ARFGAP1 — 78 ClinVar variants
All ClinVar germline ARFGAP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
9 Likely benign · 69 Uncertain significance
Full ARFGAP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARFGAP1 p.Ala108Thr Uncertain significance Single submitter
- ARFGAP1 p.Ala158Val Uncertain significance Single submitter
- ARFGAP1 p.Ala236Val Uncertain significance Single submitter
- ARFGAP1 p.Ala240Val Uncertain significance Single submitter
- ARFGAP1 p.Ala255Val Uncertain significance Single submitter
- ARFGAP1 p.Ala27Thr Uncertain significance Single submitter
- ARFGAP1 p.Ala352Thr Uncertain significance Single submitter
- ARFGAP1 p.Ala352Val Uncertain significance Single submitter
- ARFGAP1 p.Ala81Val Uncertain significance Single submitter
- ARFGAP1 p.Arg14Gly Uncertain significance Single submitter
- ARFGAP1 p.Arg182His Uncertain significance Single submitter
- ARFGAP1 p.Arg220Gln Uncertain significance Single submitter
- ARFGAP1 p.Arg220Trp Uncertain significance Single submitter
- ARFGAP1 p.Asn188Tyr Uncertain significance Single submitter
- ARFGAP1 p.Asn323Ser Uncertain significance Single submitter
- ARFGAP1 p.Asp266Asn Uncertain significance Single submitter
- ARFGAP1 p.Asp347Ala Uncertain significance Single submitter
- ARFGAP1 p.Asp347Asn Uncertain significance Single submitter
- ARFGAP1 p.Asp379Asn Uncertain significance Single submitter
- ARFGAP1 p.Asp398Ala Uncertain significance Single submitter
- ARFGAP1 p.Asp94Asn Uncertain significance Single submitter
- ARFGAP1 p.Glu12Ala Uncertain significance Single submitter
- ARFGAP1 p.Glu357Lys Uncertain significance Single submitter
- ARFGAP1 p.Gly187Arg Uncertain significance Single submitter
- ARFGAP1 p.Gly244Ser Uncertain significance Single submitter
- ARFGAP1 p.Gly26Ala Uncertain significance Single submitter
- ARFGAP1 p.Gly300Ser Uncertain significance Single submitter
- ARFGAP1 p.Gly315Ser Uncertain significance Single submitter
- ARFGAP1 p.Gly383Asp Uncertain significance Single submitter
- ARFGAP1 p.His245Arg Uncertain significance Single submitter
- ARFGAP1 p.Ile324Val Uncertain significance Single submitter
- ARFGAP1 p.Leu172Val Uncertain significance Single submitter
- ARFGAP1 p.Leu200Phe Uncertain significance Single submitter
- ARFGAP1 p.Leu56Pro Uncertain significance Single submitter
- ARFGAP1 p.Lys162Glu Uncertain significance Single submitter
- ARFGAP1 p.Lys260Glu Uncertain significance Single submitter
- ARFGAP1 p.Lys278Glu Uncertain significance Single submitter
- ARFGAP1 p.Phe186Ile Uncertain significance Single submitter
- ARFGAP1 p.Pro143Ser Uncertain significance Single submitter
- ARFGAP1 p.Pro191Leu Uncertain significance Single submitter
- ARFGAP1 p.Pro305Leu Uncertain significance Single submitter
- ARFGAP1 p.Pro305Ser Uncertain significance Single submitter
- ARFGAP1 p.Ser155Arg Uncertain significance Single submitter
- ARFGAP1 p.Ser159Ala Uncertain significance Single submitter
- ARFGAP1 p.Ser209Leu Uncertain significance Single submitter
- ARFGAP1 p.Ser270Asn Uncertain significance Single submitter
- ARFGAP1 p.Ser273Tyr Uncertain significance Single submitter
- ARFGAP1 p.Ser306Leu Uncertain significance Single submitter
- ARFGAP1 p.Ser360Ile Uncertain significance Single submitter
- ARFGAP1 p.Ser361Leu Uncertain significance Single submitter
- ARFGAP1 p.Thr141Lys Uncertain significance Single submitter
- ARFGAP1 p.Thr157Ile Uncertain significance Single submitter
- ARFGAP1 p.Thr189Met Uncertain significance Single submitter
- ARFGAP1 p.Val146Leu Uncertain significance Single submitter
- ARFGAP1 p.Val156Met Uncertain significance Single submitter
- ARFGAP1 p.Val290Ile Uncertain significance Single submitter
- ARFGAP1 p.Val9Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- ARFGAP1 p.Arg84Gln Uncertain significance Single submitter
- ARFGAP1 p.Asn29Ser Uncertain significance Single submitter
- ARFGAP1 p.Gln100Arg Uncertain significance Single submitter
- ARFGAP1 p.Glu123Val Uncertain significance Single submitter
- ARFGAP1 p.Gly262Glu Uncertain significance Single submitter
- ARFGAP1 p.Ser273Cys Uncertain significance Single submitter
- ARFGAP1 p.Ser277Phe Uncertain significance Single submitter
- ARFGAP1 p.Ser369Leu Uncertain significance Single submitter
- ARFGAP1 p.Trp134Arg Uncertain significance Single submitter
All ARFGAP1 variants
Likely benign 9
- c.835-300G>A Single submitter
- p.Arg341His Single submitter
- p.Asn405Asp Single submitter
- p.Gly177= Single submitter
- p.Gly368= Single submitter
- p.Gly384Arg Single submitter
- p.Ile70Val Single submitter
- p.Pro393Leu Single submitter
- p.Val391Ala Single submitter
Uncertain significance 69
- c.718-993C>T Single submitter
- p.Ala108Thr Single submitter ⚠
- p.Ala158Val Single submitter ⚠
- p.Ala236Val Single submitter ⚠
- p.Ala240Val Single submitter ⚠
- p.Ala255Val Single submitter ⚠
- p.Ala27Thr Single submitter ⚠
- p.Ala352Thr Single submitter ⚠
- p.Ala352Val Single submitter ⚠
- p.Ala81Val Single submitter ⚠
- p.Arg14Gly Single submitter ⚠
- p.Arg182His Single submitter ⚠
- p.Arg220Gln Single submitter ⚠
- p.Arg220Trp Single submitter ⚠
- p.Arg84Gln Single submitter ⚠
- p.Asn188Tyr Single submitter ⚠
- p.Asn29Ser Single submitter ⚠
- p.Asn323Ser Single submitter ⚠
- p.Asp266Asn Single submitter ⚠
- p.Asp347Ala Single submitter ⚠
- p.Asp347Asn Single submitter ⚠
- p.Asp379Asn Single submitter ⚠
- p.Asp398Ala Single submitter ⚠
- p.Asp94Asn Single submitter ⚠
- p.Gln100Arg Single submitter ⚠
- p.Glu123Val Single submitter ⚠
- p.Glu12Ala Single submitter ⚠
- p.Glu357Lys Single submitter ⚠
- p.Gly187Arg Single submitter ⚠
- p.Gly244Ser Single submitter ⚠
- p.Gly262Glu Single submitter ⚠
- p.Gly26Ala Single submitter ⚠
- p.Gly300Ser Single submitter ⚠
- p.Gly315Ser Single submitter ⚠
- p.Gly383Asp Single submitter ⚠
- p.His245Arg Single submitter ⚠
- p.Ile324Val Single submitter ⚠
- p.Leu172Val Single submitter ⚠
- p.Leu200Phe Single submitter ⚠
- p.Leu56Pro Single submitter ⚠
- p.Lys162Glu Single submitter ⚠
- p.Lys260Glu Single submitter ⚠
- p.Lys278Glu Single submitter ⚠
- p.Phe186Ile Single submitter ⚠
- p.Pro143Ser Single submitter ⚠
- p.Pro191Leu Single submitter ⚠
- p.Pro305Leu Single submitter ⚠
- p.Pro305Ser Single submitter ⚠
- p.Ser155Arg Single submitter ⚠
- p.Ser159Ala Single submitter ⚠
- p.Ser205Phe Single submitter
- p.Ser209Leu Single submitter ⚠
- p.Ser209Trp Single submitter
- p.Ser270Asn Single submitter ⚠
- p.Ser273Cys Single submitter ⚠
- p.Ser273Tyr Single submitter ⚠
- p.Ser277Phe Single submitter ⚠
- p.Ser306Leu Single submitter ⚠
- p.Ser360Ile Single submitter ⚠
- p.Ser361Leu Single submitter ⚠
- p.Ser369Leu Single submitter ⚠
- p.Thr141Lys Single submitter ⚠
- p.Thr157Ile Single submitter ⚠
- p.Thr189Met Single submitter ⚠
- p.Trp134Arg Single submitter ⚠
- p.Val146Leu Single submitter ⚠
- p.Val156Met Single submitter ⚠
- p.Val290Ile Single submitter ⚠
- p.Val9Ile Single submitter ⚠