ARF4 — 8 ClinVar variants
All ClinVar germline ARF4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
8 Uncertain significance
Full ARF4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 6
The independent predictors disagree with each other — read with care.
- ARF4 p.Arg149Pro Uncertain significance Single submitter
- ARF4 p.Arg97His Uncertain significance Single submitter
- ARF4 p.Gly14Val Uncertain significance Single submitter
- ARF4 p.Ile61Val Uncertain significance Single submitter
- ARF4 p.Leu88Val Uncertain significance Single submitter
- ARF4 p.Lys16Arg Uncertain significance Single submitter
All ARF4 variants
Uncertain significance 8
- p.Arg149Pro Single submitter ⚠
- p.Arg97His Single submitter ⚠
- p.Arg97Ser Single submitter ⚠
- p.Gly14Val Single submitter ⚠
- p.Ile61Val Single submitter ⚠
- p.Leu88Val Single submitter ⚠
- p.Lys16Arg Single submitter ⚠
- p.Thr164Asn Single submitter ⚠