ARHGAP17 — 108 ClinVar variants
All ClinVar germline ARHGAP17 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 103 flagged for review →
5 Likely benign · 103 Uncertain significance
Full ARHGAP17 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 103
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP17 p.Ala400Val Uncertain significance Single submitter
- ARHGAP17 p.Ala453Val Uncertain significance Single submitter
- ARHGAP17 p.Ala538Ser Uncertain significance Single submitter
- ARHGAP17 p.Ala538Thr Uncertain significance Single submitter
- ARHGAP17 p.Ala607Pro Uncertain significance Single submitter
- ARHGAP17 p.Ala622Val Uncertain significance Single submitter
- ARHGAP17 p.Ala710Thr Uncertain significance Single submitter
- ARHGAP17 p.Ala880Thr Uncertain significance Single submitter
- ARHGAP17 p.Arg238Gln Uncertain significance Single submitter
- ARHGAP17 p.Arg40Trp Uncertain significance Single submitter
- ARHGAP17 p.Arg49Cys Uncertain significance Single submitter
- ARHGAP17 p.Arg548Gly Uncertain significance Single submitter
- ARHGAP17 p.Arg673Gln Uncertain significance Single submitter
- ARHGAP17 p.Arg699Gln Uncertain significance Single submitter
- ARHGAP17 p.Arg849His Uncertain significance Single submitter
- ARHGAP17 p.Asn371His Uncertain significance Single submitter
- ARHGAP17 p.Asn470His Uncertain significance Single submitter
- ARHGAP17 p.Asn737Lys Uncertain significance Single submitter
- ARHGAP17 p.Asn783Ile Uncertain significance Single submitter
- ARHGAP17 p.Asn828Ile Uncertain significance Single submitter
- ARHGAP17 p.Asn828Ser Uncertain significance Single submitter
- ARHGAP17 p.Asp573Asn Uncertain significance Single submitter
- ARHGAP17 p.Gln545Glu Uncertain significance Single submitter
- ARHGAP17 p.Gln567Arg Uncertain significance Single submitter
- ARHGAP17 p.Gln567Glu Uncertain significance Single submitter
- ARHGAP17 p.Gln605His Uncertain significance Single submitter
- ARHGAP17 p.Glu444Asp Uncertain significance Single submitter
- ARHGAP17 p.Glu566Val Uncertain significance Single submitter
- ARHGAP17 p.Gly414Arg Uncertain significance Single submitter
- ARHGAP17 p.Gly469Ala Uncertain significance Single submitter
- ARHGAP17 p.Gly555Ser Uncertain significance Single submitter
- ARHGAP17 p.Gly600Val Uncertain significance Single submitter
- ARHGAP17 p.Gly687Ser Uncertain significance Single submitter
- ARHGAP17 p.His752Gln Uncertain significance Single submitter
- ARHGAP17 p.Ile379Phe Uncertain significance Single submitter
- ARHGAP17 p.Ile564Leu Uncertain significance Single submitter
- ARHGAP17 p.Ile708Val Uncertain significance Single submitter
- ARHGAP17 p.Leu407Phe Uncertain significance Single submitter
- ARHGAP17 p.Leu613His Uncertain significance Single submitter
- ARHGAP17 p.Leu779Pro Uncertain significance Single submitter
- ARHGAP17 p.Met419Lys Uncertain significance Single submitter
- ARHGAP17 p.Met485Val Uncertain significance Single submitter
- ARHGAP17 p.Met503Ile Uncertain significance Single submitter
- ARHGAP17 p.Met739Val Uncertain significance Single submitter
- ARHGAP17 p.Pro528Leu Uncertain significance Single submitter
- ARHGAP17 p.Pro537Ser Uncertain significance Single submitter
- ARHGAP17 p.Pro543Arg Uncertain significance Single submitter
- ARHGAP17 p.Pro569Leu Uncertain significance Single submitter
- ARHGAP17 p.Pro579Leu Uncertain significance Single submitter
- ARHGAP17 p.Pro663Ser Uncertain significance Single submitter
- ARHGAP17 p.Pro754Ser Uncertain significance Single submitter
- ARHGAP17 p.Pro755Ser Uncertain significance Single submitter
- ARHGAP17 p.Pro764Leu Uncertain significance Single submitter
- ARHGAP17 p.Pro797Gln Uncertain significance Single submitter
- ARHGAP17 p.Pro812Ala Uncertain significance Single submitter
- ARHGAP17 p.Pro865Ser Uncertain significance Single submitter
- ARHGAP17 p.Ser552Gly Uncertain significance Single submitter
- ARHGAP17 p.Ser657Leu Uncertain significance Single submitter
- ARHGAP17 p.Thr307Ala Uncertain significance Single submitter
- ARHGAP17 p.Thr838Ala Uncertain significance Single submitter
- ARHGAP17 p.Thr96Met Uncertain significance Single submitter
- ARHGAP17 p.Val320Ile Uncertain significance Single submitter
- ARHGAP17 p.Val587Leu Uncertain significance Single submitter
Predictors split 40
The independent predictors disagree with each other — read with care.
- ARHGAP17 p.Arg630His Uncertain significance Multiple submitters
- ARHGAP17 p.Ala142Thr Uncertain significance Single submitter
- ARHGAP17 p.Ala203Val Uncertain significance Single submitter
- ARHGAP17 p.Ala637Thr Uncertain significance Single submitter
- ARHGAP17 p.Ala880Val Uncertain significance Single submitter
- ARHGAP17 p.Arg481Trp Uncertain significance Single submitter
- ARHGAP17 p.Arg631Gly Uncertain significance Single submitter
- ARHGAP17 p.Arg867Cys Uncertain significance Single submitter
- ARHGAP17 p.Asn185Ser Uncertain significance Single submitter
- ARHGAP17 p.Asp439Asn Uncertain significance Single submitter
- ARHGAP17 p.Gln814Glu Uncertain significance Single submitter
- ARHGAP17 p.Gly280Ala Uncertain significance Single submitter
- ARHGAP17 p.His611Tyr Uncertain significance Single submitter
- ARHGAP17 p.Lys356Asn Uncertain significance Single submitter
- ARHGAP17 p.Lys480Asn Uncertain significance Single submitter
- ARHGAP17 p.Pro460Leu Uncertain significance Single submitter
- ARHGAP17 p.Pro525Leu Uncertain significance Single submitter
- ARHGAP17 p.Pro636His Uncertain significance Single submitter
- ARHGAP17 p.Pro638Leu Uncertain significance Single submitter
- ARHGAP17 p.Pro641Leu Uncertain significance Single submitter
- ARHGAP17 p.Pro668Arg Uncertain significance Single submitter
- ARHGAP17 p.Pro715Ser Uncertain significance Single submitter
- ARHGAP17 p.Pro795Leu Uncertain significance Single submitter
- ARHGAP17 p.Pro813Arg Uncertain significance Single submitter
- ARHGAP17 p.Pro813His Uncertain significance Single submitter
- ARHGAP17 p.Ser397Asn Uncertain significance Single submitter
- ARHGAP17 p.Ser474Pro Uncertain significance Single submitter
- ARHGAP17 p.Ser546Asn Uncertain significance Single submitter
- ARHGAP17 p.Ser547Cys Uncertain significance Single submitter
- ARHGAP17 p.Ser655Asn Uncertain significance Single submitter
- ARHGAP17 p.Ser772Arg Uncertain significance Single submitter
- ARHGAP17 p.Ser840Phe Uncertain significance Single submitter
- ARHGAP17 p.Thr38Met Uncertain significance Single submitter
- ARHGAP17 p.Thr530Ile Uncertain significance Single submitter
- ARHGAP17 p.Thr628Ile Uncertain significance Single submitter
- ARHGAP17 p.Thr679Ile Uncertain significance Single submitter
- ARHGAP17 p.Thr759Ala Uncertain significance Single submitter
- ARHGAP17 p.Val535Met Uncertain significance Single submitter
- ARHGAP17 p.Val536Met Uncertain significance Single submitter
- ARHGAP17 p.Val633Ile Uncertain significance Single submitter
All ARHGAP17 variants
Likely benign 5
- p.Ala400= Single submitter
- p.Arg867His Single submitter
- p.Asn594Ser Single submitter
- p.Asn712Ser Single submitter
- p.Ser349= Single submitter
Uncertain significance 103
- p.Arg630His Multiple submitters ⚠
- p.Ala142Thr Single submitter ⚠
- p.Ala203Val Single submitter ⚠
- p.Ala400Val Single submitter ⚠
- p.Ala453Val Single submitter ⚠
- p.Ala538Ser Single submitter ⚠
- p.Ala538Thr Single submitter ⚠
- p.Ala607Pro Single submitter ⚠
- p.Ala622Val Single submitter ⚠
- p.Ala637Thr Single submitter ⚠
- p.Ala710Thr Single submitter ⚠
- p.Ala880Thr Single submitter ⚠
- p.Ala880Val Single submitter ⚠
- p.Arg238Gln Single submitter ⚠
- p.Arg40Trp Single submitter ⚠
- p.Arg481Trp Single submitter ⚠
- p.Arg49Cys Single submitter ⚠
- p.Arg548Gly Single submitter ⚠
- p.Arg631Gly Single submitter ⚠
- p.Arg673Gln Single submitter ⚠
- p.Arg699Gln Single submitter ⚠
- p.Arg849His Single submitter ⚠
- p.Arg867Cys Single submitter ⚠
- p.Asn185Ser Single submitter ⚠
- p.Asn371His Single submitter ⚠
- p.Asn470His Single submitter ⚠
- p.Asn737Lys Single submitter ⚠
- p.Asn783Ile Single submitter ⚠
- p.Asn828Ile Single submitter ⚠
- p.Asn828Ser Single submitter ⚠
- p.Asp439Asn Single submitter ⚠
- p.Asp573Asn Single submitter ⚠
- p.Gln545Glu Single submitter ⚠
- p.Gln567Arg Single submitter ⚠
- p.Gln567Glu Single submitter ⚠
- p.Gln605His Single submitter ⚠
- p.Gln814Glu Single submitter ⚠
- p.Glu444Asp Single submitter ⚠
- p.Glu566Val Single submitter ⚠
- p.Gly280Ala Single submitter ⚠
- p.Gly414Arg Single submitter ⚠
- p.Gly469Ala Single submitter ⚠
- p.Gly555Ser Single submitter ⚠
- p.Gly600Val Single submitter ⚠
- p.Gly687Ser Single submitter ⚠
- p.His611Tyr Single submitter ⚠
- p.His752Gln Single submitter ⚠
- p.Ile379Phe Single submitter ⚠
- p.Ile564Leu Single submitter ⚠
- p.Ile708Val Single submitter ⚠
- p.Leu407Phe Single submitter ⚠
- p.Leu613His Single submitter ⚠
- p.Leu779Pro Single submitter ⚠
- p.Lys356Asn Single submitter ⚠
- p.Lys480Asn Single submitter ⚠
- p.Met419Lys Single submitter ⚠
- p.Met485Val Single submitter ⚠
- p.Met503Ile Single submitter ⚠
- p.Met739Val Single submitter ⚠
- p.Pro460Leu Single submitter ⚠
- p.Pro525Leu Single submitter ⚠
- p.Pro528Leu Single submitter ⚠
- p.Pro537Ser Single submitter ⚠
- p.Pro543Arg Single submitter ⚠
- p.Pro569Leu Single submitter ⚠
- p.Pro579Leu Single submitter ⚠
- p.Pro636His Single submitter ⚠
- p.Pro638Leu Single submitter ⚠
- p.Pro641Leu Single submitter ⚠
- p.Pro663Ser Single submitter ⚠
- p.Pro668Arg Single submitter ⚠
- p.Pro715Ser Single submitter ⚠
- p.Pro754Ser Single submitter ⚠
- p.Pro755Ser Single submitter ⚠
- p.Pro764Leu Single submitter ⚠
- p.Pro795Leu Single submitter ⚠
- p.Pro797Gln Single submitter ⚠
- p.Pro812Ala Single submitter ⚠
- p.Pro813Arg Single submitter ⚠
- p.Pro813His Single submitter ⚠
- p.Pro865Ser Single submitter ⚠
- p.Ser397Asn Single submitter ⚠
- p.Ser474Pro Single submitter ⚠
- p.Ser546Asn Single submitter ⚠
- p.Ser547Cys Single submitter ⚠
- p.Ser552Gly Single submitter ⚠
- p.Ser655Asn Single submitter ⚠
- p.Ser657Leu Single submitter ⚠
- p.Ser772Arg Single submitter ⚠
- p.Ser840Phe Single submitter ⚠
- p.Thr307Ala Single submitter ⚠
- p.Thr38Met Single submitter ⚠
- p.Thr530Ile Single submitter ⚠
- p.Thr628Ile Single submitter ⚠
- p.Thr679Ile Single submitter ⚠
- p.Thr759Ala Single submitter ⚠
- p.Thr838Ala Single submitter ⚠
- p.Thr96Met Single submitter ⚠
- p.Val320Ile Single submitter ⚠
- p.Val535Met Single submitter ⚠
- p.Val536Met Single submitter ⚠
- p.Val587Leu Single submitter ⚠
- p.Val633Ile Single submitter ⚠