ARHGAP26 — 84 ClinVar variants
All ClinVar germline ARHGAP26 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
8 Benign · 10 Likely benign · 66 Uncertain significance
Full ARHGAP26 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP26 c.2099+147C>T Uncertain significance Single submitter
- ARHGAP26 c.2099+149G>A Uncertain significance Single submitter
- ARHGAP26 c.2099+38G>C Uncertain significance Single submitter
- ARHGAP26 c.2099+93A>G Uncertain significance Single submitter
- ARHGAP26 p.Ala126Thr Uncertain significance Single submitter
- ARHGAP26 p.Ala477Thr Uncertain significance Single submitter
- ARHGAP26 p.Ala56Val Uncertain significance Single submitter
- ARHGAP26 p.Ala579Pro Uncertain significance Single submitter
- ARHGAP26 p.Ala75Thr Uncertain significance Single submitter
- ARHGAP26 p.Arg585Gln Uncertain significance Single submitter
-
ARHGAP26 p.Asn417Ser
Uncertain significance
Single submitter
juvenile myelomonocytic leukemia
- ARHGAP26 p.Asn481Ser Uncertain significance Single submitter
- ARHGAP26 p.Asn563His Uncertain significance Single submitter
- ARHGAP26 p.Asn621Asp Uncertain significance Single submitter
- ARHGAP26 p.Asp342Asn Uncertain significance Single submitter
- ARHGAP26 p.Asp649Asn Uncertain significance Single submitter
- ARHGAP26 p.Asp695Val Uncertain significance Single submitter
- ARHGAP26 p.Asp729Asn Uncertain significance Single submitter
- ARHGAP26 p.Gln615Lys Uncertain significance Single submitter
- ARHGAP26 p.Glu339Lys Uncertain significance Single submitter
- ARHGAP26 p.His17Tyr Uncertain significance Single submitter
- ARHGAP26 p.Ile144Val Uncertain significance Single submitter
- ARHGAP26 p.Ile347Thr Uncertain significance Single submitter
- ARHGAP26 p.Ile47Thr Uncertain significance Single submitter
- ARHGAP26 p.Lys422Thr Uncertain significance Single submitter
- ARHGAP26 p.Met645Val Uncertain significance Single submitter
- ARHGAP26 p.Phe473Leu Uncertain significance Single submitter
- ARHGAP26 p.Pro344Ser Uncertain significance Single submitter
- ARHGAP26 p.Pro657His Uncertain significance Single submitter
- ARHGAP26 p.Pro664Thr Uncertain significance Single submitter
- ARHGAP26 p.Pro665Leu Uncertain significance Single submitter
- ARHGAP26 p.Ser15Gly Uncertain significance Single submitter
- ARHGAP26 p.Ser231Asn Uncertain significance Single submitter
- ARHGAP26 p.Ser387Asn Uncertain significance Single submitter
- ARHGAP26 p.Ser628Leu Uncertain significance Single submitter
- ARHGAP26 p.Ser640Asn Uncertain significance Single submitter
- ARHGAP26 p.Ser685Asn Uncertain significance Single submitter
- ARHGAP26 p.Thr242Ala Uncertain significance Single submitter
- ARHGAP26 p.Thr610Ile Uncertain significance Single submitter
- ARHGAP26 p.Thr701Ala Uncertain significance Single submitter
- ARHGAP26 p.Val416Asp Uncertain significance Single submitter
- ARHGAP26 p.Val530Met Uncertain significance Single submitter
- ARHGAP26 p.Val571Met Uncertain significance Single submitter
- ARHGAP26 p.Val756Met Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- ARHGAP26 p.Ala163Ser Uncertain significance Single submitter
- ARHGAP26 p.Arg367Trp Uncertain significance Single submitter
- ARHGAP26 p.Arg58Gln Uncertain significance Single submitter
- ARHGAP26 p.Arg58Leu Uncertain significance Single submitter
- ARHGAP26 p.Arg659Trp Uncertain significance Single submitter
- ARHGAP26 p.Asp342Gly Uncertain significance Single submitter
- ARHGAP26 p.Asp439Gly Uncertain significance Single submitter
- ARHGAP26 p.Gln227His Uncertain significance Single submitter
- ARHGAP26 p.Gln421His Uncertain significance Single submitter
- ARHGAP26 p.Glu110Lys Uncertain significance Single submitter
- ARHGAP26 p.Glu20Gly Uncertain significance Single submitter
- ARHGAP26 p.Gly311Glu Uncertain significance Single submitter
- ARHGAP26 p.His260Gln Uncertain significance Single submitter
- ARHGAP26 p.Leu576Phe Uncertain significance Single submitter
- ARHGAP26 p.Lys41Asn Uncertain significance Single submitter
- ARHGAP26 p.Lys519Arg Uncertain significance Single submitter
- ARHGAP26 p.Met508Val Uncertain significance Single submitter
- ARHGAP26 p.Pro675Thr Uncertain significance Single submitter
- ARHGAP26 p.Ser591Phe Uncertain significance Single submitter
- ARHGAP26 p.Ser681Leu Uncertain significance Single submitter
- ARHGAP26 p.Thr602Met Uncertain significance Single submitter
- ARHGAP26 p.Tyr273Cys Uncertain significance Single submitter
- ARHGAP26 p.Val699Ile Likely benign Single submitter
All ARHGAP26 variants
Benign 8
- c.598-7A>G Single submitter
- c.*3558C>T Single submitter
- p.Ser109= Single submitter
- p.Ser721= Single submitter
- c.154+462T>C No assertion criteria ARHGAP26-related disorder
- p.Arg85= No assertion criteria ARHGAP26-related disorder
- p.Asn730= No assertion criteria ARHGAP26-related disorder
- p.Gly415= No assertion criteria ARHGAP26-related disorder
Likely benign 10
- p.Leu663= Single submitter
- p.Thr606Ala Single submitter
- p.Val699Ile Single submitter ⚠
- c.1285+9C>T No assertion criteria ARHGAP26-related disorder
- c.1838-10T>C No assertion criteria ARHGAP26-related disorder
- c.486+7G>A No assertion criteria ARHGAP26-related disorder
- p.Asp649= No assertion criteria ARHGAP26-related disorder
- p.His564= No assertion criteria ARHGAP26-related disorder
- p.Ile557Val No assertion criteria ARHGAP26-related disorder
- p.Thr570= No assertion criteria ARHGAP26-related disorder
Uncertain significance 66
- c.2099+147C>T Single submitter ⚠
- c.2099+149G>A Single submitter ⚠
- c.2099+38G>C Single submitter ⚠
- c.2099+93A>G Single submitter ⚠
- p.Ala126Thr Single submitter ⚠
- p.Ala163Ser Single submitter ⚠
- p.Ala477Thr Single submitter ⚠
- p.Ala56Val Single submitter ⚠
- p.Ala579Pro Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Arg367Trp Single submitter ⚠
- p.Arg585Gln Single submitter ⚠
- p.Arg58Gln Single submitter ⚠
- p.Arg58Leu Single submitter ⚠
- p.Arg659Trp Single submitter ⚠
- p.Asn417Ser Single submitter juvenile myelomonocytic leukemia ⚠
- p.Asn481Ser Single submitter ⚠
- p.Asn563His Single submitter ⚠
- p.Asn621Asp Single submitter ⚠
- p.Asp342Asn Single submitter ⚠
- p.Asp342Gly Single submitter ⚠
- p.Asp439Gly Single submitter ⚠
- p.Asp649Asn Single submitter ⚠
- p.Asp695Val Single submitter ⚠
- p.Asp729Asn Single submitter ⚠
- p.Gln227His Single submitter ⚠
- p.Gln421His Single submitter ⚠
- p.Gln615Lys Single submitter ⚠
- p.Glu110Lys Single submitter ⚠
- p.Glu20Gly Single submitter ⚠
- p.Glu339Lys Single submitter ⚠
- p.Gly311Glu Single submitter ⚠
- p.His17Tyr Single submitter ⚠
- p.His260Gln Single submitter ⚠
- p.Ile144Val Single submitter ⚠
- p.Ile347Thr Single submitter ⚠
- p.Ile47Thr Single submitter ⚠
- p.Leu576Phe Single submitter ⚠
- p.Lys41Asn Single submitter ⚠
- p.Lys422Thr Single submitter ⚠
- p.Lys519Arg Single submitter ⚠
- p.Met508Val Single submitter ⚠
- p.Met645Val Single submitter ⚠
- p.Phe473Leu Single submitter ⚠
- p.Pro344Ser Single submitter ⚠
- p.Pro657His Single submitter ⚠
- p.Pro664Thr Single submitter ⚠
- p.Pro665Leu Single submitter ⚠
- p.Pro675Thr Single submitter ⚠
- p.Ser15Gly Single submitter ⚠
- p.Ser231Asn Single submitter ⚠
- p.Ser387Asn Single submitter ⚠
- p.Ser591Phe Single submitter ⚠
- p.Ser628Leu Single submitter ⚠
- p.Ser640Asn Single submitter ⚠
- p.Ser681Leu Single submitter ⚠
- p.Ser685Asn Single submitter ⚠
- p.Thr242Ala Single submitter ⚠
- p.Thr602Met Single submitter ⚠
- p.Thr610Ile Single submitter ⚠
- p.Thr701Ala Single submitter ⚠
- p.Tyr273Cys Single submitter ⚠
- p.Val416Asp Single submitter ⚠
- p.Val530Met Single submitter ⚠
- p.Val571Met Single submitter ⚠
- p.Val756Met Single submitter ⚠