ARHGAP8 — 86 ClinVar variants
All ClinVar germline ARHGAP8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
3 Benign · 12 Likely benign · 71 Uncertain significance
Full ARHGAP8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP8 p.Ala362Thr Uncertain significance Single submitter
- ARHGAP8 p.Ala386Val Uncertain significance Single submitter
- ARHGAP8 p.Ala413Val Uncertain significance Single submitter
- ARHGAP8 p.Arg185Gln Uncertain significance Single submitter
- ARHGAP8 p.Arg432Pro Uncertain significance Single submitter
- ARHGAP8 p.Asp164Glu Uncertain significance Single submitter
- ARHGAP8 p.Glu385Gln Uncertain significance Single submitter
- ARHGAP8 p.Glu406Lys Uncertain significance Single submitter
- ARHGAP8 p.Gly259Arg Uncertain significance Single submitter
- ARHGAP8 p.Gly347Arg Uncertain significance Single submitter
- ARHGAP8 p.Ile156Thr Uncertain significance Single submitter
- ARHGAP8 p.Ile333Val Uncertain significance Single submitter
- ARHGAP8 p.Leu230Pro Uncertain significance Single submitter
- ARHGAP8 p.Leu307Val Uncertain significance Single submitter
- ARHGAP8 p.Leu366Val Uncertain significance Single submitter
- ARHGAP8 p.Lys134Arg Uncertain significance Single submitter
- ARHGAP8 p.Met337Ile Uncertain significance Single submitter
- ARHGAP8 p.Met368Val Uncertain significance Single submitter
- ARHGAP8 p.Phe215Ile Uncertain significance Single submitter
- ARHGAP8 p.Pro419Leu Uncertain significance Single submitter
- ARHGAP8 p.Pro423Leu Uncertain significance Single submitter
- ARHGAP8 p.Pro425Ala Uncertain significance Single submitter
- ARHGAP8 p.Ser354Ala Uncertain significance Single submitter
- ARHGAP8 p.Ser358Ala Uncertain significance Single submitter
- ARHGAP8 p.Thr414Met Uncertain significance Single submitter
- ARHGAP8 p.Thr420Pro Uncertain significance Single submitter
Predictors split 50
The independent predictors disagree with each other — read with care.
- ARHGAP8 p.Ala235Thr Uncertain significance Single submitter
- ARHGAP8 p.Arg162Gly Uncertain significance Single submitter
- ARHGAP8 p.Arg241His Uncertain significance Single submitter
- ARHGAP8 p.Arg304Cys Uncertain significance Single submitter
- ARHGAP8 p.Arg304His Uncertain significance Single submitter
- ARHGAP8 p.Arg30Gly Uncertain significance Single submitter
- ARHGAP8 p.Arg319Cys Likely benign Single submitter
- ARHGAP8 p.Arg319His Uncertain significance Single submitter
- ARHGAP8 p.Arg319Leu Benign Single submitter
- ARHGAP8 p.Arg330Trp Uncertain significance Single submitter
- ARHGAP8 p.Arg34His Uncertain significance Single submitter
- ARHGAP8 p.Asn204Asp Uncertain significance Single submitter
- ARHGAP8 p.Asn349His Uncertain significance Single submitter
- ARHGAP8 p.Asp257Asn Uncertain significance Single submitter
- ARHGAP8 p.Asp50Glu Uncertain significance Single submitter
- ARHGAP8 p.Asp69Asn Uncertain significance Single submitter
- ARHGAP8 p.Asp98His Uncertain significance Single submitter
- ARHGAP8 p.Cys303Gly Uncertain significance Single submitter
- ARHGAP8 p.Gln277Pro Uncertain significance Single submitter
- ARHGAP8 p.Glu147Lys Uncertain significance Single submitter
- ARHGAP8 p.Glu207Lys Uncertain significance Single submitter
- ARHGAP8 p.Glu371Gln Likely benign Single submitter
- ARHGAP8 p.Gly21Asp Uncertain significance Single submitter
- ARHGAP8 p.Ile306Asn Uncertain significance Single submitter
- ARHGAP8 p.Ile374Met Uncertain significance Single submitter
- ARHGAP8 p.Leu363Arg Uncertain significance Single submitter
- ARHGAP8 p.Leu433Phe Uncertain significance Single submitter
- ARHGAP8 p.Phe255Val Uncertain significance Single submitter
- ARHGAP8 p.Pro178Leu Uncertain significance Single submitter
- ARHGAP8 p.Pro184Leu Uncertain significance Single submitter
- ARHGAP8 p.Pro211Ser Uncertain significance Single submitter
- ARHGAP8 p.Pro365Arg Uncertain significance Single submitter
- ARHGAP8 p.Pro384Ala Uncertain significance Single submitter
- ARHGAP8 p.Pro387Leu Uncertain significance Single submitter
- ARHGAP8 p.Pro45Ala Uncertain significance Single submitter
- ARHGAP8 p.Ser143Arg Uncertain significance Single submitter
- ARHGAP8 p.Ser296Arg Likely benign Single submitter
- ARHGAP8 p.Ser340Phe Uncertain significance Single submitter
- ARHGAP8 p.Ser354Cys Uncertain significance Single submitter
- ARHGAP8 p.Ser361Arg Uncertain significance Single submitter
- ARHGAP8 p.Thr61Ile Uncertain significance Single submitter
- ARHGAP8 p.Tyr138Cys Uncertain significance Single submitter
- ARHGAP8 p.Tyr320Cys Uncertain significance Single submitter
- ARHGAP8 p.Tyr377Cys Uncertain significance Single submitter
- ARHGAP8 p.Val17Met Uncertain significance Single submitter
- ARHGAP8 p.Val195Ile Uncertain significance Single submitter
- ARHGAP8 p.Val300Leu Uncertain significance Single submitter
- ARHGAP8 p.Val316Ile Uncertain significance Single submitter
- ARHGAP8 p.Val317Ile Likely benign Single submitter
- ARHGAP8 p.Val35Ala Uncertain significance Single submitter
All ARHGAP8 variants
Benign 3
- p.Ile374= Multiple submitters
- p.Pro176Leu Multiple submitters
- p.Arg319Leu Single submitter ⚠
Likely benign 12
- c.299+658C>T Single submitter
- p.Arg319Cys Single submitter ⚠
- p.Gln412Arg Single submitter
- p.Glu371Gln Single submitter ⚠
- p.Glu378= Single submitter
- p.Lys418Thr Single submitter
- p.Pro6= Single submitter
- p.Ser296Arg Single submitter ⚠
- p.Ser329= Single submitter
- p.Val240Ile Single submitter
- p.Val317Ile Single submitter ⚠
- c.299+648A>G No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 71
- p.Ala235Thr Single submitter ⚠
- p.Ala362Thr Single submitter ⚠
- p.Ala386Val Single submitter ⚠
- p.Ala413Val Single submitter ⚠
- p.Arg162Gly Single submitter ⚠
- p.Arg185Gln Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg304Cys Single submitter ⚠
- p.Arg304His Single submitter ⚠
- p.Arg30Gly Single submitter ⚠
- p.Arg319His Single submitter ⚠
- p.Arg330Trp Single submitter ⚠
- p.Arg34His Single submitter ⚠
- p.Arg432Pro Single submitter ⚠
- p.Asn204Asp Single submitter ⚠
- p.Asn349His Single submitter ⚠
- p.Asp164Glu Single submitter ⚠
- p.Asp257Asn Single submitter ⚠
- p.Asp50Glu Single submitter ⚠
- p.Asp69Asn Single submitter ⚠
- p.Asp98His Single submitter ⚠
- p.Cys303Gly Single submitter ⚠
- p.Gln277Pro Single submitter ⚠
- p.Glu147Lys Single submitter ⚠
- p.Glu207Lys Single submitter ⚠
- p.Glu385Gln Single submitter ⚠
- p.Glu406Lys Single submitter ⚠
- p.Gly21Asp Single submitter ⚠
- p.Gly259Arg Single submitter ⚠
- p.Gly347Arg Single submitter ⚠
- p.Ile156Thr Single submitter ⚠
- p.Ile306Asn Single submitter ⚠
- p.Ile333Val Single submitter ⚠
- p.Ile374Met Single submitter ⚠
- p.Leu230Pro Single submitter ⚠
- p.Leu307Val Single submitter ⚠
- p.Leu363Arg Single submitter ⚠
- p.Leu366Val Single submitter ⚠
- p.Leu433Phe Single submitter ⚠
- p.Lys134Arg Single submitter ⚠
- p.Met337Ile Single submitter ⚠
- p.Met368Val Single submitter ⚠
- p.Phe215Ile Single submitter ⚠
- p.Phe255Val Single submitter ⚠
- p.Pro178Leu Single submitter ⚠
- p.Pro184Leu Single submitter ⚠
- p.Pro211Ser Single submitter ⚠
- p.Pro365Arg Single submitter ⚠
- p.Pro384Ala Single submitter ⚠
- p.Pro387Leu Single submitter ⚠
- p.Pro419Leu Single submitter ⚠
- p.Pro423Leu Single submitter ⚠
- p.Pro425Ala Single submitter ⚠
- p.Pro45Ala Single submitter ⚠
- p.Ser143Arg Single submitter ⚠
- p.Ser340Phe Single submitter ⚠
- p.Ser354Ala Single submitter ⚠
- p.Ser354Cys Single submitter ⚠
- p.Ser358Ala Single submitter ⚠
- p.Ser361Arg Single submitter ⚠
- p.Thr414Met Single submitter ⚠
- p.Thr420Pro Single submitter ⚠
- p.Thr61Ile Single submitter ⚠
- p.Tyr138Cys Single submitter ⚠
- p.Tyr320Cys Single submitter ⚠
- p.Tyr377Cys Single submitter ⚠
- p.Val17Met Single submitter ⚠
- p.Val195Ile Single submitter ⚠
- p.Val300Leu Single submitter ⚠
- p.Val316Ile Single submitter ⚠
- p.Val35Ala Single submitter ⚠