ARFGAP3 — 84 ClinVar variants
All ClinVar germline ARFGAP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →
1 Benign · 4 Likely benign · 79 Uncertain significance
Full ARFGAP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 80
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARFGAP3 p.Ala164Val Uncertain significance Single submitter
- ARFGAP3 p.Ala170Glu Uncertain significance Single submitter
- ARFGAP3 p.Ala238Gly Uncertain significance Single submitter
- ARFGAP3 p.Ala262Thr Uncertain significance Single submitter
- ARFGAP3 p.Ala335Thr Uncertain significance Single submitter
- ARFGAP3 p.Ala426Ser Uncertain significance Single submitter
- ARFGAP3 p.Arg15Cys Uncertain significance Single submitter
- ARFGAP3 p.Arg403Pro Uncertain significance Single submitter
- ARFGAP3 p.Arg404Ser Uncertain significance Single submitter
- ARFGAP3 p.Arg466Lys Uncertain significance Single submitter
- ARFGAP3 p.Asn187Asp Uncertain significance Single submitter
- ARFGAP3 p.Asn219Lys Uncertain significance Single submitter
- ARFGAP3 p.Asn299His Uncertain significance Single submitter
- ARFGAP3 p.Asn299Ser Uncertain significance Single submitter
- ARFGAP3 p.Asn504Ser Uncertain significance Single submitter
- ARFGAP3 p.Asp27Gly Uncertain significance Single submitter
- ARFGAP3 p.Asp347Asn Uncertain significance Single submitter
- ARFGAP3 p.Glu359Lys Uncertain significance Single submitter
- ARFGAP3 p.Glu66Gly Uncertain significance Single submitter
- ARFGAP3 p.Gly82Arg Uncertain significance Single submitter
- ARFGAP3 p.Ile271Val Uncertain significance Single submitter
- ARFGAP3 p.Ile333Leu Uncertain significance Single submitter
- ARFGAP3 p.Ile510Val Uncertain significance Single submitter
- ARFGAP3 p.Leu208Ser Uncertain significance Single submitter
- ARFGAP3 p.Leu76Trp Uncertain significance Single submitter
- ARFGAP3 p.Lys31Glu Uncertain significance Single submitter
- ARFGAP3 p.Lys385Glu Uncertain significance Single submitter
- ARFGAP3 p.Lys420Thr Uncertain significance Single submitter
- ARFGAP3 p.Met286Ile Uncertain significance Single submitter
- ARFGAP3 p.Met79Ile Uncertain significance Single submitter
- ARFGAP3 p.Met79Thr Uncertain significance Single submitter
- ARFGAP3 p.Phe421Leu Uncertain significance Single submitter
- ARFGAP3 p.Phe43Ser Uncertain significance Single submitter
- ARFGAP3 p.Phe462Leu Uncertain significance Single submitter
- ARFGAP3 p.Pro332Arg Uncertain significance Single submitter
- ARFGAP3 p.Pro332Leu Uncertain significance Single submitter
- ARFGAP3 p.Pro332Ser Uncertain significance Single submitter
- ARFGAP3 p.Ser136Gly Uncertain significance Single submitter
- ARFGAP3 p.Ser136Thr Uncertain significance Single submitter
- ARFGAP3 p.Ser365Arg Uncertain significance Single submitter
- ARFGAP3 p.Ser458Leu Uncertain significance Single submitter
- ARFGAP3 p.Ser516Cys Uncertain significance Single submitter
- ARFGAP3 p.Ser88Ala Uncertain significance Single submitter
- ARFGAP3 p.Thr163Ala Uncertain significance Single submitter
- ARFGAP3 p.Thr176Ile Uncertain significance Single submitter
- ARFGAP3 p.Thr182Ser Uncertain significance Single submitter
- ARFGAP3 p.Thr21Ala Uncertain significance Single submitter
- ARFGAP3 p.Thr321Ile Uncertain significance Single submitter
- ARFGAP3 p.Thr401Ser Uncertain significance Single submitter
- ARFGAP3 p.Thr508Ser Uncertain significance Single submitter
- ARFGAP3 p.Tyr113Cys Uncertain significance Single submitter
- ARFGAP3 p.Tyr279Cys Uncertain significance Single submitter
- ARFGAP3 p.Tyr432Phe Uncertain significance Single submitter
- ARFGAP3 p.Val361Ala Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- ARFGAP3 p.Ala234Thr Uncertain significance Single submitter
- ARFGAP3 p.Arg15His Uncertain significance Single submitter
- ARFGAP3 p.Arg403His Uncertain significance Single submitter
- ARFGAP3 p.Arg404Cys Uncertain significance Single submitter
- ARFGAP3 p.Arg404Gly Uncertain significance Single submitter
- ARFGAP3 p.Arg446Cys Uncertain significance Single submitter
- ARFGAP3 p.Arg446His Uncertain significance Single submitter
- ARFGAP3 p.Arg513Gly Uncertain significance Single submitter
- ARFGAP3 p.Asp150Gly Uncertain significance Single submitter
- ARFGAP3 p.Asp376Val Uncertain significance Single submitter
- ARFGAP3 p.Asp484Asn Uncertain significance Single submitter
- ARFGAP3 p.Gln123Leu Uncertain significance Single submitter
- ARFGAP3 p.Gln248His Uncertain significance Single submitter
- ARFGAP3 p.Gln93Leu Uncertain significance Single submitter
- ARFGAP3 p.Gly230Glu Uncertain significance Single submitter
- ARFGAP3 p.Gly422Val Uncertain significance Single submitter
- ARFGAP3 p.His318Gln Uncertain significance Single submitter
- ARFGAP3 p.His94Tyr Uncertain significance Single submitter
- ARFGAP3 p.Ile327Arg Uncertain significance Single submitter
- ARFGAP3 p.Lys14Gln Uncertain significance Single submitter
- ARFGAP3 p.Met431Thr Benign Single submitter
- ARFGAP3 p.Ser173Tyr Uncertain significance Single submitter
- ARFGAP3 p.Ser457Asn Uncertain significance Single submitter
- ARFGAP3 p.Ser86Gly Uncertain significance Single submitter
- ARFGAP3 p.Val411Ala Uncertain significance Single submitter
- ARFGAP3 p.Val501Ile Uncertain significance Single submitter
All ARFGAP3 variants
Benign 1
- p.Met431Thr Single submitter ⚠
Likely benign 4
- p.Ala252Val Single submitter
- p.Asp289= Single submitter
- p.Val390Ile Single submitter
- p.Val507Met Single submitter
Uncertain significance 79
- p.Ala164Val Single submitter ⚠
- p.Ala170Glu Single submitter ⚠
- p.Ala234Thr Single submitter ⚠
- p.Ala238Gly Single submitter ⚠
- p.Ala262Thr Single submitter ⚠
- p.Ala335Thr Single submitter ⚠
- p.Ala426Ser Single submitter ⚠
- p.Arg15Cys Single submitter ⚠
- p.Arg15His Single submitter ⚠
- p.Arg403His Single submitter ⚠
- p.Arg403Pro Single submitter ⚠
- p.Arg404Cys Single submitter ⚠
- p.Arg404Gly Single submitter ⚠
- p.Arg404Ser Single submitter ⚠
- p.Arg446Cys Single submitter ⚠
- p.Arg446His Single submitter ⚠
- p.Arg466Lys Single submitter ⚠
- p.Arg513Gly Single submitter ⚠
- p.Asn187Asp Single submitter ⚠
- p.Asn219Lys Single submitter ⚠
- p.Asn299His Single submitter ⚠
- p.Asn299Ser Single submitter ⚠
- p.Asn504Ser Single submitter ⚠
- p.Asp150Gly Single submitter ⚠
- p.Asp27Gly Single submitter ⚠
- p.Asp347Asn Single submitter ⚠
- p.Asp376Val Single submitter ⚠
- p.Asp484Asn Single submitter ⚠
- p.Gln123Leu Single submitter ⚠
- p.Gln248His Single submitter ⚠
- p.Gln93Leu Single submitter ⚠
- p.Glu359Lys Single submitter ⚠
- p.Glu66Gly Single submitter ⚠
- p.Gly230Glu Single submitter ⚠
- p.Gly422Val Single submitter ⚠
- p.Gly82Arg Single submitter ⚠
- p.His318Gln Single submitter ⚠
- p.His94Tyr Single submitter ⚠
- p.Ile271Val Single submitter ⚠
- p.Ile327Arg Single submitter ⚠
- p.Ile333Leu Single submitter ⚠
- p.Ile510Val Single submitter ⚠
- p.Leu208Ser Single submitter ⚠
- p.Leu76Trp Single submitter ⚠
- p.Lys14Gln Single submitter ⚠
- p.Lys31Glu Single submitter ⚠
- p.Lys385Glu Single submitter ⚠
- p.Lys420Thr Single submitter ⚠
- p.Met286Ile Single submitter ⚠
- p.Met79Ile Single submitter ⚠
- p.Met79Thr Single submitter ⚠
- p.Phe421Leu Single submitter ⚠
- p.Phe43Ser Single submitter ⚠
- p.Phe462Leu Single submitter ⚠
- p.Pro332Arg Single submitter ⚠
- p.Pro332Leu Single submitter ⚠
- p.Pro332Ser Single submitter ⚠
- p.Ser136Gly Single submitter ⚠
- p.Ser136Thr Single submitter ⚠
- p.Ser173Tyr Single submitter ⚠
- p.Ser365Arg Single submitter ⚠
- p.Ser457Asn Single submitter ⚠
- p.Ser458Leu Single submitter ⚠
- p.Ser516Cys Single submitter ⚠
- p.Ser86Gly Single submitter ⚠
- p.Ser88Ala Single submitter ⚠
- p.Thr163Ala Single submitter ⚠
- p.Thr176Ile Single submitter ⚠
- p.Thr182Ser Single submitter ⚠
- p.Thr21Ala Single submitter ⚠
- p.Thr321Ile Single submitter ⚠
- p.Thr401Ser Single submitter ⚠
- p.Thr508Ser Single submitter ⚠
- p.Tyr113Cys Single submitter ⚠
- p.Tyr279Cys Single submitter ⚠
- p.Tyr432Phe Single submitter ⚠
- p.Val361Ala Single submitter ⚠
- p.Val411Ala Single submitter ⚠
- p.Val501Ile Single submitter ⚠