APOL5 — 77 ClinVar variants
All ClinVar germline APOL5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
2 Benign · 6 Likely benign · 69 Uncertain significance
Full APOL5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOL5 p.Ala197Ser Uncertain significance Single submitter
- APOL5 p.Ala226Thr Uncertain significance Single submitter
- APOL5 p.Arg193Lys Uncertain significance Single submitter
- APOL5 p.Arg204Gln Uncertain significance Single submitter
- APOL5 p.Arg30Gln Uncertain significance Single submitter
- APOL5 p.Arg367Gln Uncertain significance Single submitter
- APOL5 p.Arg367Gly Uncertain significance Single submitter
- APOL5 p.Arg432Gln Uncertain significance Single submitter
- APOL5 p.Arg84Gln Uncertain significance Single submitter
- APOL5 p.Asn219His Uncertain significance Single submitter
- APOL5 p.Asn219Lys Uncertain significance Single submitter
- APOL5 p.Asn261Asp Uncertain significance Single submitter
- APOL5 p.Asp88Ala Uncertain significance Single submitter
- APOL5 p.Asp92Glu Uncertain significance Single submitter
- APOL5 p.Asp92Gly Uncertain significance Single submitter
- APOL5 p.Glu114Gln Uncertain significance Single submitter
- APOL5 p.Glu213Gly Uncertain significance Single submitter
- APOL5 p.Glu281Gly Uncertain significance Single submitter
- APOL5 p.Glu327Gln Uncertain significance Single submitter
- APOL5 p.Gly13Asp Uncertain significance Single submitter
- APOL5 p.Gly165Val Uncertain significance Single submitter
- APOL5 p.Gly216Arg Uncertain significance Single submitter
- APOL5 p.Gly227Ala Uncertain significance Single submitter
- APOL5 p.Gly239Ala Uncertain significance Single submitter
- APOL5 p.Gly35Arg Uncertain significance Single submitter
- APOL5 p.Gly368Val Uncertain significance Single submitter
- APOL5 p.Gly36Cys Uncertain significance Single submitter
- APOL5 p.Gly40Arg Uncertain significance Single submitter
- APOL5 p.Gly412Asp Uncertain significance Single submitter
- APOL5 p.Gly4Ala Uncertain significance Single submitter
- APOL5 p.Gly4Cys Uncertain significance Single submitter
- APOL5 p.Gly72Val Uncertain significance Single submitter
- APOL5 p.Ile237Thr Uncertain significance Single submitter
- APOL5 p.Ile240Leu Uncertain significance Single submitter
- APOL5 p.Leu134Phe Uncertain significance Single submitter
- APOL5 p.Leu78Val Uncertain significance Single submitter
- APOL5 p.Lys41Arg Uncertain significance Single submitter
- APOL5 p.Lys41Met Uncertain significance Single submitter
- APOL5 p.Met168Ile Uncertain significance Single submitter
- APOL5 p.Met258Leu Uncertain significance Single submitter
- APOL5 p.Met287Thr Uncertain significance Single submitter
- APOL5 p.Met294Val Uncertain significance Single submitter
- APOL5 p.Met307Ile Uncertain significance Single submitter
- APOL5 p.Met90Thr Uncertain significance Single submitter
- APOL5 p.Phe77Leu Uncertain significance Single submitter
- APOL5 p.Pro351Gln Uncertain significance Single submitter
- APOL5 p.Pro382Ser Uncertain significance Single submitter
- APOL5 p.Pro384Leu Uncertain significance Single submitter
- APOL5 p.Pro401Thr Uncertain significance Single submitter
- APOL5 p.Pro418Gln Uncertain significance Single submitter
- APOL5 p.Pro428Leu Uncertain significance Single submitter
- APOL5 p.Pro91Ser Uncertain significance Single submitter
- APOL5 p.Trp292Cys Uncertain significance Single submitter
- APOL5 p.Trp383Arg Uncertain significance Single submitter
- APOL5 p.Trp383Cys Uncertain significance Single submitter
- APOL5 p.Val371Gly Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- APOL5 p.Ala124Glu Uncertain significance Single submitter
- APOL5 p.Ala141Asp Uncertain significance Single submitter
- APOL5 p.Ala146Asp Uncertain significance Single submitter
- APOL5 p.Ala163Glu Uncertain significance Single submitter
- APOL5 p.Ala198Gly Uncertain significance Single submitter
- APOL5 p.Ala333Pro Uncertain significance Single submitter
- APOL5 p.Arg199Ile Uncertain significance Single submitter
- APOL5 p.Arg370Cys Uncertain significance Single submitter
- APOL5 p.Gly145Arg Uncertain significance Single submitter
- APOL5 p.Leu176Phe Uncertain significance Single submitter
- APOL5 p.Phe102Cys Uncertain significance Single submitter
- APOL5 p.Thr325Ile Uncertain significance Single submitter
- APOL5 p.Val385Ile Uncertain significance Single submitter
All APOL5 variants
Benign 2
- p.Glu81Lys Multiple submitters
- p.Pro417fs Single submitter
Likely benign 6
- p.Arg425Gly Single submitter
- p.Glu132Lys Single submitter
- p.Gly72Asp Single submitter
- p.Lys402Glu Single submitter
- p.Thr122Ile Single submitter
- p.Thr65Ala Single submitter
Uncertain significance 69
- p.Ala124Glu Single submitter ⚠
- p.Ala141Asp Single submitter ⚠
- p.Ala146Asp Single submitter ⚠
- p.Ala163Glu Single submitter ⚠
- p.Ala197Ser Single submitter ⚠
- p.Ala198Gly Single submitter ⚠
- p.Ala226Thr Single submitter ⚠
- p.Ala333Pro Single submitter ⚠
- p.Arg193Lys Single submitter ⚠
- p.Arg199Ile Single submitter ⚠
- p.Arg204Gln Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg367Gln Single submitter ⚠
- p.Arg367Gly Single submitter ⚠
- p.Arg370Cys Single submitter ⚠
- p.Arg432Gln Single submitter ⚠
- p.Arg84Gln Single submitter ⚠
- p.Asn219His Single submitter ⚠
- p.Asn219Lys Single submitter ⚠
- p.Asn261Asp Single submitter ⚠
- p.Asp88Ala Single submitter ⚠
- p.Asp92Glu Single submitter ⚠
- p.Asp92Gly Single submitter ⚠
- p.Glu114Gln Single submitter ⚠
- p.Glu213Gly Single submitter ⚠
- p.Glu281Gly Single submitter ⚠
- p.Glu327Gln Single submitter ⚠
- p.Gly13Asp Single submitter ⚠
- p.Gly145Arg Single submitter ⚠
- p.Gly165Val Single submitter ⚠
- p.Gly216Arg Single submitter ⚠
- p.Gly227Ala Single submitter ⚠
- p.Gly239Ala Single submitter ⚠
- p.Gly35Arg Single submitter ⚠
- p.Gly368Val Single submitter ⚠
- p.Gly36Cys Single submitter ⚠
- p.Gly40Arg Single submitter ⚠
- p.Gly412Asp Single submitter ⚠
- p.Gly4Ala Single submitter ⚠
- p.Gly4Cys Single submitter ⚠
- p.Gly72Val Single submitter ⚠
- p.Ile237Thr Single submitter ⚠
- p.Ile240Leu Single submitter ⚠
- p.Leu134Phe Single submitter ⚠
- p.Leu176Phe Single submitter ⚠
- p.Leu78Val Single submitter ⚠
- p.Lys41Arg Single submitter ⚠
- p.Lys41Met Single submitter ⚠
- p.Met168Ile Single submitter ⚠
- p.Met258Leu Single submitter ⚠
- p.Met287Thr Single submitter ⚠
- p.Met294Val Single submitter ⚠
- p.Met307Ile Single submitter ⚠
- p.Met90Thr Single submitter ⚠
- p.Phe102Cys Single submitter ⚠
- p.Phe77Leu Single submitter ⚠
- p.Pro351Gln Single submitter ⚠
- p.Pro382Ser Single submitter ⚠
- p.Pro384Leu Single submitter ⚠
- p.Pro401Thr Single submitter ⚠
- p.Pro418Gln Single submitter ⚠
- p.Pro428Leu Single submitter ⚠
- p.Pro91Ser Single submitter ⚠
- p.Thr325Ile Single submitter ⚠
- p.Trp292Cys Single submitter ⚠
- p.Trp383Arg Single submitter ⚠
- p.Trp383Cys Single submitter ⚠
- p.Val371Gly Single submitter ⚠
- p.Val385Ile Single submitter ⚠