ARF5 — 12 ClinVar variants
All ClinVar germline ARF5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
1 Benign · 11 Uncertain significance
Full ARF5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 6
The independent predictors disagree with each other — read with care.
- ARF5 p.Arg149Cys Uncertain significance Single submitter
- ARF5 p.Arg180Cys Uncertain significance Single submitter
- ARF5 p.Asp114Asn Uncertain significance Single submitter
- ARF5 p.Glu138Gln Uncertain significance Single submitter
- ARF5 p.Met134Val Uncertain significance Single submitter
- ARF5 p.Ser137Arg Uncertain significance Single submitter
All ARF5 variants
Benign 1
- p.Thr164= Multiple submitters
Uncertain significance 11
- p.Arg149Cys Single submitter ⚠
- p.Arg151Cys Single submitter ⚠
- p.Arg180Cys Single submitter ⚠
- p.Arg97Trp Single submitter ⚠
- p.Asp114Asn Single submitter ⚠
- p.Glu138Gln Single submitter ⚠
- p.Leu116Pro Single submitter ⚠
- p.Met134Val Single submitter ⚠
- p.Phe51Tyr Single submitter ⚠
- p.Ser137Arg Single submitter ⚠
- p.Val120Gly Single submitter ⚠