APOM — 13 ClinVar variants
All ClinVar germline APOM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
3 Likely benign · 10 Uncertain significance
Full APOM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 8
The independent predictors disagree with each other — read with care.
- APOM p.Asn135Ile Uncertain significance Single submitter
- APOM p.Glu155Lys Likely benign Single submitter
- APOM p.Gly140Arg Uncertain significance Single submitter
- APOM p.Leu104Pro Uncertain significance Single submitter
- APOM p.Met80Ile Uncertain significance Single submitter
- APOM p.Pro24Thr Uncertain significance Single submitter
- APOM p.Pro79Leu Uncertain significance Single submitter
- APOM p.Tyr141Asn Uncertain significance Single submitter
All APOM variants
Likely benign 3
- p.Glu155Lys Single submitter ⚠
- p.Leu94Phe Single submitter
- p.Lys171Arg Single submitter
Uncertain significance 10
- c.261_269+28del Single submitter
- p.Arg89Pro Single submitter ⚠
- p.Asn135Ile Single submitter ⚠
- p.Glu59Lys Single submitter ⚠
- p.Gly140Arg Single submitter ⚠
- p.Leu104Pro Single submitter ⚠
- p.Met80Ile Single submitter ⚠
- p.Pro24Thr Single submitter ⚠
- p.Pro79Leu Single submitter ⚠
- p.Tyr141Asn Single submitter ⚠