ARHGAP22 — 148 ClinVar variants
All ClinVar germline ARHGAP22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 132 flagged for review →
2 Benign · 11 Likely benign · 135 Uncertain significance
Full ARHGAP22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 132
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 113
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP22 p.Ala172Val Uncertain significance Single submitter
- ARHGAP22 p.Ala200Ser Uncertain significance Single submitter
- ARHGAP22 p.Ala246Ser Uncertain significance Single submitter
- ARHGAP22 p.Ala351Thr Uncertain significance Single submitter
- ARHGAP22 p.Ala351Val Uncertain significance Single submitter
- ARHGAP22 p.Ala531Ser Uncertain significance Single submitter
- ARHGAP22 p.Ala573Glu Uncertain significance Single submitter
- ARHGAP22 p.Ala696Val Uncertain significance Single submitter
- ARHGAP22 p.Arg113Gln Uncertain significance Single submitter
- ARHGAP22 p.Arg195Cys Uncertain significance Single submitter
- ARHGAP22 p.Arg195His Uncertain significance Single submitter
- ARHGAP22 p.Arg24Gln Uncertain significance Single submitter
- ARHGAP22 p.Arg28Gln Uncertain significance Single submitter
- ARHGAP22 p.Arg28Trp Uncertain significance Single submitter
- ARHGAP22 p.Arg361Cys Uncertain significance Single submitter
- ARHGAP22 p.Arg479Gln Uncertain significance Single submitter
- ARHGAP22 p.Arg479Trp Uncertain significance Single submitter
- ARHGAP22 p.Arg57His Uncertain significance Single submitter
- ARHGAP22 p.Arg62Cys Uncertain significance Single submitter
- ARHGAP22 p.Arg637Trp Uncertain significance Single submitter
- ARHGAP22 p.Arg657Gln Uncertain significance Single submitter
- ARHGAP22 p.Arg661Gln Uncertain significance Single submitter
- ARHGAP22 p.Arg663Gln Uncertain significance Single submitter
- ARHGAP22 p.Arg7Lys Uncertain significance Single submitter
- ARHGAP22 p.Asn282His Uncertain significance Single submitter
- ARHGAP22 p.Asp261Asn Uncertain significance Single submitter
- ARHGAP22 p.Asp546His Uncertain significance Single submitter
- ARHGAP22 p.Asp565Asn Uncertain significance Single submitter
- ARHGAP22 p.Asp630Gly Uncertain significance Single submitter
- ARHGAP22 p.Cys366Arg Uncertain significance Single submitter
- ARHGAP22 p.Gln272Arg Uncertain significance Single submitter
- ARHGAP22 p.Gln423Arg Uncertain significance Single submitter
- ARHGAP22 p.Gln78Leu Uncertain significance Single submitter
- ARHGAP22 p.Glu121Asp Uncertain significance Single submitter
- ARHGAP22 p.Glu21Asp Uncertain significance Single submitter
- ARHGAP22 p.Glu249Lys Uncertain significance Single submitter
- ARHGAP22 p.Glu382Lys Uncertain significance Single submitter
- ARHGAP22 p.Glu618Lys Uncertain significance Single submitter
- ARHGAP22 p.Glu625Lys Uncertain significance Single submitter
- ARHGAP22 p.Glu640Gly Uncertain significance Single submitter
- ARHGAP22 p.Glu679Asp Uncertain significance Single submitter
- ARHGAP22 p.Glu96Lys Uncertain significance Single submitter
- ARHGAP22 p.Gly111Trp Uncertain significance Single submitter
- ARHGAP22 p.Gly150Arg Uncertain significance Single submitter
- ARHGAP22 p.Gly384Arg Uncertain significance Single submitter
- ARHGAP22 p.Gly398Trp Uncertain significance Single submitter
- ARHGAP22 p.Gly444Trp Uncertain significance Single submitter
- ARHGAP22 p.Gly445Asp Uncertain significance Single submitter
- ARHGAP22 p.Gly457Arg Uncertain significance Single submitter
- ARHGAP22 p.Gly499Asp Uncertain significance Single submitter
- ARHGAP22 p.Gly503Val Uncertain significance Single submitter
- ARHGAP22 p.Gly690Glu Uncertain significance Single submitter
- ARHGAP22 p.His163Gln Uncertain significance Single submitter
- ARHGAP22 p.His592Arg Uncertain significance Single submitter
- ARHGAP22 p.His592Gln Uncertain significance Single submitter
- ARHGAP22 p.Ile287Val Uncertain significance Single submitter
- ARHGAP22 p.Ile453Val Uncertain significance Single submitter
- ARHGAP22 p.Leu124Pro Uncertain significance Single submitter
- ARHGAP22 p.Leu238Ile Uncertain significance Single submitter
- ARHGAP22 p.Leu404Val Uncertain significance Single submitter
- ARHGAP22 p.Leu489Phe Uncertain significance Single submitter
- ARHGAP22 p.Leu549Gln Uncertain significance Single submitter
- ARHGAP22 p.Leu83Ile Uncertain significance Single submitter
- ARHGAP22 p.Leu83Pro Uncertain significance Single submitter
- ARHGAP22 p.Lys443Met Uncertain significance Single submitter
- ARHGAP22 p.Lys52Arg Uncertain significance Single submitter
- ARHGAP22 p.Lys647Glu Uncertain significance Single submitter
- ARHGAP22 p.Lys698Glu Uncertain significance Single submitter
- ARHGAP22 p.Lys70Glu Uncertain significance Single submitter
- ARHGAP22 p.Met29Ile Uncertain significance Single submitter
- ARHGAP22 p.Met462Val Uncertain significance Single submitter
- ARHGAP22 p.Met570Ile Uncertain significance Single submitter
- ARHGAP22 p.Met651Leu Uncertain significance Single submitter
- ARHGAP22 p.Met651Val Uncertain significance Single submitter
- ARHGAP22 p.Pro117Leu Uncertain significance Single submitter
- ARHGAP22 p.Pro120Arg Uncertain significance Single submitter
- ARHGAP22 p.Pro197Leu Uncertain significance Single submitter
- ARHGAP22 p.Pro30Arg Uncertain significance Single submitter
- ARHGAP22 p.Pro30Leu Uncertain significance Single submitter
- ARHGAP22 p.Pro352Leu Uncertain significance Single submitter
- ARHGAP22 p.Pro354Leu Uncertain significance Single submitter
- ARHGAP22 p.Pro360Leu Uncertain significance Single submitter
- ARHGAP22 p.Pro426Leu Uncertain significance Single submitter
- ARHGAP22 p.Pro426Ser Uncertain significance Single submitter
- ARHGAP22 p.Pro496Ala Uncertain significance Single submitter
- ARHGAP22 p.Pro498Leu Uncertain significance Single submitter
- ARHGAP22 p.Pro555Leu Uncertain significance Single submitter
- ARHGAP22 p.Pro582Leu Uncertain significance Single submitter
- ARHGAP22 p.Pro95Thr Uncertain significance Single submitter
- ARHGAP22 p.Pro98Leu Uncertain significance Single submitter
- ARHGAP22 p.Ser253Gly Uncertain significance Single submitter
- ARHGAP22 p.Ser274Thr Uncertain significance Single submitter
- ARHGAP22 p.Ser359Phe Uncertain significance Single submitter
- ARHGAP22 p.Ser379Arg Uncertain significance Single submitter
- ARHGAP22 p.Ser379Asn Uncertain significance Single submitter
- ARHGAP22 p.Ser417Asn Uncertain significance Single submitter
- ARHGAP22 p.Ser430Cys Uncertain significance Single submitter
- ARHGAP22 p.Ser527Asn Uncertain significance Single submitter
- ARHGAP22 p.Ser557Asn Uncertain significance Single submitter
- ARHGAP22 p.Ser563Phe Uncertain significance Single submitter
- ARHGAP22 p.Ser583Arg Uncertain significance Single submitter
- ARHGAP22 p.Thr189Ala Uncertain significance Single submitter
- ARHGAP22 p.Thr222Ala Uncertain significance Single submitter
- ARHGAP22 p.Thr226Met Uncertain significance Single submitter
- ARHGAP22 p.Thr266Ile Uncertain significance Single submitter
- ARHGAP22 p.Thr350Met Uncertain significance Single submitter
- ARHGAP22 p.Thr410Ala Uncertain significance Single submitter
- ARHGAP22 p.Thr530Met Uncertain significance Single submitter
- ARHGAP22 p.Tyr234Asn Uncertain significance Single submitter
- ARHGAP22 p.Tyr68Phe Uncertain significance Single submitter
- ARHGAP22 p.Val311Ile Uncertain significance Single submitter
- ARHGAP22 p.Val334Ile Uncertain significance Single submitter
- ARHGAP22 p.Val403Leu Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- ARHGAP22 p.Ala662Val Uncertain significance Single submitter
- ARHGAP22 p.Arg170Cys Uncertain significance Single submitter
- ARHGAP22 p.Arg170His Uncertain significance Single submitter
- ARHGAP22 p.Arg472Cys Uncertain significance Single submitter
- ARHGAP22 p.Arg473Trp Uncertain significance Single submitter
- ARHGAP22 p.Arg62Leu Uncertain significance Single submitter
- ARHGAP22 p.Asn670Lys Uncertain significance Single submitter
- ARHGAP22 p.Gly168Asp Uncertain significance Single submitter
- ARHGAP22 p.Gly85Arg Uncertain significance Single submitter
- ARHGAP22 p.Gly85Glu Uncertain significance Single submitter
- ARHGAP22 p.Ile6Asn Uncertain significance Single submitter
- ARHGAP22 p.Leu252Phe Uncertain significance Single submitter
- ARHGAP22 p.Leu276Phe Uncertain significance Single submitter
- ARHGAP22 p.Lys5Asn Uncertain significance Single submitter
- ARHGAP22 p.Lys655Asn Uncertain significance Single submitter
- ARHGAP22 p.Met328Val Uncertain significance Single submitter
- ARHGAP22 p.Phe153Ser Uncertain significance Single submitter
- ARHGAP22 p.Val38Met Uncertain significance Single submitter
-
ARHGAP22 p.Lys5Thr
Likely benign
No assertion criteria
long QT syndrome
All ARHGAP22 variants
Benign 2
- p.Ala662= Multiple submitters
- p.Arg612Cys Single submitter
Likely benign 11
- c.989-110T>C Single submitter
- c.989-189C>T Single submitter
- c.989-385A>G Single submitter
- p.Ala575Thr Single submitter
- p.Arg590Gln Single submitter
- p.Arg637Gln Single submitter
- p.Glu185Gln Single submitter
- p.Leu564Pro Single submitter
- p.Lys646Arg Single submitter
- p.Pro498= Single submitter
- p.Lys5Thr No assertion criteria long QT syndrome ⚠
Uncertain significance 135
- c.660-2A>G Single submitter
- p.Ala172Val Single submitter ⚠
- p.Ala200Ser Single submitter ⚠
- p.Ala246Ser Single submitter ⚠
- p.Ala351Thr Single submitter ⚠
- p.Ala351Val Single submitter ⚠
- p.Ala531Ser Single submitter ⚠
- p.Ala573Glu Single submitter ⚠
- p.Ala662Val Single submitter ⚠
- p.Ala696Val Single submitter ⚠
- p.Arg113Gln Single submitter ⚠
- p.Arg170Cys Single submitter ⚠
- p.Arg170His Single submitter ⚠
- p.Arg195Cys Single submitter ⚠
- p.Arg195His Single submitter ⚠
- p.Arg24Gln Single submitter ⚠
- p.Arg28Gln Single submitter ⚠
- p.Arg28Trp Single submitter ⚠
- p.Arg318Trp Single submitter
- p.Arg361Cys Single submitter ⚠
- p.Arg472Cys Single submitter ⚠
- p.Arg473Trp Single submitter ⚠
- p.Arg479Gln Single submitter ⚠
- p.Arg479Trp Single submitter ⚠
- p.Arg57Cys Single submitter
- p.Arg57His Single submitter ⚠
- p.Arg62Cys Single submitter ⚠
- p.Arg62Leu Single submitter ⚠
- p.Arg637Trp Single submitter ⚠
- p.Arg657Gln Single submitter ⚠
- p.Arg661Gln Single submitter ⚠
- p.Arg663Gln Single submitter ⚠
- p.Arg7Lys Single submitter ⚠
- p.Asn282His Single submitter ⚠
- p.Asn670Lys Single submitter ⚠
- p.Asp261Asn Single submitter ⚠
- p.Asp546His Single submitter ⚠
- p.Asp565Asn Single submitter ⚠
- p.Asp630Gly Single submitter ⚠
- p.Cys366Arg Single submitter ⚠
- p.Gln272Arg Single submitter ⚠
- p.Gln423Arg Single submitter ⚠
- p.Gln78Leu Single submitter ⚠
- p.Glu121Asp Single submitter ⚠
- p.Glu21Asp Single submitter ⚠
- p.Glu249Lys Single submitter ⚠
- p.Glu382Lys Single submitter ⚠
- p.Glu618Lys Single submitter ⚠
- p.Glu625Lys Single submitter ⚠
- p.Glu640Gly Single submitter ⚠
- p.Glu679Asp Single submitter ⚠
- p.Glu96Lys Single submitter ⚠
- p.Gly111Trp Single submitter ⚠
- p.Gly150Arg Single submitter ⚠
- p.Gly168Asp Single submitter ⚠
- p.Gly384Arg Single submitter ⚠
- p.Gly398Trp Single submitter ⚠
- p.Gly444Trp Single submitter ⚠
- p.Gly445Asp Single submitter ⚠
- p.Gly457Arg Single submitter ⚠
- p.Gly499Asp Single submitter ⚠
- p.Gly503Val Single submitter ⚠
- p.Gly690Glu Single submitter ⚠
- p.Gly85Arg Single submitter ⚠
- p.Gly85Glu Single submitter ⚠
- p.His163Gln Single submitter ⚠
- p.His592Arg Single submitter ⚠
- p.His592Gln Single submitter ⚠
- p.Ile287Val Single submitter ⚠
- p.Ile453Val Single submitter ⚠
- p.Ile6Asn Single submitter ⚠
- p.Leu124Pro Single submitter ⚠
- p.Leu238Ile Single submitter ⚠
- p.Leu252Phe Single submitter ⚠
- p.Leu276Phe Single submitter ⚠
- p.Leu404Val Single submitter ⚠
- p.Leu489Phe Single submitter ⚠
- p.Leu549Gln Single submitter ⚠
- p.Leu83Ile Single submitter ⚠
- p.Leu83Pro Single submitter ⚠
- p.Lys443Met Single submitter ⚠
- p.Lys52Arg Single submitter ⚠
- p.Lys5Asn Single submitter ⚠
- p.Lys647Glu Single submitter ⚠
- p.Lys655Asn Single submitter ⚠
- p.Lys698Glu Single submitter ⚠
- p.Lys70Glu Single submitter ⚠
- p.Met29Ile Single submitter ⚠
- p.Met328Val Single submitter ⚠
- p.Met462Val Single submitter ⚠
- p.Met570Ile Single submitter ⚠
- p.Met651Leu Single submitter ⚠
- p.Met651Val Single submitter ⚠
- p.Phe153Ser Single submitter ⚠
- p.Pro117Leu Single submitter ⚠
- p.Pro120Arg Single submitter ⚠
- p.Pro147Leu Single submitter
- p.Pro197Leu Single submitter ⚠
- p.Pro30Arg Single submitter ⚠
- p.Pro30Leu Single submitter ⚠
- p.Pro352Leu Single submitter ⚠
- p.Pro354Leu Single submitter ⚠
- p.Pro360Leu Single submitter ⚠
- p.Pro426Leu Single submitter ⚠
- p.Pro426Ser Single submitter ⚠
- p.Pro496Ala Single submitter ⚠
- p.Pro498Leu Single submitter ⚠
- p.Pro555Leu Single submitter ⚠
- p.Pro582Leu Single submitter ⚠
- p.Pro95Thr Single submitter ⚠
- p.Pro98Leu Single submitter ⚠
- p.Ser253Gly Single submitter ⚠
- p.Ser274Thr Single submitter ⚠
- p.Ser359Phe Single submitter ⚠
- p.Ser379Arg Single submitter ⚠
- p.Ser379Asn Single submitter ⚠
- p.Ser417Asn Single submitter ⚠
- p.Ser430Cys Single submitter ⚠
- p.Ser527Asn Single submitter ⚠
- p.Ser557Asn Single submitter ⚠
- p.Ser563Phe Single submitter ⚠
- p.Ser583Arg Single submitter ⚠
- p.Thr189Ala Single submitter ⚠
- p.Thr222Ala Single submitter ⚠
- p.Thr226Met Single submitter ⚠
- p.Thr266Ile Single submitter ⚠
- p.Thr350Met Single submitter ⚠
- p.Thr410Ala Single submitter ⚠
- p.Thr530Met Single submitter ⚠
- p.Tyr234Asn Single submitter ⚠
- p.Tyr68Phe Single submitter ⚠
- p.Val311Ile Single submitter ⚠
- p.Val334Ile Single submitter ⚠
- p.Val38Met Single submitter ⚠
- p.Val403Leu Single submitter ⚠