ARAP2 — 270 ClinVar variants

All ClinVar germline ARAP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 257 flagged for review →

13 Likely benign · 257 Uncertain significance

Full ARAP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 257

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 160

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 160

Predictors split 97

The independent predictors disagree with each other — read with care.

All ARAP2 variants

Likely benign 13

p.Ala464= Single submitter
p.Arg1492Leu Single submitter
p.Asn108Ser Single submitter
p.Asn936Ser Single submitter
p.Asn949Ser Single submitter
p.Asp10Asn Single submitter
p.Glu315Gly Single submitter
p.Ile1159Val Single submitter
p.Met1071Val Single submitter
p.Thr1526Met Single submitter
p.Thr227Ala Single submitter
p.Val1474= Single submitter
p.Val446Ile Single submitter

Uncertain significance 257

p.Ala1241Thr Single submitter ⚠
p.Ala1261Thr Single submitter ⚠
p.Ala1261Val Single submitter ⚠
p.Ala1353Glu Single submitter ⚠
p.Ala1375Pro Single submitter ⚠
p.Ala1421Ser Single submitter ⚠
p.Ala1421Thr Single submitter ⚠
p.Ala1508Thr Single submitter ⚠
p.Ala432Thr Single submitter ⚠
p.Ala460Thr Single submitter ⚠
p.Ala479Val Single submitter ⚠
p.Ala531Thr Single submitter ⚠
p.Ala857Thr Single submitter ⚠
p.Ala999Val Single submitter ⚠
p.Arg1237Gln Single submitter ⚠
p.Arg1237Gly Single submitter ⚠
p.Arg1346Gln Single submitter ⚠
p.Arg1346Trp Single submitter ⚠
p.Arg1387His Single submitter ⚠
p.Arg1401Trp Single submitter ⚠
p.Arg1459Gln Single submitter ⚠
p.Arg1459Trp Single submitter ⚠
p.Arg1492His Single submitter ⚠
p.Arg1551Gly Single submitter ⚠
p.Arg1577Gly Single submitter ⚠
p.Arg1577Trp Single submitter ⚠
p.Arg1589Ser Single submitter ⚠
p.Arg1591Gln Single submitter ⚠
p.Arg1624Gly Single submitter ⚠
p.Arg1631Trp Single submitter ⚠
p.Arg1691Gly Single submitter ⚠
p.Arg269Gly Single submitter ⚠
p.Arg271Cys Single submitter ⚠
p.Arg271His Single submitter ⚠
p.Arg280Gln Single submitter ⚠
p.Arg342Ile Single submitter ⚠
p.Arg342Ser Single submitter ⚠
p.Arg349Gln Single submitter ⚠
p.Arg57His Single submitter ⚠
p.Arg597Lys Single submitter ⚠
p.Arg642Leu Single submitter ⚠
p.Arg738Gly Single submitter ⚠
p.Asn1116Tyr Single submitter ⚠
p.Asn1133Lys Single submitter ⚠
p.Asn1284His Single submitter ⚠
p.Asn1579Ser Single submitter ⚠
p.Asn175Ser Single submitter ⚠
p.Asn324Lys Single submitter ⚠
p.Asn371Asp Single submitter ⚠
p.Asn517Ile Single submitter ⚠
p.Asn571His Single submitter ⚠
p.Asn694Asp Single submitter ⚠
p.Asn694Ile Single submitter ⚠
p.Asn697Lys Single submitter ⚠
p.Asn79Asp Single submitter ⚠
p.Asp1217Gly Single submitter ⚠
p.Asp1218Gly Single submitter ⚠
p.Asp1359Asn Single submitter ⚠
p.Asp1540Glu Single submitter ⚠
p.Asp1672Asn Single submitter ⚠
p.Asp174Gly Single submitter ⚠
p.Asp37Gly Single submitter ⚠
p.Asp684Asn Single submitter ⚠
p.Asp780Asn Single submitter ⚠
p.Cys1253Ser Single submitter ⚠
p.Cys216Ser Single submitter ⚠
p.Gln100Arg Single submitter ⚠
p.Gln100Pro Single submitter ⚠
p.Gln1020Glu Single submitter ⚠
p.Gln1049Arg Single submitter ⚠
p.Gln1073Leu Single submitter ⚠
p.Gln1119Pro Single submitter ⚠
p.Gln1122His Single submitter ⚠
p.Gln1698Lys Single submitter ⚠
p.Gln1701His Single submitter ⚠
p.Gln646Arg Single submitter ⚠
p.Gln726His Single submitter ⚠
p.Gln876Pro Single submitter ⚠
p.Glu1065Ala Single submitter ⚠
p.Glu1183Lys Single submitter ⚠
p.Glu1220Lys Single submitter ⚠
p.Glu1287Asp Single submitter ⚠
p.Glu1295Lys Single submitter ⚠
p.Glu204Ala Single submitter ⚠
p.Glu326Asp Single submitter ⚠
p.Glu344Gly Single submitter ⚠
p.Glu385Asp Single submitter ⚠
p.Glu414Gly Single submitter ⚠
p.Glu560Gly Single submitter ⚠
p.Glu662Asp Single submitter ⚠
p.Glu686Ala Single submitter ⚠
p.Glu776Gly Single submitter ⚠
p.Glu810Asp Single submitter ⚠
p.Glu882Lys Single submitter ⚠
p.Glu917Lys Single submitter ⚠
p.Glu950Gly Single submitter ⚠
p.Gly1075Trp Single submitter ⚠
p.Gly1087Arg Single submitter ⚠
p.Gly1326Arg Single submitter ⚠
p.Gly1466Glu Single submitter ⚠
p.Gly1646Val Single submitter ⚠
p.Gly235Arg Single submitter ⚠
p.Gly301Trp Single submitter ⚠
p.Gly364Arg Single submitter ⚠
p.Gly592Glu Single submitter ⚠
p.His1093Arg Single submitter ⚠
p.His1104Arg Single submitter ⚠
p.His1180Tyr Single submitter ⚠
p.His1513Arg Single submitter ⚠
p.His160Arg Single submitter ⚠
p.His286Tyr Single submitter ⚠
p.His877Asp Single submitter ⚠
p.His94Gln Single submitter ⚠
p.Ile104Thr Single submitter ⚠
p.Ile104Val Single submitter ⚠
p.Ile1196Thr Single submitter ⚠
p.Ile1363Met Single submitter ⚠
p.Ile1363Thr Single submitter ⚠
p.Ile1450Met Single submitter ⚠
p.Ile1559Met Single submitter ⚠
p.Ile178Thr Single submitter ⚠
p.Ile395Thr Single submitter ⚠
p.Ile41Val Single submitter ⚠
p.Ile470Met Single submitter ⚠
p.Ile470Val Single submitter ⚠
p.Ile512Val Single submitter ⚠
p.Ile51Met Single submitter ⚠
p.Ile526Val Single submitter ⚠
p.Ile568Leu Single submitter ⚠
p.Ile671Thr Single submitter ⚠
p.Ile76Met Single submitter ⚠
p.Ile952Phe Single submitter ⚠
p.Leu1017Met Single submitter ⚠
p.Leu1193Phe Single submitter ⚠
p.Leu1413Val Single submitter ⚠
p.Leu1590Val Single submitter ⚠
p.Leu1636Met Single submitter ⚠
p.Leu1645Val Single submitter ⚠
p.Leu201Met Single submitter ⚠
p.Leu236Phe Single submitter ⚠
p.Leu237Val Single submitter ⚠
p.Leu257Phe Single submitter ⚠
p.Leu425Ser Single submitter ⚠
p.Leu492Val Single submitter ⚠
p.Leu804Ser Single submitter ⚠
p.Leu812Phe Single submitter ⚠
p.Lys1167Arg Single submitter ⚠
p.Lys1168Thr Single submitter ⚠
p.Lys1392Arg Single submitter ⚠
p.Lys1547Gln Single submitter ⚠
p.Lys1622Glu Single submitter ⚠
p.Lys1649Gln Single submitter ⚠
p.Lys1659Asn Single submitter ⚠
p.Lys1695Glu Single submitter ⚠
p.Lys1704Arg Single submitter ⚠
p.Lys184Arg Single submitter ⚠
p.Lys376Thr Single submitter ⚠
p.Lys483Glu Single submitter ⚠
p.Lys502Asn Single submitter ⚠
p.Lys542Gln Single submitter ⚠
p.Lys602Glu Single submitter ⚠
p.Lys62Gln Single submitter ⚠
p.Lys761Arg Single submitter ⚠
p.Lys785Glu Single submitter ⚠
p.Lys91Glu Single submitter ⚠
p.Met1351Thr Single submitter ⚠
p.Met1529Val Single submitter ⚠
p.Met1611Thr Single submitter ⚠
p.Met252Ile Single submitter ⚠
p.Met632Thr Single submitter ⚠
p.Met632Val Single submitter ⚠
p.Met779Arg Single submitter ⚠
p.Met839Ile Single submitter ⚠
p.Met839Thr Single submitter ⚠
p.Met839Val Single submitter ⚠
p.Phe1022Leu Single submitter ⚠
p.Phe1022Val Single submitter ⚠
p.Phe500Val Single submitter ⚠
p.Phe543Leu Single submitter ⚠
p.Phe833Leu Single submitter ⚠
p.Phe894Leu Single submitter ⚠
p.Phe969Ser Single submitter ⚠
p.Pro118Leu Single submitter ⚠
p.Pro1233Ser Single submitter ⚠
p.Pro1339His Single submitter ⚠
p.Pro1368His Single submitter ⚠
p.Pro1500Ser Single submitter ⚠
p.Pro154Arg Single submitter ⚠
p.Pro154Ser Single submitter ⚠
p.Pro1648Ser Single submitter ⚠
p.Pro267Ser Single submitter ⚠
p.Pro452Leu Single submitter ⚠
p.Pro452Ser Single submitter ⚠
p.Pro53Leu Single submitter ⚠
p.Pro823Leu Single submitter ⚠
p.Pro850Arg Single submitter ⚠
p.Pro875Leu Single submitter ⚠
p.Ser1160Arg Single submitter ⚠
p.Ser1160Asn Single submitter ⚠
p.Ser1172Arg Single submitter ⚠
p.Ser1231Phe Single submitter ⚠
p.Ser1452Tyr Single submitter ⚠
p.Ser147Tyr Single submitter ⚠
p.Ser1677Thr Single submitter ⚠
p.Ser1690Leu Single submitter ⚠
p.Ser169Cys Single submitter ⚠
p.Ser173Ile Single submitter ⚠
p.Ser17Asn Single submitter ⚠
p.Ser270Gly Single submitter ⚠
p.Ser44Asn Single submitter ⚠
p.Ser608Asn Single submitter ⚠
p.Ser735Phe Single submitter ⚠
p.Ser748Asn Single submitter ⚠
p.Ser881Cys Single submitter ⚠
p.Ser932Gly Single submitter ⚠
p.Thr114Ile Single submitter ⚠
p.Thr1186Lys Single submitter ⚠
p.Thr1186Met Single submitter ⚠
p.Thr1275Met Single submitter ⚠
p.Thr1279Pro Single submitter ⚠
p.Thr1423Ala Single submitter ⚠
p.Thr1423Ile Single submitter ⚠
p.Thr227Ser Single submitter ⚠
p.Thr34Ala Single submitter ⚠
p.Thr547Ala Single submitter ⚠
p.Thr587Ile Single submitter ⚠
p.Thr643Ser Single submitter ⚠
p.Thr802Ser Single submitter ⚠
p.Trp747Arg Single submitter ⚠
p.Tyr1225Cys Single submitter ⚠
p.Tyr1248Cys Single submitter ⚠
p.Tyr1333Cys Single submitter ⚠
p.Tyr1471His Single submitter ⚠
p.Tyr258Cys Single submitter ⚠
p.Tyr334Cys Single submitter ⚠
p.Tyr515Cys Single submitter ⚠
p.Tyr599Cys Single submitter ⚠
p.Tyr654Phe Single submitter ⚠
p.Tyr685Cys Single submitter ⚠
p.Tyr900Asp Single submitter ⚠
p.Tyr934Cys Single submitter ⚠
p.Tyr962His Single submitter ⚠
p.Tyr974Cys Single submitter ⚠
p.Val1003Ile Single submitter ⚠
p.Val1080Ile Single submitter ⚠
p.Val1128Leu Single submitter ⚠
p.Val1128Phe Single submitter ⚠
p.Val1415Met Single submitter ⚠
p.Val1462Ala Single submitter ⚠
p.Val1601Met Single submitter ⚠
p.Val1612Leu Single submitter ⚠
p.Val1685Ala Single submitter ⚠
p.Val1685Glu Single submitter ⚠
p.Val535Leu Single submitter ⚠
p.Val556Ile Single submitter ⚠
p.Val634Ala Single submitter ⚠
p.Val884Ile Single submitter ⚠