APOL3 — 77 ClinVar variants
All ClinVar germline APOL3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
6 Benign · 9 Likely benign · 62 Uncertain significance
Full APOL3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOL3 c.-112C>T Uncertain significance Single submitter
- APOL3 c.-118T>C Uncertain significance Single submitter
- APOL3 c.-123G>C Uncertain significance Single submitter
- APOL3 p.Ala103Glu Uncertain significance Single submitter
- APOL3 p.Ala103Thr Uncertain significance Single submitter
- APOL3 p.Ala11Pro Uncertain significance Single submitter
- APOL3 p.Ala11Thr Uncertain significance Single submitter
- APOL3 p.Ala142Gly Uncertain significance Single submitter
- APOL3 p.Ala147Val Uncertain significance Single submitter
- APOL3 p.Ala216Asp Uncertain significance Single submitter
- APOL3 p.Ala234Asp Uncertain significance Single submitter
- APOL3 p.Arg267Gln Uncertain significance Single submitter
- APOL3 p.Arg324Cys Uncertain significance Single submitter
- APOL3 p.Arg324Leu Uncertain significance Single submitter
- APOL3 p.Asp47His Uncertain significance Single submitter
- APOL3 p.Cys328Arg Uncertain significance Single submitter
- APOL3 p.Gln34Pro Uncertain significance Single submitter
- APOL3 p.Glu215Lys Uncertain significance Single submitter
- APOL3 p.Gly134Val Uncertain significance Single submitter
- APOL3 p.Gly6Val Uncertain significance Single submitter
- APOL3 p.His331Arg Uncertain significance Single submitter
- APOL3 p.Ile189Thr Uncertain significance Single submitter
- APOL3 p.Ile18Val Uncertain significance Single submitter
- APOL3 p.Ile202Phe Uncertain significance Single submitter
- APOL3 p.Ile255Met Uncertain significance Single submitter
- APOL3 p.Ile255Thr Uncertain significance Single submitter
- APOL3 p.Leu155Pro Uncertain significance Single submitter
- APOL3 p.Leu236Pro Uncertain significance Single submitter
- APOL3 p.Lys14Arg Uncertain significance Single submitter
- APOL3 p.Lys196Glu Uncertain significance Single submitter
- APOL3 p.Met199Thr Uncertain significance Single submitter
- APOL3 p.Ser20Asn Uncertain significance Single submitter
- APOL3 p.Thr174Ile Uncertain significance Single submitter
- APOL3 p.Thr254Met Uncertain significance Single submitter
- APOL3 p.Thr26Ala Uncertain significance Single submitter
- APOL3 p.Thr28Pro Uncertain significance Single submitter
- APOL3 p.Thr61Ile Uncertain significance Single submitter
- APOL3 p.Thr9Ile Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- APOL3 p.Thr149Ile Benign Multiple submitters
- APOL3 p.Ala157Gly Uncertain significance Single submitter
- APOL3 p.Ala158Val Uncertain significance Single submitter
- APOL3 p.Ala279Ser Uncertain significance Single submitter
- APOL3 p.Ala301Thr Uncertain significance Single submitter
- APOL3 p.Arg17Trp Uncertain significance Single submitter
- APOL3 p.Arg225His Uncertain significance Single submitter
- APOL3 p.Arg260Trp Uncertain significance Single submitter
- APOL3 p.Arg267Trp Uncertain significance Single submitter
- APOL3 p.Arg306Trp Uncertain significance Single submitter
- APOL3 p.Glu170Lys Uncertain significance Single submitter
- APOL3 p.Glu288Lys Uncertain significance Single submitter
- APOL3 p.Glu302Asp Uncertain significance Single submitter
- APOL3 p.Glu48Val Uncertain significance Single submitter
- APOL3 p.Gly154Glu Uncertain significance Single submitter
- APOL3 p.Gly163Glu Uncertain significance Single submitter
- APOL3 p.Gly295Arg Uncertain significance Single submitter
- APOL3 p.Ile115Val Uncertain significance Single submitter
- APOL3 p.Ile220Thr Uncertain significance Single submitter
- APOL3 p.Ser167Asn Uncertain significance Single submitter
- APOL3 p.Ser270Arg Uncertain significance Single submitter
- APOL3 p.Thr144Met Uncertain significance Single submitter
- APOL3 p.Tyr322Cys Uncertain significance Single submitter
- APOL3 p.Val286Glu Uncertain significance Single submitter
- APOL3 p.Val43Met Uncertain significance Single submitter
All APOL3 variants
Benign 6
- c.-100A>G Multiple submitters
- p.Ala157Thr Multiple submitters
- p.Ala64Val Multiple submitters
- p.Asn31Asp Multiple submitters
- p.Cys22= Multiple submitters
- p.Thr149Ile Multiple submitters ⚠
Likely benign 9
- p.Cys13Trp Multiple submitters
- p.Gly35Val Multiple submitters
- p.Ala101Val Single submitter
- p.Arg100His Single submitter
- p.Arg200His Single submitter
- p.Arg324His Single submitter
- p.Arg324Ser Single submitter
- p.Glu178Lys Single submitter
- p.Thr144= Single submitter
Uncertain significance 62
- c.-112C>T Single submitter ⚠
- c.-118T>C Single submitter ⚠
- c.-123G>C Single submitter ⚠
- p.Ala103Glu Single submitter ⚠
- p.Ala103Thr Single submitter ⚠
- p.Ala11Pro Single submitter ⚠
- p.Ala11Thr Single submitter ⚠
- p.Ala142Gly Single submitter ⚠
- p.Ala147Val Single submitter ⚠
- p.Ala157Gly Single submitter ⚠
- p.Ala158Val Single submitter ⚠
- p.Ala216Asp Single submitter ⚠
- p.Ala234Asp Single submitter ⚠
- p.Ala279Ser Single submitter ⚠
- p.Ala301Thr Single submitter ⚠
- p.Arg17Trp Single submitter ⚠
- p.Arg225His Single submitter ⚠
- p.Arg260Trp Single submitter ⚠
- p.Arg267Gln Single submitter ⚠
- p.Arg267Trp Single submitter ⚠
- p.Arg306Trp Single submitter ⚠
- p.Arg324Cys Single submitter ⚠
- p.Arg324Leu Single submitter ⚠
- p.Asp47His Single submitter ⚠
- p.Cys328Arg Single submitter ⚠
- p.Gln34Pro Single submitter ⚠
- p.Glu170Lys Single submitter ⚠
- p.Glu215Lys Single submitter ⚠
- p.Glu288Lys Single submitter ⚠
- p.Glu302Asp Single submitter ⚠
- p.Glu48Val Single submitter ⚠
- p.Gly134Val Single submitter ⚠
- p.Gly154Glu Single submitter ⚠
- p.Gly163Glu Single submitter ⚠
- p.Gly295Arg Single submitter ⚠
- p.Gly6Val Single submitter ⚠
- p.His331Arg Single submitter ⚠
- p.Ile115Val Single submitter ⚠
- p.Ile189Thr Single submitter ⚠
- p.Ile18Val Single submitter ⚠
- p.Ile202Phe Single submitter ⚠
- p.Ile220Thr Single submitter ⚠
- p.Ile255Met Single submitter ⚠
- p.Ile255Thr Single submitter ⚠
- p.Leu155Pro Single submitter ⚠
- p.Leu236Pro Single submitter ⚠
- p.Lys14Arg Single submitter ⚠
- p.Lys196Glu Single submitter ⚠
- p.Met199Thr Single submitter ⚠
- p.Ser167Asn Single submitter ⚠
- p.Ser20Asn Single submitter ⚠
- p.Ser270Arg Single submitter ⚠
- p.Thr144Met Single submitter ⚠
- p.Thr174Ile Single submitter ⚠
- p.Thr254Met Single submitter ⚠
- p.Thr26Ala Single submitter ⚠
- p.Thr28Pro Single submitter ⚠
- p.Thr61Ile Single submitter ⚠
- p.Thr9Ile Single submitter ⚠
- p.Tyr322Cys Single submitter ⚠
- p.Val286Glu Single submitter ⚠
- p.Val43Met Single submitter ⚠