ARHGAP28 — 85 ClinVar variants
All ClinVar germline ARHGAP28 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
1 Benign · 7 Likely benign · 77 Uncertain significance
Full ARHGAP28 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP28 p.Ala268Val Uncertain significance Single submitter
- ARHGAP28 p.Ala283Thr Uncertain significance Single submitter
- ARHGAP28 p.Ala357Val Uncertain significance Single submitter
- ARHGAP28 p.Ala502Val Uncertain significance Single submitter
- ARHGAP28 p.Ala707Ser Uncertain significance Single submitter
- ARHGAP28 p.Ala707Val Uncertain significance Single submitter
- ARHGAP28 p.Arg183His Uncertain significance Single submitter
- ARHGAP28 p.Arg508Thr Uncertain significance Single submitter
- ARHGAP28 p.Arg547Gly Uncertain significance Single submitter
- ARHGAP28 p.Arg567Cys Uncertain significance Single submitter
- ARHGAP28 p.Arg634Gln Uncertain significance Single submitter
- ARHGAP28 p.Asn256Ser Uncertain significance Single submitter
- ARHGAP28 p.Asn560Ser Uncertain significance Single submitter
- ARHGAP28 p.Asn591Ser Uncertain significance Single submitter
- ARHGAP28 p.Asp194Asn Uncertain significance Single submitter
- ARHGAP28 p.Asp194Tyr Uncertain significance Single submitter
- ARHGAP28 p.Asp273Glu Uncertain significance Single submitter
- ARHGAP28 p.Asp387Val Uncertain significance Single submitter
- ARHGAP28 p.Asp389Asn Uncertain significance Single submitter
- ARHGAP28 p.Asp443Gly Uncertain significance Single submitter
- ARHGAP28 p.Gln600His Uncertain significance Single submitter
- ARHGAP28 p.Gln673Arg Uncertain significance Single submitter
- ARHGAP28 p.Glu201Lys Uncertain significance Single submitter
- ARHGAP28 p.Glu246Asp Uncertain significance Single submitter
- ARHGAP28 p.Glu411Lys Uncertain significance Single submitter
- ARHGAP28 p.Glu554Asp Uncertain significance Single submitter
- ARHGAP28 p.His189Tyr Uncertain significance Single submitter
- ARHGAP28 p.His701Arg Uncertain significance Single submitter
- ARHGAP28 p.Ile168Met Uncertain significance Single submitter
- ARHGAP28 p.Ile244Val Uncertain significance Single submitter
- ARHGAP28 p.Ile349Met Uncertain significance Single submitter
- ARHGAP28 p.Ile575Val Uncertain significance Single submitter
- ARHGAP28 p.Ile668Val Uncertain significance Single submitter
- ARHGAP28 p.Ile684Met Uncertain significance Single submitter
- ARHGAP28 p.Leu193Val Uncertain significance Single submitter
- ARHGAP28 p.Lys277Arg Uncertain significance Single submitter
- ARHGAP28 p.Lys277Glu Uncertain significance Single submitter
- ARHGAP28 p.Lys490Glu Uncertain significance Single submitter
- ARHGAP28 p.Lys549Glu Uncertain significance Single submitter
- ARHGAP28 p.Lys578Glu Uncertain significance Single submitter
- ARHGAP28 p.Lys666Gln Uncertain significance Single submitter
- ARHGAP28 p.Lys685Glu Uncertain significance Single submitter
- ARHGAP28 p.Lys724Glu Uncertain significance Single submitter
- ARHGAP28 p.Met295Ile Uncertain significance Single submitter
- ARHGAP28 p.Pro237Leu Uncertain significance Single submitter
- ARHGAP28 p.Pro252Thr Uncertain significance Single submitter
- ARHGAP28 p.Pro261Ala Uncertain significance Single submitter
- ARHGAP28 p.Pro630Leu Uncertain significance Single submitter
- ARHGAP28 p.Pro639Leu Uncertain significance Single submitter
- ARHGAP28 p.Ser167Pro Uncertain significance Single submitter
- ARHGAP28 p.Ser336Phe Uncertain significance Single submitter
- ARHGAP28 p.Ser536Tyr Uncertain significance Single submitter
- ARHGAP28 p.Ser631Leu Uncertain significance Single submitter
- ARHGAP28 p.Thr185Ser Uncertain significance Single submitter
- ARHGAP28 p.Thr222Ile Uncertain significance Single submitter
- ARHGAP28 p.Thr297Met Uncertain significance Single submitter
- ARHGAP28 p.Thr594Met Uncertain significance Single submitter
- ARHGAP28 p.Tyr553Asn Uncertain significance Single submitter
- ARHGAP28 p.Val177Ile Uncertain significance Single submitter
- ARHGAP28 p.Val250Leu Uncertain significance Single submitter
- ARHGAP28 p.Val370Leu Uncertain significance Single submitter
- ARHGAP28 p.Val396Ala Uncertain significance Single submitter
- ARHGAP28 p.Val625Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- ARHGAP28 p.Ala502Glu Uncertain significance Single submitter
- ARHGAP28 p.Arg344Cys Uncertain significance Single submitter
- ARHGAP28 p.Arg390Gly Uncertain significance Single submitter
- ARHGAP28 p.Arg421Gln Uncertain significance Single submitter
- ARHGAP28 p.Asp334Glu Uncertain significance Single submitter
- ARHGAP28 p.Cys425Tyr Uncertain significance Single submitter
- ARHGAP28 p.His452Arg Uncertain significance Single submitter
- ARHGAP28 p.Ile566Thr Uncertain significance Single submitter
- ARHGAP28 p.Leu514Phe Uncertain significance Single submitter
- ARHGAP28 p.Lys391Met Uncertain significance Single submitter
- ARHGAP28 p.Phe672Leu Uncertain significance Single submitter
- ARHGAP28 p.Trp533Cys Uncertain significance Single submitter
- ARHGAP28 p.Tyr432Cys Uncertain significance Single submitter
- ARHGAP28 p.Val398Leu Uncertain significance Single submitter
All ARHGAP28 variants
Benign 1
- p.Cys683Tyr Multiple submitters
Likely benign 7
- c.2030+1907C>T Single submitter
- p.Ala510Thr Single submitter
- p.Asn519Ser Single submitter
- p.Glu260Asp Single submitter
- p.Leu59= Single submitter
- p.Leu613= Single submitter
- c.1734+46C>G No assertion criteria ARHGAP28-related disorder
Uncertain significance 77
- p.Ala268Val Single submitter ⚠
- p.Ala283Thr Single submitter ⚠
- p.Ala357Val Single submitter ⚠
- p.Ala502Glu Single submitter ⚠
- p.Ala502Val Single submitter ⚠
- p.Ala707Ser Single submitter ⚠
- p.Ala707Val Single submitter ⚠
- p.Arg183His Single submitter ⚠
- p.Arg344Cys Single submitter ⚠
- p.Arg390Gly Single submitter ⚠
- p.Arg421Gln Single submitter ⚠
- p.Arg508Thr Single submitter ⚠
- p.Arg547Gly Single submitter ⚠
- p.Arg567Cys Single submitter ⚠
- p.Arg634Gln Single submitter ⚠
- p.Asn256Ser Single submitter ⚠
- p.Asn560Ser Single submitter ⚠
- p.Asn591Ser Single submitter ⚠
- p.Asp194Asn Single submitter ⚠
- p.Asp194Tyr Single submitter ⚠
- p.Asp273Glu Single submitter ⚠
- p.Asp334Glu Single submitter ⚠
- p.Asp387Val Single submitter ⚠
- p.Asp389Asn Single submitter ⚠
- p.Asp443Gly Single submitter ⚠
- p.Cys425Tyr Single submitter ⚠
- p.Gln600His Single submitter ⚠
- p.Gln673Arg Single submitter ⚠
- p.Glu201Lys Single submitter ⚠
- p.Glu246Asp Single submitter ⚠
- p.Glu411Lys Single submitter ⚠
- p.Glu554Asp Single submitter ⚠
- p.His189Tyr Single submitter ⚠
- p.His452Arg Single submitter ⚠
- p.His701Arg Single submitter ⚠
- p.Ile168Met Single submitter ⚠
- p.Ile244Val Single submitter ⚠
- p.Ile349Met Single submitter ⚠
- p.Ile566Thr Single submitter ⚠
- p.Ile575Val Single submitter ⚠
- p.Ile668Val Single submitter ⚠
- p.Ile684Met Single submitter ⚠
- p.Leu193Val Single submitter ⚠
- p.Leu514Phe Single submitter ⚠
- p.Lys277Arg Single submitter ⚠
- p.Lys277Glu Single submitter ⚠
- p.Lys391Met Single submitter ⚠
- p.Lys490Glu Single submitter ⚠
- p.Lys549Glu Single submitter ⚠
- p.Lys578Glu Single submitter ⚠
- p.Lys666Gln Single submitter ⚠
- p.Lys685Glu Single submitter ⚠
- p.Lys724Glu Single submitter ⚠
- p.Met295Ile Single submitter ⚠
- p.Phe672Leu Single submitter ⚠
- p.Pro237Leu Single submitter ⚠
- p.Pro252Thr Single submitter ⚠
- p.Pro261Ala Single submitter ⚠
- p.Pro630Leu Single submitter ⚠
- p.Pro639Leu Single submitter ⚠
- p.Ser167Pro Single submitter ⚠
- p.Ser336Phe Single submitter ⚠
- p.Ser536Tyr Single submitter ⚠
- p.Ser631Leu Single submitter ⚠
- p.Thr185Ser Single submitter ⚠
- p.Thr222Ile Single submitter ⚠
- p.Thr297Met Single submitter ⚠
- p.Thr594Met Single submitter ⚠
- p.Trp533Cys Single submitter ⚠
- p.Tyr432Cys Single submitter ⚠
- p.Tyr553Asn Single submitter ⚠
- p.Val177Ile Single submitter ⚠
- p.Val250Leu Single submitter ⚠
- p.Val370Leu Single submitter ⚠
- p.Val396Ala Single submitter ⚠
- p.Val398Leu Single submitter ⚠
- p.Val625Ile Single submitter ⚠