APOL4 — 19 ClinVar variants
All ClinVar germline APOL4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
5 Likely benign · 14 Uncertain significance
Full APOL4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOL4 p.Ala5Gly Uncertain significance Single submitter
- APOL4 p.Ala5Pro Uncertain significance Single submitter
- APOL4 p.Arg31His Uncertain significance Single submitter
- APOL4 p.Gly24Glu Uncertain significance Single submitter
- APOL4 p.His17Arg Uncertain significance Single submitter
- APOL4 p.Lys30Arg Uncertain significance Single submitter
- APOL4 p.Lys42Met Uncertain significance Single submitter
- APOL4 p.Phe10Ser Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- APOL4 p.Asp301Glu Uncertain significance Single submitter
- APOL4 p.Gln27His Likely benign Single submitter
- APOL4 p.Ile14Asn Uncertain significance Single submitter
- APOL4 p.Tyr77Cys Uncertain significance Single submitter
- APOL4 p.Val44Ile Uncertain significance Single submitter
- APOL4 p.Val44Leu Uncertain significance Single submitter
All APOL4 variants
Likely benign 5
- p.Ala182Ser Single submitter
- p.Gln27His Single submitter ⚠
- p.Lys8Arg Single submitter
- p.Phe109fs Single submitter
- p.Val13Met Single submitter
Uncertain significance 14
- c.-3G>A Single submitter
- p.Ala5Gly Single submitter ⚠
- p.Ala5Pro Single submitter ⚠
- p.Arg31His Single submitter ⚠
- p.Asp301Glu Single submitter ⚠
- p.Gly24Glu Single submitter ⚠
- p.His17Arg Single submitter ⚠
- p.Ile14Asn Single submitter ⚠
- p.Lys30Arg Single submitter ⚠
- p.Lys42Met Single submitter ⚠
- p.Phe10Ser Single submitter ⚠
- p.Tyr77Cys Single submitter ⚠
- p.Val44Ile Single submitter ⚠
- p.Val44Leu Single submitter ⚠