ARHGAP1 — 56 ClinVar variants
All ClinVar germline ARHGAP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
1 Conflicting · 3 Benign · 5 Likely benign · 47 Uncertain significance
Full ARHGAP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP1 p.Ala225Ser Uncertain significance Single submitter
- ARHGAP1 p.Ala26Val Uncertain significance Single submitter
- ARHGAP1 p.Ala68Pro Uncertain significance Single submitter
- ARHGAP1 p.Arg234Gln Uncertain significance Single submitter
- ARHGAP1 p.Asp100Asn Uncertain significance Single submitter
- ARHGAP1 p.Asp132Asn Uncertain significance Single submitter
- ARHGAP1 p.Asp306Asn Uncertain significance Single submitter
- ARHGAP1 p.Gln384Glu Uncertain significance Single submitter
- ARHGAP1 p.Glu194Lys Uncertain significance Single submitter
- ARHGAP1 p.Glu362Lys Uncertain significance Single submitter
- ARHGAP1 p.Glu363Asp Uncertain significance Single submitter
- ARHGAP1 p.Gly397Arg Uncertain significance Single submitter
- ARHGAP1 p.His337Tyr Uncertain significance Single submitter
- ARHGAP1 p.Ile344Thr Uncertain significance Single submitter
- ARHGAP1 p.Ile378Thr Uncertain significance Single submitter
- ARHGAP1 p.Leu311Met Uncertain significance Single submitter
- ARHGAP1 p.Leu54Arg Uncertain significance Single submitter
- ARHGAP1 p.Lys31Glu Uncertain significance Single submitter
- ARHGAP1 p.Pro135Leu Uncertain significance Single submitter
- ARHGAP1 p.Pro176Ala Uncertain significance Single submitter
- ARHGAP1 p.Pro207Ser Uncertain significance Single submitter
- ARHGAP1 p.Pro235Leu Uncertain significance Single submitter
- ARHGAP1 p.Pro398Ser Uncertain significance Single submitter
- ARHGAP1 p.Pro3Leu Uncertain significance Single submitter
- ARHGAP1 p.Pro415Leu Uncertain significance Single submitter
- ARHGAP1 p.Pro434Leu Uncertain significance Single submitter
- ARHGAP1 p.Ser433Thr Uncertain significance Single submitter
- ARHGAP1 p.Thr420Ile Uncertain significance Single submitter
- ARHGAP1 p.Tyr188Cys Uncertain significance Single submitter
- ARHGAP1 p.Val73Ala Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- ARHGAP1 p.Ala373Thr Uncertain significance Single submitter
- ARHGAP1 p.Arg234Trp Uncertain significance Single submitter
- ARHGAP1 p.Arg349Trp Uncertain significance Single submitter
- ARHGAP1 p.Arg369Cys Likely benign Single submitter
- ARHGAP1 p.Arg369His Uncertain significance Single submitter
- ARHGAP1 p.Arg92Gln Uncertain significance Single submitter
- ARHGAP1 p.Asn253Ile Uncertain significance Single submitter
- ARHGAP1 p.Gln221His Uncertain significance Single submitter
- ARHGAP1 p.His381Arg Uncertain significance Single submitter
- ARHGAP1 p.Ile86Val Uncertain significance Single submitter
- ARHGAP1 p.Lys222Arg Uncertain significance Single submitter
- ARHGAP1 p.Phe370Ser Uncertain significance Single submitter
- ARHGAP1 p.Pro235His Uncertain significance Single submitter
- ARHGAP1 p.Pro254Thr Uncertain significance Single submitter
- ARHGAP1 p.Pro42Arg Uncertain significance Single submitter
- ARHGAP1 p.Pro95Leu Uncertain significance Single submitter
- ARHGAP1 p.Ser138Cys Uncertain significance Single submitter
- ARHGAP1 p.Thr266Ile Uncertain significance Single submitter
All ARHGAP1 variants
Conflicting classifications of pathogenicity 1
- p.Arg69Trp Single submitter ⚠
Benign 3
- p.Leu263Phe Multiple submitters
- p.Pro52= Multiple submitters
- p.Pro236= Single submitter
Likely benign 5
Uncertain significance 47
- p.Ala225Ser Single submitter ⚠
- p.Ala26Val Single submitter ⚠
- p.Ala373Thr Single submitter ⚠
- p.Ala68Pro Single submitter ⚠
- p.Arg234Gln Single submitter ⚠
- p.Arg234Trp Single submitter ⚠
- p.Arg349Trp Single submitter ⚠
- p.Arg369His Single submitter ⚠
- p.Arg92Gln Single submitter ⚠
- p.Asn253Ile Single submitter ⚠
- p.Asp100Asn Single submitter ⚠
- p.Asp132Asn Single submitter ⚠
- p.Asp306Asn Single submitter ⚠
- p.Gln221His Single submitter ⚠
- p.Gln384Glu Single submitter ⚠
- p.Glu194Lys Single submitter ⚠
- p.Glu362Lys Single submitter ⚠
- p.Glu363Asp Single submitter ⚠
- p.Gly397Arg Single submitter ⚠
- p.His337Tyr Single submitter ⚠
- p.His381Arg Single submitter ⚠
- p.Ile344Thr Single submitter ⚠
- p.Ile378Thr Single submitter ⚠
- p.Ile86Val Single submitter ⚠
- p.Leu311Met Single submitter ⚠
- p.Leu54Arg Single submitter ⚠
- p.Lys222Arg Single submitter ⚠
- p.Lys31Glu Single submitter ⚠
- p.Phe370Ser Single submitter ⚠
- p.Pro135Leu Single submitter ⚠
- p.Pro176Ala Single submitter ⚠
- p.Pro207Ser Single submitter ⚠
- p.Pro235His Single submitter ⚠
- p.Pro235Leu Single submitter ⚠
- p.Pro254Thr Single submitter ⚠
- p.Pro398Ser Single submitter ⚠
- p.Pro3Leu Single submitter ⚠
- p.Pro415Leu Single submitter ⚠
- p.Pro42Arg Single submitter ⚠
- p.Pro434Leu Single submitter ⚠
- p.Pro95Leu Single submitter ⚠
- p.Ser138Cys Single submitter ⚠
- p.Ser433Thr Single submitter ⚠
- p.Thr266Ile Single submitter ⚠
- p.Thr420Ile Single submitter ⚠
- p.Tyr188Cys Single submitter ⚠
- p.Val73Ala Single submitter ⚠