ARAF — 47 ClinVar variants
All ClinVar germline ARAF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
3 Benign · 3 Likely benign · 41 Uncertain significance
Full ARAF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARAF p.His191Tyr Uncertain significance Multiple submitters
- ARAF p.Ala110Val Uncertain significance Single submitter
- ARAF p.Ala261Val Uncertain significance Single submitter
- ARAF p.Ala48Pro Uncertain significance Single submitter
- ARAF p.Arg151Cys Uncertain significance Single submitter
- ARAF p.Arg166Ser Uncertain significance Single submitter
-
ARAF p.Arg400His
Uncertain significance
Single submitter
Lymphatic anomaly
- ARAF p.Arg411Gln Uncertain significance Single submitter
- ARAF p.Asn100Asp Uncertain significance Single submitter
- ARAF p.Asn150Ser Uncertain significance Single submitter
- ARAF p.Asp408Asn Uncertain significance Single submitter
- ARAF p.Cys59Phe Uncertain significance Single submitter
- ARAF p.Glu13Lys Uncertain significance Single submitter
- ARAF p.Glu280Asp Uncertain significance Single submitter
- ARAF p.His395Tyr Uncertain significance Single submitter
- ARAF p.Ile232Met Uncertain significance Single submitter
- ARAF p.Leu294Val Uncertain significance Single submitter
-
ARAF p.Leu312Val
Uncertain significance
Single submitter
ARAF-related disorder
- ARAF p.Met227Val Uncertain significance Single submitter
- ARAF p.Phe239Val Uncertain significance Single submitter
- ARAF p.Phe369Cys Uncertain significance Single submitter
- ARAF p.Pro200Arg Uncertain significance Single submitter
- ARAF p.Pro270Ala Uncertain significance Single submitter
- ARAF p.Pro376Leu Uncertain significance Single submitter
- ARAF p.Pro3Leu Uncertain significance Single submitter
- ARAF p.Ser162Pro Uncertain significance Single submitter
- ARAF p.Ser172Leu Uncertain significance Single submitter
- ARAF p.Ser262Ile Uncertain significance Single submitter
- ARAF p.Ser510Gly Uncertain significance Single submitter
- ARAF p.Thr181Asn Uncertain significance Single submitter
- ARAF p.Val333Ala Uncertain significance Single submitter
- ARAF p.Val605Leu Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All ARAF variants
Benign 3
- p.Ala334= Multiple submitters
- p.Leu471= Multiple submitters
- p.Glu578Asp Single submitter
Likely benign 3
- p.Ala285= Single submitter
- p.Pro187Ser Single submitter
- p.Tyr42= Single submitter
Uncertain significance 41
- p.His191Tyr Multiple submitters ⚠
- c.97-7C>T Single submitter
- p.Ala110Val Single submitter ⚠
- p.Ala261Val Single submitter ⚠
- p.Ala48Pro Single submitter ⚠
- p.Arg151Cys Single submitter ⚠
- p.Arg166Ser Single submitter ⚠
- p.Arg16Trp Single submitter ⚠
- p.Arg279Cys Single submitter
- p.Arg400His Single submitter Lymphatic anomaly ⚠
- p.Arg411Gln Single submitter ⚠
- p.Arg524Cys Single submitter
- p.Asn100Asp Single submitter ⚠
- p.Asn150Ser Single submitter ⚠
- p.Asn217Ser Single submitter
- p.Asp408Asn Single submitter ⚠
- p.Cys59Phe Single submitter ⚠
- p.Glu13Lys Single submitter ⚠
- p.Glu280Asp Single submitter ⚠
- p.His219Arg Single submitter ⚠
- p.His395Tyr Single submitter ⚠
- p.Ile232Met Single submitter ⚠
- p.Ile366Val Single submitter
- p.Leu294Val Single submitter ⚠
- p.Leu312Val Single submitter ARAF-related disorder ⚠
- p.Met1Thr Single submitter
- p.Met227Val Single submitter ⚠
- p.Met503Ile Single submitter ⚠
- p.Phe239Val Single submitter ⚠
- p.Phe369Cys Single submitter ⚠
- p.Pro200Arg Single submitter ⚠
- p.Pro270Ala Single submitter ⚠
- p.Pro376Leu Single submitter ⚠
- p.Pro3Leu Single submitter ⚠
- p.Ser162Pro Single submitter ⚠
- p.Ser172Leu Single submitter ⚠
- p.Ser262Ile Single submitter ⚠
- p.Ser510Gly Single submitter ⚠
- p.Thr181Asn Single submitter ⚠
- p.Val333Ala Single submitter ⚠
- p.Val605Leu Single submitter ⚠