ARHGAP39 — 200 ClinVar variants
All ClinVar germline ARHGAP39 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 185 flagged for review →
2 Benign · 12 Likely benign · 186 Uncertain significance
Full ARHGAP39 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 185
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 113
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP39 p.Ala1056Val Uncertain significance Single submitter
- ARHGAP39 p.Ala120Val Uncertain significance Single submitter
- ARHGAP39 p.Ala322Thr Uncertain significance Single submitter
- ARHGAP39 p.Ala412Pro Uncertain significance Single submitter
- ARHGAP39 p.Ala412Thr Uncertain significance Single submitter
- ARHGAP39 p.Ala419Pro Uncertain significance Single submitter
- ARHGAP39 p.Ala468Thr Uncertain significance Single submitter
- ARHGAP39 p.Ala549Thr Uncertain significance Single submitter
- ARHGAP39 p.Ala922Thr Uncertain significance Single submitter
- ARHGAP39 p.Arg1078His Uncertain significance Single submitter
- ARHGAP39 p.Arg132Leu Uncertain significance Single submitter
- ARHGAP39 p.Arg155Thr Uncertain significance Single submitter
- ARHGAP39 p.Arg187Gln Uncertain significance Single submitter
- ARHGAP39 p.Arg241Gly Uncertain significance Single submitter
- ARHGAP39 p.Arg241His Uncertain significance Single submitter
- ARHGAP39 p.Arg243His Uncertain significance Single submitter
- ARHGAP39 p.Arg244Gly Uncertain significance Single submitter
- ARHGAP39 p.Arg347Gln Uncertain significance Single submitter
- ARHGAP39 p.Arg351His Uncertain significance Single submitter
- ARHGAP39 p.Arg354Gly Uncertain significance Single submitter
- ARHGAP39 p.Arg381Gly Uncertain significance Single submitter
- ARHGAP39 p.Arg396Gln Uncertain significance Single submitter
- ARHGAP39 p.Arg396Trp Uncertain significance Single submitter
- ARHGAP39 p.Arg411Leu Uncertain significance Single submitter
- ARHGAP39 p.Arg415Gln Uncertain significance Single submitter
- ARHGAP39 p.Arg41His Uncertain significance Single submitter
- ARHGAP39 p.Arg492His Uncertain significance Single submitter
- ARHGAP39 p.Arg538Gln Uncertain significance Single submitter
- ARHGAP39 p.Arg670His Uncertain significance Single submitter
- ARHGAP39 p.Arg711Trp Uncertain significance Single submitter
- ARHGAP39 p.Arg737Trp Uncertain significance Single submitter
- ARHGAP39 p.Arg781Gln Uncertain significance Single submitter
- ARHGAP39 p.Arg907Gln Uncertain significance Single submitter
- ARHGAP39 p.Arg937His Uncertain significance Single submitter
- ARHGAP39 p.Asp15His Uncertain significance Single submitter
- ARHGAP39 p.Asp438Tyr Uncertain significance Single submitter
- ARHGAP39 p.Cys9Arg Uncertain significance Single submitter
- ARHGAP39 p.Gln403Arg Uncertain significance Single submitter
- ARHGAP39 p.Gln478Lys Uncertain significance Single submitter
- ARHGAP39 p.Gln479Arg Uncertain significance Single submitter
- ARHGAP39 p.Gln629Arg Uncertain significance Single submitter
- ARHGAP39 p.Gln662Arg Uncertain significance Single submitter
- ARHGAP39 p.Gln668His Uncertain significance Single submitter
- ARHGAP39 p.Gln887Pro Uncertain significance Single submitter
- ARHGAP39 p.Glu184Asp Uncertain significance Single submitter
- ARHGAP39 p.Glu380Gly Uncertain significance Single submitter
- ARHGAP39 p.Glu470Gly Uncertain significance Single submitter
- ARHGAP39 p.Glu519Lys Uncertain significance Single submitter
- ARHGAP39 p.Glu664Lys Uncertain significance Single submitter
- ARHGAP39 p.Glu794Lys Uncertain significance Single submitter
- ARHGAP39 p.Glu8Lys Uncertain significance Single submitter
- ARHGAP39 p.Gly170Ser Uncertain significance Single submitter
- ARHGAP39 p.Gly263Ser Uncertain significance Single submitter
- ARHGAP39 p.Gly339Ala Uncertain significance Single submitter
- ARHGAP39 p.Gly405Asp Uncertain significance Single submitter
- ARHGAP39 p.Gly425Ser Uncertain significance Single submitter
- ARHGAP39 p.Gly512Ser Uncertain significance Single submitter
- ARHGAP39 p.Gly545Glu Uncertain significance Single submitter
- ARHGAP39 p.Gly548Ser Uncertain significance Single submitter
- ARHGAP39 p.Gly620Ser Uncertain significance Single submitter
- ARHGAP39 p.Gly672Ser Uncertain significance Single submitter
- ARHGAP39 p.Gly893Arg Uncertain significance Single submitter
- ARHGAP39 p.His738Asn Uncertain significance Single submitter
- ARHGAP39 p.Leu1077Phe Uncertain significance Single submitter
- ARHGAP39 p.Leu533Pro Uncertain significance Single submitter
- ARHGAP39 p.Lys181Glu Uncertain significance Single submitter
- ARHGAP39 p.Lys377Asn Uncertain significance Single submitter
- ARHGAP39 p.Lys377Thr Uncertain significance Single submitter
- ARHGAP39 p.Lys571Met Uncertain significance Single submitter
- ARHGAP39 p.Lys700Arg Uncertain significance Single submitter
- ARHGAP39 p.Lys880Asn Uncertain significance Single submitter
- ARHGAP39 p.Lys895Arg Uncertain significance Single submitter
- ARHGAP39 p.Met754Thr Uncertain significance Single submitter
- ARHGAP39 p.Met929Val Uncertain significance Single submitter
- ARHGAP39 p.Phe1013Tyr Uncertain significance Single submitter
- ARHGAP39 p.Phe266Ile Uncertain significance Single submitter
- ARHGAP39 p.Phe796Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro153Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro17Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro259Arg Uncertain significance Single submitter
- ARHGAP39 p.Pro292Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro304Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro310Arg Uncertain significance Single submitter
- ARHGAP39 p.Pro345Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro353Ser Uncertain significance Single submitter
- ARHGAP39 p.Pro364Thr Uncertain significance Single submitter
- ARHGAP39 p.Pro365Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro454Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro513Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro527Ser Uncertain significance Single submitter
- ARHGAP39 p.Pro592Ser Uncertain significance Single submitter
- ARHGAP39 p.Ser11Asn Uncertain significance Single submitter
- ARHGAP39 p.Ser128Gly Uncertain significance Single submitter
- ARHGAP39 p.Ser19Leu Uncertain significance Single submitter
- ARHGAP39 p.Ser445Phe Uncertain significance Single submitter
- ARHGAP39 p.Ser476Ala Uncertain significance Single submitter
- ARHGAP39 p.Ser671Arg Uncertain significance Single submitter
- ARHGAP39 p.Ser671Gly Uncertain significance Single submitter
- ARHGAP39 p.Ser735Arg Uncertain significance Single submitter
- ARHGAP39 p.Thr491Arg Uncertain significance Single submitter
- ARHGAP39 p.Thr4Arg Uncertain significance Single submitter
- ARHGAP39 p.Thr682Ile Uncertain significance Single submitter
- ARHGAP39 p.Thr692Met Uncertain significance Single submitter
- ARHGAP39 p.Tyr186His Uncertain significance Single submitter
- ARHGAP39 p.Tyr648Cys Uncertain significance Single submitter
- ARHGAP39 p.Val1086Ile Uncertain significance Single submitter
- ARHGAP39 p.Val130Gly Uncertain significance Single submitter
- ARHGAP39 p.Val240Asp Uncertain significance Single submitter
- ARHGAP39 p.Val332Ala Uncertain significance Single submitter
- ARHGAP39 p.Val372Leu Uncertain significance Single submitter
- ARHGAP39 p.Val443Ala Uncertain significance Single submitter
- ARHGAP39 p.Val777Met Uncertain significance Single submitter
- ARHGAP39 p.Cys434Phe Uncertain significance No assertion criteria
Predictors split 72
The independent predictors disagree with each other — read with care.
- ARHGAP39 p.Ala1033Val Uncertain significance Single submitter
- ARHGAP39 p.Ala322Asp Uncertain significance Single submitter
- ARHGAP39 p.Ala44Thr Uncertain significance Single submitter
- ARHGAP39 p.Ala549Val Uncertain significance Single submitter
- ARHGAP39 p.Arg1039His Uncertain significance Single submitter
- ARHGAP39 p.Arg1047His Uncertain significance Single submitter
- ARHGAP39 p.Arg132His Uncertain significance Single submitter
- ARHGAP39 p.Arg158Trp Uncertain significance Single submitter
- ARHGAP39 p.Arg241Cys Uncertain significance Single submitter
- ARHGAP39 p.Arg305His Uncertain significance Single submitter
- ARHGAP39 p.Arg305Ser Uncertain significance Single submitter
- ARHGAP39 p.Arg411Cys Uncertain significance Single submitter
- ARHGAP39 p.Arg558Trp Uncertain significance Single submitter
- ARHGAP39 p.Arg712Gln Uncertain significance Single submitter
- ARHGAP39 p.Arg737Gln Uncertain significance Single submitter
- ARHGAP39 p.Arg758Gln Uncertain significance Single submitter
- ARHGAP39 p.Arg803Leu Uncertain significance Single submitter
- ARHGAP39 p.Arg907Trp Uncertain significance Single submitter
- ARHGAP39 p.Arg933Cys Uncertain significance Single submitter
- ARHGAP39 p.Arg933His Uncertain significance Single submitter
- ARHGAP39 p.Asn837Ser Uncertain significance Single submitter
- ARHGAP39 p.Asn84Ser Likely benign Single submitter
- ARHGAP39 p.Asp762Asn Uncertain significance Single submitter
- ARHGAP39 p.Cys1043Ser Uncertain significance Single submitter
- ARHGAP39 p.Cys678Arg Uncertain significance Single submitter
- ARHGAP39 p.Glu1015Lys Uncertain significance Single submitter
- ARHGAP39 p.Glu211Lys Uncertain significance Single submitter
- ARHGAP39 p.Glu402Gly Uncertain significance Single submitter
- ARHGAP39 p.Glu50Asp Uncertain significance Single submitter
- ARHGAP39 p.Glu932Ala Uncertain significance Single submitter
- ARHGAP39 p.Gly193Asp Uncertain significance Single submitter
- ARHGAP39 p.Gly391Ala Uncertain significance Single submitter
- ARHGAP39 p.Gly779Ala Uncertain significance Single submitter
- ARHGAP39 p.Ile215Thr Uncertain significance Single submitter
- ARHGAP39 p.Leu533Phe Uncertain significance Single submitter
- ARHGAP39 p.Lys417Asn Uncertain significance Single submitter
- ARHGAP39 p.Lys62Arg Uncertain significance Single submitter
- ARHGAP39 p.Met213Ile Uncertain significance Single submitter
- ARHGAP39 p.Phe627Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro272Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro287Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro310Thr Uncertain significance Single submitter
- ARHGAP39 p.Pro311Ala Uncertain significance Single submitter
- ARHGAP39 p.Pro349Gln Uncertain significance Single submitter
- ARHGAP39 p.Pro349Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro365Thr Uncertain significance Single submitter
- ARHGAP39 p.Pro461Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro489Leu Uncertain significance Single submitter
- ARHGAP39 p.Pro598Arg Uncertain significance Single submitter
- ARHGAP39 p.Pro628Arg Uncertain significance Single submitter
- ARHGAP39 p.Ser248Thr Uncertain significance Single submitter
- ARHGAP39 p.Ser285Thr Uncertain significance Single submitter
- ARHGAP39 p.Ser344Phe Uncertain significance Single submitter
- ARHGAP39 p.Ser384Ile Uncertain significance Single submitter
- ARHGAP39 p.Ser484Phe Uncertain significance Single submitter
- ARHGAP39 p.Ser488Phe Uncertain significance Single submitter
- ARHGAP39 p.Ser677Asn Uncertain significance Single submitter
- ARHGAP39 p.Ser735Asn Uncertain significance Single submitter
- ARHGAP39 p.Thr463Met Uncertain significance Single submitter
- ARHGAP39 p.Thr48Ser Uncertain significance Single submitter
- ARHGAP39 p.Trp475Arg Uncertain significance Single submitter
- ARHGAP39 p.Tyr883Cys Uncertain significance Single submitter
- ARHGAP39 p.Val1028Ala Uncertain significance Single submitter
- ARHGAP39 p.Val1060Ala Uncertain significance Single submitter
- ARHGAP39 p.Val395Met Uncertain significance Single submitter
- ARHGAP39 p.Val600Met Uncertain significance Single submitter
- ARHGAP39 p.Val638Met Uncertain significance Single submitter
- ARHGAP39 p.Val733Met Uncertain significance Single submitter
- ARHGAP39 p.Val903Met Uncertain significance Single submitter
- ARHGAP39 p.Val913Met Uncertain significance Single submitter
- ARHGAP39 p.Val942Leu Uncertain significance Single submitter
- ARHGAP39 p.Val992Ile Uncertain significance Single submitter
All ARHGAP39 variants
Likely benign 12
- p.Ala191Val Single submitter
- p.Ala258Thr Single submitter
- p.Arg27= Single submitter
- p.Arg963= Single submitter
- p.Asn84Ser Single submitter ⚠
- p.Gln503His Single submitter
- p.Gly236Ser Single submitter
- p.Lys444Arg Single submitter
- p.Ser19= Single submitter
- p.Thr164Ala Single submitter
- p.Thr853Ser Single submitter
- p.Val673Ile Single submitter
Uncertain significance 186
- p.Ala1033Val Single submitter ⚠
- p.Ala1056Val Single submitter ⚠
- p.Ala120Val Single submitter ⚠
- p.Ala322Asp Single submitter ⚠
- p.Ala322Thr Single submitter ⚠
- p.Ala412Pro Single submitter ⚠
- p.Ala412Thr Single submitter ⚠
- p.Ala419Pro Single submitter ⚠
- p.Ala44Thr Single submitter ⚠
- p.Ala468Thr Single submitter ⚠
- p.Ala549Thr Single submitter ⚠
- p.Ala549Val Single submitter ⚠
- p.Ala922Thr Single submitter ⚠
- p.Arg1039His Single submitter ⚠
- p.Arg1047His Single submitter ⚠
- p.Arg1078His Single submitter ⚠
- p.Arg132His Single submitter ⚠
- p.Arg132Leu Single submitter ⚠
- p.Arg155Thr Single submitter ⚠
- p.Arg158Trp Single submitter ⚠
- p.Arg187Gln Single submitter ⚠
- p.Arg241Cys Single submitter ⚠
- p.Arg241Gly Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg243His Single submitter ⚠
- p.Arg244Gly Single submitter ⚠
- p.Arg305His Single submitter ⚠
- p.Arg305Ser Single submitter ⚠
- p.Arg347Gln Single submitter ⚠
- p.Arg351His Single submitter ⚠
- p.Arg354Gly Single submitter ⚠
- p.Arg381Gly Single submitter ⚠
- p.Arg396Gln Single submitter ⚠
- p.Arg396Trp Single submitter ⚠
- p.Arg411Cys Single submitter ⚠
- p.Arg411Leu Single submitter ⚠
- p.Arg415Gln Single submitter ⚠
- p.Arg41His Single submitter ⚠
- p.Arg492His Single submitter ⚠
- p.Arg538Gln Single submitter ⚠
- p.Arg558Trp Single submitter ⚠
- p.Arg670His Single submitter ⚠
- p.Arg711Trp Single submitter ⚠
- p.Arg712Gln Single submitter ⚠
- p.Arg737Gln Single submitter ⚠
- p.Arg737Trp Single submitter ⚠
- p.Arg758Gln Single submitter ⚠
- p.Arg781Gln Single submitter ⚠
- p.Arg803Leu Single submitter ⚠
- p.Arg907Gln Single submitter ⚠
- p.Arg907Trp Single submitter ⚠
- p.Arg933Cys Single submitter ⚠
- p.Arg933His Single submitter ⚠
- p.Arg937His Single submitter ⚠
- p.Asn837Ser Single submitter ⚠
- p.Asp15His Single submitter ⚠
- p.Asp438Tyr Single submitter ⚠
- p.Asp762Asn Single submitter ⚠
- p.Cys1043Ser Single submitter ⚠
- p.Cys678Arg Single submitter ⚠
- p.Cys9Arg Single submitter ⚠
- p.Gln403Arg Single submitter ⚠
- p.Gln478Lys Single submitter ⚠
- p.Gln479Arg Single submitter ⚠
- p.Gln629Arg Single submitter ⚠
- p.Gln662Arg Single submitter ⚠
- p.Gln668His Single submitter ⚠
- p.Gln887Pro Single submitter ⚠
- p.Glu1015Lys Single submitter ⚠
- p.Glu184Asp Single submitter ⚠
- p.Glu211Lys Single submitter ⚠
- p.Glu380Gly Single submitter ⚠
- p.Glu402Gly Single submitter ⚠
- p.Glu470Gly Single submitter ⚠
- p.Glu50Asp Single submitter ⚠
- p.Glu519Lys Single submitter ⚠
- p.Glu664Lys Single submitter ⚠
- p.Glu794Lys Single submitter ⚠
- p.Glu8Lys Single submitter ⚠
- p.Glu932Ala Single submitter ⚠
- p.Gly170Ser Single submitter ⚠
- p.Gly193Asp Single submitter ⚠
- p.Gly263Ser Single submitter ⚠
- p.Gly339Ala Single submitter ⚠
- p.Gly391Ala Single submitter ⚠
- p.Gly405Asp Single submitter ⚠
- p.Gly425Ser Single submitter ⚠
- p.Gly512Ser Single submitter ⚠
- p.Gly545Glu Single submitter ⚠
- p.Gly548Ser Single submitter ⚠
- p.Gly620Ser Single submitter ⚠
- p.Gly672Ser Single submitter ⚠
- p.Gly779Ala Single submitter ⚠
- p.Gly893Arg Single submitter ⚠
- p.His738Asn Single submitter ⚠
- p.Ile215Thr Single submitter ⚠
- p.Leu1077Phe Single submitter ⚠
- p.Leu533Phe Single submitter ⚠
- p.Leu533Pro Single submitter ⚠
- p.Lys181Glu Single submitter ⚠
- p.Lys377Asn Single submitter ⚠
- p.Lys377Thr Single submitter ⚠
- p.Lys417Asn Single submitter ⚠
- p.Lys571Met Single submitter ⚠
- p.Lys62Arg Single submitter ⚠
- p.Lys700Arg Single submitter ⚠
- p.Lys880Asn Single submitter ⚠
- p.Lys895Arg Single submitter ⚠
- p.Met213Ile Single submitter ⚠
- p.Met754Thr Single submitter ⚠
- p.Met929Val Single submitter ⚠
- p.Phe1013Tyr Single submitter ⚠
- p.Phe266Ile Single submitter ⚠
- p.Phe627Leu Single submitter ⚠
- p.Phe796Leu Single submitter ⚠
- p.Pro153Leu Single submitter ⚠
- p.Pro17Leu Single submitter ⚠
- p.Pro259Arg Single submitter ⚠
- p.Pro272Leu Single submitter ⚠
- p.Pro287Leu Single submitter ⚠
- p.Pro292Leu Single submitter ⚠
- p.Pro304Leu Single submitter ⚠
- p.Pro310Arg Single submitter ⚠
- p.Pro310Thr Single submitter ⚠
- p.Pro311Ala Single submitter ⚠
- p.Pro345Leu Single submitter ⚠
- p.Pro349Gln Single submitter ⚠
- p.Pro349Leu Single submitter ⚠
- p.Pro353Ser Single submitter ⚠
- p.Pro364Thr Single submitter ⚠
- p.Pro365Leu Single submitter ⚠
- p.Pro365Thr Single submitter ⚠
- p.Pro454Leu Single submitter ⚠
- p.Pro461Leu Single submitter ⚠
- p.Pro489Leu Single submitter ⚠
- p.Pro513Leu Single submitter ⚠
- p.Pro527Ser Single submitter ⚠
- p.Pro592Ser Single submitter ⚠
- p.Pro598Arg Single submitter ⚠
- p.Pro628Arg Single submitter ⚠
- p.Pro870Leu Single submitter
- p.Ser11Asn Single submitter ⚠
- p.Ser128Gly Single submitter ⚠
- p.Ser19Leu Single submitter ⚠
- p.Ser248Thr Single submitter ⚠
- p.Ser285Thr Single submitter ⚠
- p.Ser344Phe Single submitter ⚠
- p.Ser384Ile Single submitter ⚠
- p.Ser445Phe Single submitter ⚠
- p.Ser476Ala Single submitter ⚠
- p.Ser484Phe Single submitter ⚠
- p.Ser488Phe Single submitter ⚠
- p.Ser671Arg Single submitter ⚠
- p.Ser671Gly Single submitter ⚠
- p.Ser677Asn Single submitter ⚠
- p.Ser735Arg Single submitter ⚠
- p.Ser735Asn Single submitter ⚠
- p.Thr463Met Single submitter ⚠
- p.Thr48Ser Single submitter ⚠
- p.Thr491Arg Single submitter ⚠
- p.Thr4Arg Single submitter ⚠
- p.Thr682Ile Single submitter ⚠
- p.Thr692Met Single submitter ⚠
- p.Trp475Arg Single submitter ⚠
- p.Tyr186His Single submitter ⚠
- p.Tyr648Cys Single submitter ⚠
- p.Tyr866Cys Single submitter
- p.Tyr883Cys Single submitter ⚠
- p.Val1028Ala Single submitter ⚠
- p.Val1060Ala Single submitter ⚠
- p.Val1086Ile Single submitter ⚠
- p.Val130Gly Single submitter ⚠
- p.Val240Asp Single submitter ⚠
- p.Val332Ala Single submitter ⚠
- p.Val372Leu Single submitter ⚠
- p.Val395Met Single submitter ⚠
- p.Val443Ala Single submitter ⚠
- p.Val600Met Single submitter ⚠
- p.Val638Met Single submitter ⚠
- p.Val733Met Single submitter ⚠
- p.Val777Met Single submitter ⚠
- p.Val903Met Single submitter ⚠
- p.Val913Met Single submitter ⚠
- p.Val942Leu Single submitter ⚠
- p.Val992Ile Single submitter ⚠
- p.Cys434Phe No assertion criteria ⚠