AREG — 19 ClinVar variants
All ClinVar germline AREG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
1 Benign · 18 Uncertain significance
Full AREG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AREG p.Ala3Pro Uncertain significance Single submitter
- AREG p.Arg37His Uncertain significance Single submitter
- AREG p.Asn113Lys Uncertain significance Single submitter
- AREG p.Asp88Glu Uncertain significance Single submitter
- AREG p.Asp99Asn Uncertain significance Single submitter
- AREG p.Gln106Arg Uncertain significance Single submitter
- AREG p.Glu118Gln Uncertain significance Single submitter
- AREG p.Glu118Lys Uncertain significance Single submitter
- AREG p.Glu90Val Uncertain significance Single submitter
- AREG p.Gly157Arg Uncertain significance Single submitter
- AREG p.Pro110Leu Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- AREG p.Asp80Asn Uncertain significance Single submitter
- AREG p.Glu163Gln Uncertain significance Single submitter
- AREG p.Lys123Glu Uncertain significance Single submitter
- AREG p.Pro110His Uncertain significance Single submitter
- AREG p.Pro145Ser Uncertain significance Single submitter
- AREG p.Ser77Leu Uncertain significance Single submitter
- AREG p.Tyr33Cys Benign Single submitter
- AREG p.Val168Glu Uncertain significance Single submitter
All AREG variants
Benign 1
- p.Tyr33Cys Single submitter ⚠
Uncertain significance 18
- p.Ala3Pro Single submitter ⚠
- p.Arg37His Single submitter ⚠
- p.Asn113Lys Single submitter ⚠
- p.Asp80Asn Single submitter ⚠
- p.Asp88Glu Single submitter ⚠
- p.Asp99Asn Single submitter ⚠
- p.Gln106Arg Single submitter ⚠
- p.Glu118Gln Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Glu163Gln Single submitter ⚠
- p.Glu90Val Single submitter ⚠
- p.Gly157Arg Single submitter ⚠
- p.Lys123Glu Single submitter ⚠
- p.Pro110His Single submitter ⚠
- p.Pro110Leu Single submitter ⚠
- p.Pro145Ser Single submitter ⚠
- p.Ser77Leu Single submitter ⚠
- p.Val168Glu Single submitter ⚠