ARGFX — 40 ClinVar variants
All ClinVar germline ARGFX variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
5 Likely benign · 35 Uncertain significance
Full ARGFX gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARGFX p.Ala190Glu Uncertain significance Single submitter
- ARGFX p.Arg212Met Uncertain significance Single submitter
- ARGFX p.Arg82His Uncertain significance Single submitter
- ARGFX p.Asn188Ile Uncertain significance Single submitter
- ARGFX p.Asp238Tyr Uncertain significance Single submitter
- ARGFX p.Gln29Lys Uncertain significance Single submitter
- ARGFX p.Glu293Lys Uncertain significance Single submitter
- ARGFX p.Gly273Ser Uncertain significance Single submitter
- ARGFX p.His79Gln Uncertain significance Single submitter
- ARGFX p.Ile270Met Uncertain significance Single submitter
- ARGFX p.Leu111Pro Uncertain significance Single submitter
- ARGFX p.Leu149Phe Uncertain significance Single submitter
- ARGFX p.Leu233Met Uncertain significance Single submitter
- ARGFX p.Leu268Phe Uncertain significance Single submitter
- ARGFX p.Leu315Ile Uncertain significance Single submitter
- ARGFX p.Lys135Gln Uncertain significance Single submitter
- ARGFX p.Met101Val Uncertain significance Single submitter
- ARGFX p.Phe228Leu Uncertain significance Single submitter
- ARGFX p.Pro12Thr Uncertain significance Single submitter
- ARGFX p.Pro159Ser Uncertain significance Single submitter
- ARGFX p.Pro186Ser Uncertain significance Single submitter
- ARGFX p.Pro31Leu Uncertain significance Single submitter
- ARGFX p.Pro34Ser Uncertain significance Single submitter
- ARGFX p.Thr157Ile Uncertain significance Single submitter
- ARGFX p.Thr283Pro Uncertain significance Single submitter
- ARGFX p.Thr306Ile Uncertain significance Single submitter
- ARGFX p.Val261Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- ARGFX p.Arg114Thr Uncertain significance Single submitter
- ARGFX p.Arg129Gln Uncertain significance Single submitter
- ARGFX p.Arg129Trp Uncertain significance Single submitter
- ARGFX p.Arg130Gln Uncertain significance Single submitter
- ARGFX p.Gln138Arg Uncertain significance Single submitter
- ARGFX p.Glu109Gln Uncertain significance Single submitter
- ARGFX p.Ser164Asn Likely benign Single submitter
- ARGFX p.Ser177Arg Uncertain significance Single submitter
- ARGFX p.Ser279Tyr Uncertain significance Single submitter
All ARGFX variants
Likely benign 5
- p.Ala291Gly Single submitter
- p.Asp116Asn Single submitter
- p.Lys24Asn Single submitter
- p.Met23Ile Single submitter
- p.Ser164Asn Single submitter ⚠
Uncertain significance 35
- p.Ala190Glu Single submitter ⚠
- p.Arg114Thr Single submitter ⚠
- p.Arg129Gln Single submitter ⚠
- p.Arg129Trp Single submitter ⚠
- p.Arg130Gln Single submitter ⚠
- p.Arg212Met Single submitter ⚠
- p.Arg82His Single submitter ⚠
- p.Asn188Ile Single submitter ⚠
- p.Asp238Tyr Single submitter ⚠
- p.Gln138Arg Single submitter ⚠
- p.Gln29Lys Single submitter ⚠
- p.Glu109Gln Single submitter ⚠
- p.Glu293Lys Single submitter ⚠
- p.Gly273Ser Single submitter ⚠
- p.His79Gln Single submitter ⚠
- p.Ile270Met Single submitter ⚠
- p.Leu111Pro Single submitter ⚠
- p.Leu149Phe Single submitter ⚠
- p.Leu233Met Single submitter ⚠
- p.Leu268Phe Single submitter ⚠
- p.Leu315Ile Single submitter ⚠
- p.Lys135Gln Single submitter ⚠
- p.Met101Val Single submitter ⚠
- p.Phe228Leu Single submitter ⚠
- p.Pro12Thr Single submitter ⚠
- p.Pro159Ser Single submitter ⚠
- p.Pro186Ser Single submitter ⚠
- p.Pro31Leu Single submitter ⚠
- p.Pro34Ser Single submitter ⚠
- p.Ser177Arg Single submitter ⚠
- p.Ser279Tyr Single submitter ⚠
- p.Thr157Ile Single submitter ⚠
- p.Thr283Pro Single submitter ⚠
- p.Thr306Ile Single submitter ⚠
- p.Val261Ile Single submitter ⚠