APOL6 — 72 ClinVar variants
All ClinVar germline APOL6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
13 Likely benign · 59 Uncertain significance
Full APOL6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- APOL6 p.Ala161Val Uncertain significance Single submitter
- APOL6 p.Ala200Val Uncertain significance Single submitter
- APOL6 p.Ala300Ser Uncertain significance Single submitter
- APOL6 p.Ala5Val Uncertain significance Single submitter
- APOL6 p.Arg186His Uncertain significance Single submitter
- APOL6 p.Arg213Gln Uncertain significance Single submitter
- APOL6 p.Arg213Trp Uncertain significance Single submitter
- APOL6 p.Asn199His Uncertain significance Single submitter
- APOL6 p.Asp150Asn Uncertain significance Single submitter
- APOL6 p.Gln139Arg Uncertain significance Single submitter
- APOL6 p.Gln219Arg Uncertain significance Single submitter
- APOL6 p.Glu10Gly Uncertain significance Single submitter
- APOL6 p.Gly115Ala Uncertain significance Single submitter
- APOL6 p.Gly12Ser Uncertain significance Single submitter
- APOL6 p.Gly302Arg Uncertain significance Single submitter
- APOL6 p.Gly309Glu Uncertain significance Single submitter
- APOL6 p.Ile67Met Uncertain significance Single submitter
- APOL6 p.Ile67Val Uncertain significance Single submitter
- APOL6 p.Lys160Asn Uncertain significance Single submitter
- APOL6 p.Lys182Arg Uncertain significance Single submitter
- APOL6 p.Lys295Glu Uncertain significance Single submitter
- APOL6 p.Phe267Val Uncertain significance Single submitter
- APOL6 p.Thr177Asn Uncertain significance Single submitter
- APOL6 p.Thr206Ala Uncertain significance Single submitter
- APOL6 p.Tyr339Ser Uncertain significance Single submitter
- APOL6 p.Val122Ile Uncertain significance Single submitter
- APOL6 p.Val216Met Uncertain significance Single submitter
- APOL6 p.Val28Met Uncertain significance Single submitter
- APOL6 p.Val296Glu Uncertain significance Single submitter
- APOL6 p.Val80Ala Uncertain significance Single submitter
Predictors split 35
The independent predictors disagree with each other — read with care.
- APOL6 p.Ala112Thr Likely benign Single submitter
- APOL6 p.Ala142Val Likely benign Single submitter
- APOL6 p.Ala166Pro Uncertain significance Single submitter
- APOL6 p.Ala181Asp Uncertain significance Single submitter
- APOL6 p.Ala228Val Likely benign Single submitter
- APOL6 p.Ala263Thr Uncertain significance Single submitter
- APOL6 p.Ala275Asp Uncertain significance Single submitter
- APOL6 p.Ala97Asp Uncertain significance Single submitter
- APOL6 p.Ala99Val Uncertain significance Single submitter
- APOL6 p.Arg141Trp Uncertain significance Single submitter
- APOL6 p.Arg196Cys Uncertain significance Single submitter
- APOL6 p.Arg203His Uncertain significance Single submitter
- APOL6 p.Arg299Met Uncertain significance Single submitter
- APOL6 p.Asn3Tyr Uncertain significance Single submitter
- APOL6 p.Asn78Lys Uncertain significance Single submitter
- APOL6 p.Asp156Asn Uncertain significance Single submitter
- APOL6 p.Cys333Gly Uncertain significance Single submitter
- APOL6 p.Glu155Ala Uncertain significance Single submitter
- APOL6 p.Glu279Lys Uncertain significance Single submitter
- APOL6 p.Glu38Lys Likely benign Single submitter
- APOL6 p.Gly113Val Uncertain significance Single submitter
- APOL6 p.Gly237Arg Uncertain significance Single submitter
- APOL6 p.Leu197Val Uncertain significance Single submitter
- APOL6 p.Leu35Pro Uncertain significance Single submitter
- APOL6 p.Lys59Asn Uncertain significance Single submitter
- APOL6 p.Lys72Asn Uncertain significance Single submitter
- APOL6 p.Met229Ile Uncertain significance Single submitter
- APOL6 p.Met326Lys Uncertain significance Single submitter
- APOL6 p.Ser106Asn Uncertain significance Single submitter
- APOL6 p.Ser298Pro Uncertain significance Single submitter
- APOL6 p.Ser88Cys Uncertain significance Single submitter
- APOL6 p.Ser92Asn Uncertain significance Single submitter
- APOL6 p.Thr102Lys Uncertain significance Single submitter
- APOL6 p.Thr84Ile Likely benign Single submitter
- APOL6 p.Val235Leu Likely benign Single submitter
All APOL6 variants
Likely benign 13
- p.Ala112Thr Single submitter ⚠
- p.Ala142Val Single submitter ⚠
- p.Ala228Val Single submitter ⚠
- p.Ala268= Single submitter
- p.Arg132His Single submitter
- p.Arg234= Single submitter
- p.Glu38Lys Single submitter ⚠
- p.Gly33Arg Single submitter
- p.Ile125= Single submitter
- p.Met79Val Single submitter
- p.Thr84Ile Single submitter ⚠
- p.Val185Ile Single submitter
- p.Val235Leu Single submitter ⚠
Uncertain significance 59
- p.Ala161Val Single submitter ⚠
- p.Ala166Pro Single submitter ⚠
- p.Ala181Asp Single submitter ⚠
- p.Ala200Val Single submitter ⚠
- p.Ala263Thr Single submitter ⚠
- p.Ala275Asp Single submitter ⚠
- p.Ala300Ser Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Ala97Asp Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Arg141Trp Single submitter ⚠
- p.Arg186His Single submitter ⚠
- p.Arg196Cys Single submitter ⚠
- p.Arg203His Single submitter ⚠
- p.Arg213Gln Single submitter ⚠
- p.Arg213Trp Single submitter ⚠
- p.Arg299Met Single submitter ⚠
- p.Asn199His Single submitter ⚠
- p.Asn3Tyr Single submitter ⚠
- p.Asn78Lys Single submitter ⚠
- p.Asp150Asn Single submitter ⚠
- p.Asp156Asn Single submitter ⚠
- p.Cys333Gly Single submitter ⚠
- p.Gln139Arg Single submitter ⚠
- p.Gln219Arg Single submitter ⚠
- p.Glu10Gly Single submitter ⚠
- p.Glu155Ala Single submitter ⚠
- p.Glu279Lys Single submitter ⚠
- p.Gly113Val Single submitter ⚠
- p.Gly115Ala Single submitter ⚠
- p.Gly12Ser Single submitter ⚠
- p.Gly237Arg Single submitter ⚠
- p.Gly302Arg Single submitter ⚠
- p.Gly309Glu Single submitter ⚠
- p.Ile67Met Single submitter ⚠
- p.Ile67Val Single submitter ⚠
- p.Leu197Val Single submitter ⚠
- p.Leu35Pro Single submitter ⚠
- p.Lys160Asn Single submitter ⚠
- p.Lys182Arg Single submitter ⚠
- p.Lys295Glu Single submitter ⚠
- p.Lys59Asn Single submitter ⚠
- p.Lys72Asn Single submitter ⚠
- p.Met229Ile Single submitter ⚠
- p.Met326Lys Single submitter ⚠
- p.Phe267Val Single submitter ⚠
- p.Ser106Asn Single submitter ⚠
- p.Ser298Pro Single submitter ⚠
- p.Ser88Cys Single submitter ⚠
- p.Ser92Asn Single submitter ⚠
- p.Thr102Lys Single submitter ⚠
- p.Thr177Asn Single submitter ⚠
- p.Thr206Ala Single submitter ⚠
- p.Tyr339Ser Single submitter ⚠
- p.Val122Ile Single submitter ⚠
- p.Val216Met Single submitter ⚠
- p.Val28Met Single submitter ⚠
- p.Val296Glu Single submitter ⚠
- p.Val80Ala Single submitter ⚠