ARHGAP11B — 43 ClinVar variants
All ClinVar germline ARHGAP11B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
3 Likely benign · 40 Uncertain significance
Full ARHGAP11B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP11B p.Ala135Gly Uncertain significance Single submitter
- ARHGAP11B p.Ala164Thr Uncertain significance Single submitter
- ARHGAP11B p.Ala53Val Uncertain significance Single submitter
- ARHGAP11B p.Arg261Ser Uncertain significance Single submitter
- ARHGAP11B p.Arg27His Uncertain significance Single submitter
- ARHGAP11B p.Arg87Trp Uncertain significance Single submitter
- ARHGAP11B p.Asp103Glu Uncertain significance Single submitter
- ARHGAP11B p.Asp71Asn Uncertain significance Single submitter
- ARHGAP11B p.Gln13Arg Uncertain significance Single submitter
- ARHGAP11B p.Glu139Gly Uncertain significance Single submitter
- ARHGAP11B p.Glu151Lys Uncertain significance Single submitter
- ARHGAP11B p.Glu211Lys Uncertain significance Single submitter
- ARHGAP11B p.Glu36Gly Uncertain significance Single submitter
- ARHGAP11B p.Glu77Gly Uncertain significance Single submitter
- ARHGAP11B p.Glu78Asp Uncertain significance Single submitter
- ARHGAP11B p.Gly221Asp Uncertain significance Single submitter
- ARHGAP11B p.Gly90Glu Uncertain significance Single submitter
- ARHGAP11B p.His169Tyr Uncertain significance Single submitter
- ARHGAP11B p.Ile198Thr Uncertain significance Single submitter
- ARHGAP11B p.Ile260Thr Uncertain significance Single submitter
- ARHGAP11B p.Ile46Thr Uncertain significance Single submitter
- ARHGAP11B p.Leu257Val Uncertain significance Single submitter
- ARHGAP11B p.Lys229Arg Uncertain significance Single submitter
- ARHGAP11B p.Lys251Met Uncertain significance Single submitter
- ARHGAP11B p.Met190Thr Uncertain significance Single submitter
- ARHGAP11B p.Phe18Leu Uncertain significance Single submitter
- ARHGAP11B p.Pro55Leu Uncertain significance Single submitter
- ARHGAP11B p.Pro66Ser Uncertain significance Single submitter
- ARHGAP11B p.Ser186Arg Uncertain significance Single submitter
- ARHGAP11B p.Thr149Arg Uncertain significance Single submitter
- ARHGAP11B p.Thr37Ala Uncertain significance Single submitter
- ARHGAP11B p.Val170Leu Uncertain significance Single submitter
- ARHGAP11B p.Val222Glu Uncertain significance Single submitter
- ARHGAP11B p.Val23Leu Uncertain significance Single submitter
- ARHGAP11B p.Val241Leu Uncertain significance Single submitter
- ARHGAP11B p.Val258Ala Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All ARHGAP11B variants
Likely benign 3
- p.Ala58Val Single submitter
- p.Asn266Lys Single submitter
- p.Val222Met Single submitter
Uncertain significance 40
- p.Ala135Gly Single submitter ⚠
- p.Ala164Thr Single submitter ⚠
- p.Ala53Val Single submitter ⚠
- p.Arg261Ser Single submitter ⚠
- p.Arg27His Single submitter ⚠
- p.Arg87Trp Single submitter ⚠
- p.Asp103Glu Single submitter ⚠
- p.Asp103Val Single submitter ⚠
- p.Asp71Asn Single submitter ⚠
- p.Gln13Arg Single submitter ⚠
- p.Glu139Gly Single submitter ⚠
- p.Glu151Lys Single submitter ⚠
- p.Glu211Lys Single submitter ⚠
- p.Glu36Gly Single submitter ⚠
- p.Glu77Gly Single submitter ⚠
- p.Glu78Asp Single submitter ⚠
- p.Glu83Lys Single submitter
- p.Gly221Asp Single submitter ⚠
- p.Gly90Glu Single submitter ⚠
- p.His169Tyr Single submitter ⚠
- p.Ile198Thr Single submitter ⚠
- p.Ile260Thr Single submitter ⚠
- p.Ile46Thr Single submitter ⚠
- p.Leu109Pro Single submitter ⚠
- p.Leu257Val Single submitter ⚠
- p.Lys229Arg Single submitter ⚠
- p.Lys251Met Single submitter ⚠
- p.Met190Thr Single submitter ⚠
- p.Phe174Cys Single submitter
- p.Phe18Leu Single submitter ⚠
- p.Pro55Leu Single submitter ⚠
- p.Pro66Ser Single submitter ⚠
- p.Ser186Arg Single submitter ⚠
- p.Thr149Arg Single submitter ⚠
- p.Thr37Ala Single submitter ⚠
- p.Val170Leu Single submitter ⚠
- p.Val222Glu Single submitter ⚠
- p.Val23Leu Single submitter ⚠
- p.Val241Leu Single submitter ⚠
- p.Val258Ala Single submitter ⚠