ARHGAP36 — 58 ClinVar variants
All ClinVar germline ARHGAP36 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
5 Likely benign · 53 Uncertain significance
Full ARHGAP36 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP36 p.Ala13Val Uncertain significance Single submitter
- ARHGAP36 p.Ala200Asp Uncertain significance Single submitter
- ARHGAP36 p.Ala200Val Uncertain significance Single submitter
- ARHGAP36 p.Ala38Pro Uncertain significance Single submitter
- ARHGAP36 p.Ala417Val Uncertain significance Single submitter
- ARHGAP36 p.Ala485Ser Uncertain significance Single submitter
- ARHGAP36 p.Ala517Val Uncertain significance Single submitter
- ARHGAP36 p.Ala538Thr Uncertain significance Single submitter
- ARHGAP36 p.Arg12Ser Uncertain significance Single submitter
- ARHGAP36 p.Arg156Gly Uncertain significance Single submitter
- ARHGAP36 p.Arg416His Uncertain significance Single submitter
- ARHGAP36 p.Arg45Leu Uncertain significance Single submitter
- ARHGAP36 p.Arg45Ser Uncertain significance Single submitter
- ARHGAP36 p.Arg527Ser Uncertain significance Single submitter
- ARHGAP36 p.Arg531His Uncertain significance Single submitter
- ARHGAP36 p.Arg534Leu Uncertain significance Single submitter
- ARHGAP36 p.Asn42Lys Uncertain significance Single submitter
- ARHGAP36 p.Asp95Asn Uncertain significance Single submitter
- ARHGAP36 p.Glu119Lys Uncertain significance Single submitter
- ARHGAP36 p.Glu500Gln Uncertain significance Single submitter
- ARHGAP36 p.Gly255Arg Uncertain significance Single submitter
- ARHGAP36 p.His352Arg Uncertain significance Single submitter
- ARHGAP36 p.Ile215Thr Uncertain significance Single submitter
- ARHGAP36 p.Leu381Val Uncertain significance Single submitter
- ARHGAP36 p.Leu77Phe Uncertain significance Single submitter
- ARHGAP36 p.Lys223Glu Uncertain significance Single submitter
- ARHGAP36 p.Lys96Asn Uncertain significance Single submitter
- ARHGAP36 p.Lys9Arg Uncertain significance Single submitter
- ARHGAP36 p.Phe28Leu Uncertain significance Single submitter
- ARHGAP36 p.Ser56Cys Uncertain significance Single submitter
- ARHGAP36 p.Thr136Met Uncertain significance Single submitter
- ARHGAP36 p.Thr540Ala Uncertain significance Single submitter
- ARHGAP36 p.Val188Met Uncertain significance Single submitter
- ARHGAP36 p.Val263Met Uncertain significance Single submitter
- ARHGAP36 p.Val32Ala Uncertain significance Single submitter
- ARHGAP36 p.Val486Ile Uncertain significance Single submitter
- ARHGAP36 p.Val542Ala Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- ARHGAP36 p.Lys295Arg Uncertain significance Multiple submitters
- ARHGAP36 p.Ala11Glu Uncertain significance Single submitter
- ARHGAP36 p.Ala484Val Uncertain significance Single submitter
- ARHGAP36 p.Arg149His Uncertain significance Single submitter
- ARHGAP36 p.Arg163Gln Uncertain significance Single submitter
- ARHGAP36 p.Arg299His Uncertain significance Single submitter
- ARHGAP36 p.Arg527Cys Likely benign Single submitter
- ARHGAP36 p.Arg534Trp Uncertain significance Single submitter
- ARHGAP36 p.Arg90Cys Uncertain significance Single submitter
- ARHGAP36 p.Gly183Trp Uncertain significance Single submitter
- ARHGAP36 p.Gly276Asp Uncertain significance Single submitter
- ARHGAP36 p.Leu388Val Uncertain significance Single submitter
- ARHGAP36 p.Lys438Asn Uncertain significance Single submitter
- ARHGAP36 p.Met301Ile Uncertain significance Single submitter
- ARHGAP36 p.Pro429Ala Uncertain significance Single submitter
- ARHGAP36 p.Thr47Met Uncertain significance Single submitter
- ARHGAP36 p.Val239Ile Uncertain significance Single submitter
All ARHGAP36 variants
Likely benign 5
- p.Arg439= Single submitter
- p.Arg527Cys Single submitter ⚠
- p.Gly394Ala Single submitter
- p.Pro523Leu Single submitter
- p.Val542Ile Single submitter
Uncertain significance 53
- p.Lys295Arg Multiple submitters ⚠
- p.Ala11Glu Single submitter ⚠
- p.Ala13Val Single submitter ⚠
- p.Ala200Asp Single submitter ⚠
- p.Ala200Val Single submitter ⚠
- p.Ala38Pro Single submitter ⚠
- p.Ala417Val Single submitter ⚠
- p.Ala484Val Single submitter ⚠
- p.Ala485Ser Single submitter ⚠
- p.Ala517Val Single submitter ⚠
- p.Ala538Thr Single submitter ⚠
- p.Arg12Ser Single submitter ⚠
- p.Arg149His Single submitter ⚠
- p.Arg156Gly Single submitter ⚠
- p.Arg163Gln Single submitter ⚠
- p.Arg299His Single submitter ⚠
- p.Arg416His Single submitter ⚠
- p.Arg45Leu Single submitter ⚠
- p.Arg45Ser Single submitter ⚠
- p.Arg527Ser Single submitter ⚠
- p.Arg531His Single submitter ⚠
- p.Arg534Leu Single submitter ⚠
- p.Arg534Trp Single submitter ⚠
- p.Arg90Cys Single submitter ⚠
- p.Asn42Lys Single submitter ⚠
- p.Asp95Asn Single submitter ⚠
- p.Glu119Lys Single submitter ⚠
- p.Glu500Gln Single submitter ⚠
- p.Gly183Trp Single submitter ⚠
- p.Gly255Arg Single submitter ⚠
- p.Gly276Asp Single submitter ⚠
- p.His352Arg Single submitter ⚠
- p.Ile215Thr Single submitter ⚠
- p.Leu381Val Single submitter ⚠
- p.Leu388Val Single submitter ⚠
- p.Leu77Phe Single submitter ⚠
- p.Lys223Glu Single submitter ⚠
- p.Lys438Asn Single submitter ⚠
- p.Lys96Asn Single submitter ⚠
- p.Lys9Arg Single submitter ⚠
- p.Met301Ile Single submitter ⚠
- p.Phe28Leu Single submitter ⚠
- p.Pro429Ala Single submitter ⚠
- p.Ser56Cys Single submitter ⚠
- p.Thr136Met Single submitter ⚠
- p.Thr47Met Single submitter ⚠
- p.Thr540Ala Single submitter ⚠
- p.Val188Met Single submitter ⚠
- p.Val239Ile Single submitter ⚠
- p.Val263Met Single submitter ⚠
- p.Val32Ala Single submitter ⚠
- p.Val486Ile Single submitter ⚠
- p.Val542Ala Single submitter ⚠