arg120Lys Uncertain significance Single submitter
- APOL1 p.Arg120Thr Uncertain significance Single submitter
- APOL1 p.Arg277Gly Uncertain significance Single submitter
- APOL1 p.Arg303His Uncertain significance Single submitter
- APOL1 p.Arg305Gln Uncertain significance Single submitter
- APOL1 p.Arg8Lys Uncertain significance Single submitter
- APOL1 p.Asn261Thr Uncertain significance Single submitter
- APOL1 p.Asn386Ser Uncertain significance Single submitter
- APOL1 p.Asn91Ile Uncertain significance Single submitter
- APOL1 p.Asp131Ala Uncertain significance Single submitter
- APOL1 p.Asp153Gly Uncertain significance Single submitter
- APOL1 p.Asp242Asn Uncertain significance Single submitter
- APOL1 p.Gln35Lys Uncertain significance Single submitter
- APOL1 p.Glu110Asp Uncertain significance Single submitter
- APOL1 p.Glu260Lys Uncertain significance Single submitter
- APOL1 p.Gly133Ser Uncertain significance Single submitter
- APOL1 p.Gly231Arg Uncertain significance Single submitter
- APOL1 p.Gly315Ser Uncertain significance Single submitter
- APOL1 p.Gly332Val Uncertain significance Single submitter
- APOL1 p.Gly53Ser Uncertain significance Single submitter
- APOL1 p.Gly58Asp Uncertain significance Single submitter
- APOL1 p.Ile123Asn Uncertain significance Single submitter
- APOL1 p.Ile216Thr Uncertain significance Single submitter
- APOL1 p.Ile223Val Uncertain significance Single submitter
-
APOL1 p.Ile245Val
Uncertain significance
Single submitter
focal segmental glomerulosclerosis 4, susceptibility to
- APOL1 p.Ile391Ser Uncertain significance Single submitter
- APOL1 p.Leu335Val Uncertain significance Single submitter
- APOL1 p.Leu7Val Uncertain significance Single submitter
- APOL1 p.Lys170Arg Uncertain significance Single submitter
- APOL1 p.Lys233Arg Uncertain significance Single submitter
- APOL1 p.Met124Thr Uncertain significance Single submitter
- APOL1 p.Met16Ile Uncertain significance Single submitter
- APOL1 p.Pro297Leu Uncertain significance Single submitter
- APOL1 p.Ser302Leu Uncertain significance Single submitter
- APOL1 p.Ser330Gly Uncertain significance Single submitter
- APOL1 p.Ser342Thr Uncertain significance Single submitter
-
APOL1 p.Val350Ile
Uncertain significance
Single submitter
focal segmental glomerulosclerosis 4, susceptibility to
- APOL1 p.Val38Ile Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
-
APOL1 p.Arg112Cys
Uncertain significance
Multiple submitters
focal segmental glomerulosclerosis 4, susceptibility to
- APOL1 p.Arg284His Benign/Likely benign Multiple submitters
-
APOL1 p.Ile384Phe
Uncertain significance
Multiple submitters
focal segmental glomerulosclerosis 4, susceptibility to
- APOL1 p.Leu158Phe Benign Multiple submitters
-
APOL1 p.Leu286Val
Uncertain significance
Multiple submitters
focal segmental glomerulosclerosis 4, susceptibility to
- APOL1 p.Leu385Phe Uncertain significance Multiple submitters
-
APOL1 p.Tyr351His
Uncertain significance
Multiple submitters
focal segmental glomerulosclerosis 4, susceptibility to
- APOL1 p.Ala197Ser Uncertain significance Single submitter
- APOL1 p.Ala219Thr Uncertain significance Single submitter
- APOL1 p.Ala368Thr Uncertain significance Single submitter
- APOL1 p.Arg146Leu Uncertain significance Single submitter
- APOL1 p.Arg159Cys Uncertain significance Single submitter
- APOL1 p.Arg303Cys Uncertain significance Single submitter
- APOL1 p.Asn154Tyr Uncertain significance Single submitter
- APOL1 p.Asp61Asn Uncertain significance Single submitter
- APOL1 p.Glu107Val Uncertain significance Single submitter
- APOL1 p.Glu355Lys Uncertain significance Single submitter
- APOL1 p.Glu366Asp Uncertain significance Single submitter
- APOL1 p.Glu370Val Uncertain significance Single submitter
- APOL1 p.Gly193Ser Uncertain significance Single submitter
- APOL1 p.Ile174Val Uncertain significance Single submitter
- APOL1 p.Ile279Ser Uncertain significance Single submitter
- APOL1 p.Leu21Phe Uncertain significance Single submitter
- APOL1 p.Leu392Arg Uncertain significance Single submitter
- APOL1 p.Met228Arg Likely benign Single submitter
- APOL1 p.Phe343Cys Uncertain significance Single submitter
- APOL1 p.Phe97Ser Uncertain significance Single submitter
- APOL1 p.Ser10Phe Uncertain significance Single submitter
- APOL1 p.Ser40Ile Uncertain significance Single submitter
- APOL1 p.Thr190Asn Uncertain significance Single submitter
- APOL1 p.Thr217Arg Uncertain significance Single submitter
-
APOL1 p.Thr217Pro
Uncertain significance
Single submitter
focal segmental glomerulosclerosis 4, susceptibility to
- APOL1 p.Thr221Ser Uncertain significance Single submitter
- APOL1 p.Thr89Ile Uncertain significance Single submitter
- APOL1 p.Trp139Cys Uncertain significance Single submitter
- APOL1 p.Val177Leu Uncertain significance Single submitter
- APOL1 p.Val192Ile Uncertain significance Single submitter
- APOL1 p.Val353Glu Benign Single submitter
All APOL1 variants
Conflicting classifications of pathogenicity 4
- p.Ala240Val Single submitter ⚠
- p.Leu266Ile Single submitter ⚠
- p.Lys334Arg Single submitter ⚠
- p.Lys390Glu Single submitter ⚠
Benign 39
- c.188-168A>G Multiple submitters
- c.188-210G>C Multiple submitters
- c.188-46A>G Multiple submitters
- c.314+21T>C Multiple submitters
- c.315-45G>A Multiple submitters
- c.315-48A>G Multiple submitters
- c.44+186T>G Multiple submitters
- c.99-90G>A Multiple submitters
- c.-19-27G>A Multiple submitters
- c.-20+526G>A Multiple submitters
- c.-20+537C>T Multiple submitters
- c.-20+701C>T Multiple submitters
- c.*151G>A Multiple submitters
- c.*292T>G Multiple submitters
- c.*298T>C Multiple submitters
- c.*307T>C Multiple submitters
- p.Ala218= Multiple submitters
- p.Arg255Lys Multiple submitters
- p.Arg320= Multiple submitters
- p.Asn176Ser Multiple submitters
- p.Asp337Asn Multiple submitters
- p.Glu150Lys Multiple submitters
- p.Gly96Arg Multiple submitters
- p.Leu158Phe Multiple submitters ⚠
- p.Met228Ile Multiple submitters
- c.187+290G>A Single submitter
- c.187+300_187+302del Single submitter
- c.188-313T>C Single submitter
- c.315-136A>G Single submitter
- c.315-222A>G Single submitter
- c.315-276C>T Single submitter
- c.45-198C>T Single submitter
- c.45-240G>T Single submitter
- c.-20+309G>A Single submitter
- c.*92T>A Single submitter
- p.Arg303= Single submitter
- p.Glu143fs Single submitter
- p.Glu256Gly Single submitter
- p.Val353Glu Single submitter ⚠
Benign/Likely benign 9
- c.188-14T>A Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to
- c.188-14T>G Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to
- c.315-7T>C Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to
- c.-20+739C>T Multiple submitters
- p.Arg284His Multiple submitters ⚠
- p.Asn264Lys Multiple submitters
- p.Gly270Asp Multiple submitters
- p.Leu191= Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to
- p.Lys372= Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to
Likely benign 44
- c.188-168A>C Multiple submitters
- c.314+14G>T Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to
- c.-19-762C>G Multiple submitters
- c.-19-843A>G Multiple submitters
- p.Ala394= Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to
- p.Asn106= Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to
- p.Gly315= Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to
- p.His130= Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to
- p.Ile279= Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to
- c.45-92C>T Single submitter
- c.-19-171G>T Single submitter
- p.Ala160= Single submitter
- p.Ala339Val Single submitter
- p.Arg288= Single submitter
- p.Asn261= Single submitter
- p.Asn271= Single submitter
- p.Asn37= Single submitter
- p.Asn95= Single submitter
- p.Asp337Gly Single submitter
- p.Glu319= Single submitter
- p.Leu196= Single submitter
- p.Leu21= Single submitter
- p.Leu268= Single submitter
- p.Lys364= Single submitter
- p.Met212Leu Single submitter
- p.Met228Arg Single submitter ⚠
- p.Phe199Val Single submitter
- p.Phe97= Single submitter
- p.Pro297= Single submitter
- p.Ser181= Single submitter
- p.Ser311= Single submitter
- p.Ser65= Single submitter
- p.Thr172= Single submitter
- p.Thr221= Single submitter
- p.Thr224= Single submitter
- p.Thr336= Single submitter
- p.Val178= Single submitter
- p.Val34= Single submitter
- p.Val346Leu Single submitter
- c.315-9C>T No assertion criteria APOL1-related disorder
- c.-19-5T>C No assertion criteria APOL1-related disorder
- c.-20+771T>C No assertion criteria APOL1-related disorder
- p.Asn176= No assertion criteria APOL1-related disorder
- p.Lys334= No assertion criteria APOL1-related disorder
Uncertain significance 92
- p.Ala108Glu Multiple submitters ⚠
- p.Ala394Gly Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to ⚠
- p.Arg112Cys Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to ⚠
- p.Asp46Gly Multiple submitters ⚠
- p.Glu323Gln Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to ⚠
- p.His298Arg Multiple submitters ⚠
- p.Ile384Phe Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to ⚠
- p.Leu266Arg Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to ⚠
- p.Leu286Val Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to ⚠
- p.Leu385Phe Multiple submitters ⚠
- p.Tyr351His Multiple submitters focal segmental glomerulosclerosis 4, susceptibility to ⚠
- c.187+4G>A Single submitter
- c.98+5G>T Single submitter
- c.-20+773G>C Single submitter
- p.Ala114fs Single submitter
- p.Ala160Thr Single submitter ⚠
- p.Ala197Ser Single submitter ⚠
- p.Ala219Thr Single submitter ⚠
- p.Ala30Gly Single submitter ⚠
- p.Ala368Thr Single submitter ⚠
- p.Ala394Val Single submitter ⚠
- p.Ala56Val Single submitter ⚠
- p.Arg105Ser Single submitter ⚠
- p.Arg112His Single submitter ⚠
- p.Arg120Lys Single submitter ⚠
- p.Arg120Thr Single submitter ⚠
- p.Arg146Leu Single submitter ⚠
- p.Arg159Cys Single submitter ⚠
- p.Arg277Gly Single submitter ⚠
- p.Arg303Cys Single submitter ⚠
- p.Arg303His Single submitter ⚠
- p.Arg305Gln Single submitter ⚠
- p.Arg8Lys Single submitter ⚠
- p.Asn154Tyr Single submitter ⚠
- p.Asn261Thr Single submitter ⚠
- p.Asn386Ser Single submitter ⚠
- p.Asn91Ile Single submitter ⚠
- p.Asp131Ala Single submitter ⚠
- p.Asp153Gly Single submitter ⚠
- p.Asp242Asn Single submitter ⚠
- p.Asp61Asn Single submitter ⚠
- p.Gln35Lys Single submitter ⚠
- p.Gln396Ter Single submitter
- p.Glu107Val Single submitter ⚠
- p.Glu110Asp Single submitter ⚠
- p.Glu260Lys Single submitter ⚠
- p.Glu355Lys Single submitter ⚠
- p.Glu366Asp Single submitter ⚠
- p.Glu370Leu Single submitter
- p.Glu370Val Single submitter ⚠
- p.Gly133Ser Single submitter ⚠
- p.Gly193Ser Single submitter ⚠
- p.Gly231Arg Single submitter ⚠
- p.Gly315Ser Single submitter ⚠
- p.Gly332Val Single submitter ⚠
- p.Gly53Ser Single submitter ⚠
- p.Gly58Asp Single submitter ⚠
- p.Ile123Asn Single submitter ⚠
- p.Ile174Val Single submitter ⚠
- p.Ile216Thr Single submitter ⚠
- p.Ile223Val Single submitter ⚠
- p.Ile245Val Single submitter focal segmental glomerulosclerosis 4, susceptibility to ⚠
- p.Ile279Ser Single submitter ⚠
- p.Ile391Ser Single submitter ⚠
- p.Leu21Phe Single submitter ⚠
- p.Leu335Val Single submitter ⚠
- p.Leu392Arg Single submitter ⚠
- p.Leu7Val Single submitter ⚠
- p.Lys170Arg Single submitter ⚠
- p.Lys233Arg Single submitter ⚠
- p.Met124Thr Single submitter ⚠
- p.Met16Ile Single submitter ⚠
- p.Phe343Cys Single submitter ⚠
- p.Phe97Ser Single submitter ⚠
- p.Pro297Leu Single submitter ⚠
- p.Ser10Phe Single submitter ⚠
- p.Ser302Leu Single submitter ⚠
- p.Ser302Ter Single submitter
- p.Ser330Gly Single submitter ⚠
- p.Ser342Thr Single submitter ⚠
- p.Ser40Ile Single submitter ⚠
- p.Thr190Asn Single submitter ⚠
- p.Thr217Arg Single submitter ⚠
- p.Thr217Pro Single submitter focal segmental glomerulosclerosis 4, susceptibility to ⚠
- p.Thr221Ser Single submitter ⚠
- p.Thr89Ile Single submitter ⚠
- p.Trp139Cys Single submitter ⚠
- p.Val177Leu Single submitter ⚠
- p.Val192Ile Single submitter ⚠
- p.Val350Ile Single submitter focal segmental glomerulosclerosis 4, susceptibility to ⚠
- p.Val38Ile Single submitter ⚠
- c.315-1G>A No assertion criteria APOL1-related disorder