ARHGAP25 — 83 ClinVar variants

All ClinVar germline ARHGAP25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more.

3 Benign · 6 Likely benign · 74 Uncertain significance

Full ARHGAP25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

All ARHGAP25 variants

Benign 3

c.675-8T>C Single submitter
p.Ala417= Single submitter
p.Thr486= Single submitter

Likely benign 6

p.Arg492His Single submitter
p.Gln523His Single submitter
p.Pro419Leu Single submitter
p.Thr406Ala Single submitter
p.Glu254Lys No assertion criteria ARHGAP25-related condition
p.Pro355= No assertion criteria ARHGAP25-related condition

Uncertain significance 74

p.Ala101Thr Single submitter
p.Ala265Val Single submitter
p.Ala33Thr Single submitter
p.Ala34Thr Single submitter
p.Ala374Thr Single submitter
p.Ala517Thr Single submitter
p.Arg161His Single submitter
p.Arg193Gln Single submitter
p.Arg220Trp Single submitter
p.Arg241Gln Single submitter
p.Arg283His Single submitter
p.Arg323Met Single submitter
p.Arg334Lys Single submitter
p.Arg485Gly Single submitter
p.Arg499Gln Single submitter
p.Arg499Trp Single submitter
p.Arg562Leu Single submitter
p.Arg612Cys Single submitter
p.Arg612His Single submitter
p.Arg618Gln Single submitter
p.Arg618Trp Single submitter
p.Asn545Ser Single submitter
p.Asp284Asn Single submitter
p.Asp384Val Single submitter
p.Asp416Glu Single submitter
p.Asp421His Single submitter
p.Asp496Val Single submitter
p.Asp504Asn Single submitter
p.Gln456Pro Single submitter
p.Gln555His Single submitter
p.Gln568Glu Single submitter
p.Glu182Lys Single submitter
p.Glu267Asp Single submitter
p.Glu420Lys Single submitter
p.Glu548Lys Single submitter
p.Glu549Lys Single submitter
p.Glu645Lys Single submitter
p.Gly173Ser Single submitter
p.Gly255Arg Single submitter
p.Gly411Arg Single submitter
p.Gly514Trp Single submitter
p.Gly540Glu Single submitter
p.Ile280Val Single submitter
p.Leu611Phe Single submitter
p.Lys358Glu Single submitter
p.Lys373Asn Single submitter
p.Lys439Ile Single submitter
p.Met345Arg Single submitter
p.Met90Val Single submitter
p.Pro246Ser Single submitter
p.Pro361Leu Single submitter
p.Pro361Thr Single submitter
p.Pro93Ala Single submitter
p.Ser38Leu Single submitter
p.Ser396Ile Single submitter
p.Ser423Gly Single submitter
p.Ser423Thr Single submitter
p.Ser472Leu Single submitter
p.Ser508Tyr Single submitter
p.Ser534Arg Single submitter
p.Thr394Ile Single submitter
p.Thr394Pro Single submitter
p.Thr406Ser Single submitter
p.Thr410Asn Single submitter
p.Thr441Ile Single submitter
p.Thr500Ala Single submitter
p.Thr96Ser Single submitter
p.Tyr168Cys Single submitter
p.Tyr77His Single submitter
p.Val15Leu Single submitter
p.Val305Ile Single submitter
p.Val326Ile Single submitter
p.Val558Ala Single submitter
p.Val591Leu Single submitter