ARHGAP27 — 128 ClinVar variants
All ClinVar germline ARHGAP27 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 107 flagged for review →
12 Likely benign · 116 Uncertain significance
Full ARHGAP27 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 107
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP27 p.Ala194Val Uncertain significance Single submitter
- ARHGAP27 p.Ala490Pro Uncertain significance Single submitter
- ARHGAP27 p.Ala569Thr Uncertain significance Single submitter
- ARHGAP27 p.Ala646Gly Uncertain significance Single submitter
- ARHGAP27 p.Ala646Thr Uncertain significance Single submitter
- ARHGAP27 p.Ala701Thr Uncertain significance Single submitter
- ARHGAP27 p.Ala770Thr Uncertain significance Single submitter
- ARHGAP27 p.Ala86Thr Uncertain significance Single submitter
- ARHGAP27 p.Ala87Ser Uncertain significance Single submitter
- ARHGAP27 p.Arg450Gly Uncertain significance Single submitter
- ARHGAP27 p.Arg516Trp Uncertain significance Single submitter
- ARHGAP27 p.Arg576Gly Uncertain significance Single submitter
- ARHGAP27 p.Arg635His Uncertain significance Single submitter
- ARHGAP27 p.Arg745Gly Uncertain significance Single submitter
- ARHGAP27 p.Arg856Leu Uncertain significance Single submitter
- ARHGAP27 p.Asp629Ala Uncertain significance Single submitter
- ARHGAP27 p.Asp727Gly Uncertain significance Single submitter
- ARHGAP27 p.Cys142Gly Uncertain significance Single submitter
- ARHGAP27 p.Cys830Arg Uncertain significance Single submitter
- ARHGAP27 p.Gln155Glu Uncertain significance Single submitter
- ARHGAP27 p.Gln219Glu Uncertain significance Single submitter
- ARHGAP27 p.Gln457His Uncertain significance Single submitter
- ARHGAP27 p.Glu581Gly Uncertain significance Single submitter
- ARHGAP27 p.Glu613Asp Uncertain significance Single submitter
- ARHGAP27 p.Glu89Gln Uncertain significance Single submitter
- ARHGAP27 p.Gly115Ser Uncertain significance Single submitter
- ARHGAP27 p.Gly122Cys Uncertain significance Single submitter
- ARHGAP27 p.Gly122Ser Uncertain significance Single submitter
- ARHGAP27 p.Gly631Arg Uncertain significance Single submitter
- ARHGAP27 p.Gly696Ser Uncertain significance Single submitter
- ARHGAP27 p.Ile718Val Uncertain significance Single submitter
- ARHGAP27 p.Leu143Pro Uncertain significance Single submitter
- ARHGAP27 p.Leu497Ser Uncertain significance Single submitter
- ARHGAP27 p.Leu744Gln Uncertain significance Single submitter
- ARHGAP27 p.Lys539Asn Uncertain significance Single submitter
- ARHGAP27 p.Met406Val Uncertain significance Single submitter
- ARHGAP27 p.Phe695Leu Uncertain significance Single submitter
- ARHGAP27 p.Phe791Leu Uncertain significance Single submitter
- ARHGAP27 p.Pro110Arg Uncertain significance Single submitter
- ARHGAP27 p.Pro150Ser Uncertain significance Single submitter
- ARHGAP27 p.Pro192Arg Uncertain significance Single submitter
- ARHGAP27 p.Pro356Leu Uncertain significance Single submitter
- ARHGAP27 p.Pro364Ala Uncertain significance Single submitter
- ARHGAP27 p.Pro394Leu Uncertain significance Single submitter
- ARHGAP27 p.Pro473Ala Uncertain significance Single submitter
- ARHGAP27 p.Pro619Leu Uncertain significance Single submitter
- ARHGAP27 p.Pro865Ser Uncertain significance Single submitter
- ARHGAP27 p.Ser118Arg Uncertain significance Single submitter
- ARHGAP27 p.Ser196Arg Uncertain significance Single submitter
- ARHGAP27 p.Thr768Ser Uncertain significance Single submitter
- ARHGAP27 p.Thr821Ile Uncertain significance Single submitter
- ARHGAP27 p.Thr867Ile Uncertain significance Single submitter
- ARHGAP27 p.Trp187Ser Uncertain significance Single submitter
- ARHGAP27 p.Val151Met Uncertain significance Single submitter
- ARHGAP27 p.Val418Met Uncertain significance Single submitter
- ARHGAP27 p.Val437Ile Uncertain significance Single submitter
Predictors split 51
The independent predictors disagree with each other — read with care.
- ARHGAP27 p.Ala154Val Uncertain significance Single submitter
- ARHGAP27 p.Ala164Val Uncertain significance Single submitter
- ARHGAP27 p.Ala522Asp Uncertain significance Single submitter
- ARHGAP27 p.Ala654Thr Likely benign Single submitter
- ARHGAP27 p.Ala698Val Uncertain significance Single submitter
- ARHGAP27 p.Ala76Thr Uncertain significance Single submitter
- ARHGAP27 p.Ala883Val Uncertain significance Single submitter
- ARHGAP27 p.Arg26His Uncertain significance Single submitter
- ARHGAP27 p.Arg505His Uncertain significance Single submitter
- ARHGAP27 p.Arg514Gln Uncertain significance Single submitter
- ARHGAP27 p.Arg583Trp Uncertain significance Single submitter
- ARHGAP27 p.Arg668Gln Uncertain significance Single submitter
- ARHGAP27 p.Arg668Gly Uncertain significance Single submitter
- ARHGAP27 p.Arg672His Uncertain significance Single submitter
- ARHGAP27 p.Arg709Gln Uncertain significance Single submitter
- ARHGAP27 p.Arg724His Uncertain significance Single submitter
- ARHGAP27 p.Asp159Tyr Uncertain significance Single submitter
- ARHGAP27 p.Asp197Gly Uncertain significance Single submitter
- ARHGAP27 p.Asp458His Uncertain significance Single submitter
- ARHGAP27 p.Asp595Asn Uncertain significance Single submitter
- ARHGAP27 p.Gln548Lys Uncertain significance Single submitter
- ARHGAP27 p.Glu415Asp Uncertain significance Single submitter
- ARHGAP27 p.Glu43Lys Uncertain significance Single submitter
- ARHGAP27 p.Glu484Lys Uncertain significance Single submitter
- ARHGAP27 p.Glu624Gln Uncertain significance Single submitter
- ARHGAP27 p.Glu624Lys Uncertain significance Single submitter
- ARHGAP27 p.Glu634Lys Uncertain significance Single submitter
- ARHGAP27 p.Glu686Asp Likely benign Single submitter
- ARHGAP27 p.Gly379Val Uncertain significance Single submitter
- ARHGAP27 p.Gly7Arg Uncertain significance Single submitter
- ARHGAP27 p.His15Gln Uncertain significance Single submitter
- ARHGAP27 p.His835Gln Uncertain significance Single submitter
- ARHGAP27 p.Ile728Thr Uncertain significance Single submitter
- ARHGAP27 p.Leu367Met Uncertain significance Single submitter
- ARHGAP27 p.Lys605Asn Uncertain significance Single submitter
- ARHGAP27 p.Met868Thr Uncertain significance Single submitter
- ARHGAP27 p.Pro150Leu Uncertain significance Single submitter
- ARHGAP27 p.Pro167Thr Uncertain significance Single submitter
- ARHGAP27 p.Pro779Ser Uncertain significance Single submitter
- ARHGAP27 p.Pro79Leu Uncertain significance Single submitter
- ARHGAP27 p.Pro887Arg Uncertain significance Single submitter
- ARHGAP27 p.Ser186Phe Uncertain significance Single submitter
- ARHGAP27 p.Ser683Leu Uncertain significance Single submitter
- ARHGAP27 p.Ser735Asn Uncertain significance Single submitter
- ARHGAP27 p.Thr602Ile Uncertain significance Single submitter
- ARHGAP27 p.Tyr58His Uncertain significance Single submitter
- ARHGAP27 p.Val27Leu Uncertain significance Single submitter
- ARHGAP27 p.Val378Met Uncertain significance Single submitter
- ARHGAP27 p.Val667Ala Uncertain significance Single submitter
- ARHGAP27 p.Val721Ile Uncertain significance Single submitter
- ARHGAP27 p.Val9Met Uncertain significance Single submitter
All ARHGAP27 variants
Likely benign 12
- p.Ala616Thr Single submitter
- p.Ala646Val Single submitter
- p.Ala654Thr Single submitter ⚠
- p.Ala720Thr Single submitter
- p.Arg789His Single submitter
- p.Arg802Gln Single submitter
- p.Glu622Asp Single submitter
- p.Glu644Asp Single submitter
- p.Glu686Asp Single submitter ⚠
- p.Gly545Ser Single submitter
- p.Gly656Ser Single submitter
- p.Leu655Pro Single submitter
Uncertain significance 116
- c.657+107G>T Single submitter
- c.657+130G>A Single submitter
- c.657+26G>A Single submitter
- c.657+31G>A Single submitter
- c.657+34T>A Single submitter
- c.657+38G>A Single submitter
- c.657+49C>T Single submitter
- c.657+53C>T Single submitter
- c.657+76G>A Single submitter
- c.657+7C>A Single submitter
- c.657+83G>A Single submitter
- p.Ala154Val Single submitter ⚠
- p.Ala164Val Single submitter ⚠
- p.Ala194Val Single submitter ⚠
- p.Ala490Pro Single submitter ⚠
- p.Ala522Asp Single submitter ⚠
- p.Ala569Thr Single submitter ⚠
- p.Ala646Gly Single submitter ⚠
- p.Ala646Thr Single submitter ⚠
- p.Ala698Val Single submitter ⚠
- p.Ala701Thr Single submitter ⚠
- p.Ala76Thr Single submitter ⚠
- p.Ala770Thr Single submitter ⚠
- p.Ala86Thr Single submitter ⚠
- p.Ala87Ser Single submitter ⚠
- p.Ala883Val Single submitter ⚠
- p.Arg26His Single submitter ⚠
- p.Arg450Gly Single submitter ⚠
- p.Arg505His Single submitter ⚠
- p.Arg514Gln Single submitter ⚠
- p.Arg516Trp Single submitter ⚠
- p.Arg576Gly Single submitter ⚠
- p.Arg583Trp Single submitter ⚠
- p.Arg635His Single submitter ⚠
- p.Arg668Gln Single submitter ⚠
- p.Arg668Gly Single submitter ⚠
- p.Arg672His Single submitter ⚠
- p.Arg709Gln Single submitter ⚠
- p.Arg724His Single submitter ⚠
- p.Arg745Gly Single submitter ⚠
- p.Arg856Leu Single submitter ⚠
- p.Asp159Tyr Single submitter ⚠
- p.Asp197Gly Single submitter ⚠
- p.Asp458His Single submitter ⚠
- p.Asp595Asn Single submitter ⚠
- p.Asp629Ala Single submitter ⚠
- p.Asp727Gly Single submitter ⚠
- p.Cys142Gly Single submitter ⚠
- p.Cys830Arg Single submitter ⚠
- p.Gln155Glu Single submitter ⚠
- p.Gln219Glu Single submitter ⚠
- p.Gln457His Single submitter ⚠
- p.Gln548Lys Single submitter ⚠
- p.Glu415Asp Single submitter ⚠
- p.Glu43Lys Single submitter ⚠
- p.Glu484Lys Single submitter ⚠
- p.Glu581Gly Single submitter ⚠
- p.Glu613Asp Single submitter ⚠
- p.Glu624Gln Single submitter ⚠
- p.Glu624Lys Single submitter ⚠
- p.Glu634Lys Single submitter ⚠
- p.Glu89Gln Single submitter ⚠
- p.Gly115Ser Single submitter ⚠
- p.Gly122Cys Single submitter ⚠
- p.Gly122Ser Single submitter ⚠
- p.Gly379Val Single submitter ⚠
- p.Gly631Arg Single submitter ⚠
- p.Gly696Ser Single submitter ⚠
- p.Gly7Arg Single submitter ⚠
- p.His15Gln Single submitter ⚠
- p.His835Gln Single submitter ⚠
- p.Ile718Val Single submitter ⚠
- p.Ile728Thr Single submitter ⚠
- p.Leu143Pro Single submitter ⚠
- p.Leu367Met Single submitter ⚠
- p.Leu497Ser Single submitter ⚠
- p.Leu744Gln Single submitter ⚠
- p.Lys539Asn Single submitter ⚠
- p.Lys605Asn Single submitter ⚠
- p.Met406Val Single submitter ⚠
- p.Met868Thr Single submitter ⚠
- p.Phe695Leu Single submitter ⚠
- p.Phe791Leu Single submitter ⚠
- p.Pro110Arg Single submitter ⚠
- p.Pro150Leu Single submitter ⚠
- p.Pro150Ser Single submitter ⚠
- p.Pro167Thr Single submitter ⚠
- p.Pro192Arg Single submitter ⚠
- p.Pro356Leu Single submitter ⚠
- p.Pro364Ala Single submitter ⚠
- p.Pro394Leu Single submitter ⚠
- p.Pro473Ala Single submitter ⚠
- p.Pro619Leu Single submitter ⚠
- p.Pro779Ser Single submitter ⚠
- p.Pro79Leu Single submitter ⚠
- p.Pro865Ser Single submitter ⚠
- p.Pro887Arg Single submitter ⚠
- p.Ser118Arg Single submitter ⚠
- p.Ser186Phe Single submitter ⚠
- p.Ser196Arg Single submitter ⚠
- p.Ser683Leu Single submitter ⚠
- p.Ser735Asn Single submitter ⚠
- p.Thr602Ile Single submitter ⚠
- p.Thr768Ser Single submitter ⚠
- p.Thr821Ile Single submitter ⚠
- p.Thr867Ile Single submitter ⚠
- p.Trp187Ser Single submitter ⚠
- p.Tyr58His Single submitter ⚠
- p.Val151Met Single submitter ⚠
- p.Val27Leu Single submitter ⚠
- p.Val378Met Single submitter ⚠
- p.Val418Met Single submitter ⚠
- p.Val437Ile Single submitter ⚠
- p.Val667Ala Single submitter ⚠
- p.Val721Ile Single submitter ⚠
- p.Val9Met Single submitter ⚠