ARHGAP9 — 77 ClinVar variants
All ClinVar germline ARHGAP9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Benign · 6 Likely benign · 70 Uncertain significance
Full ARHGAP9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGAP9 p.Ala127Pro Uncertain significance Single submitter
- ARHGAP9 p.Ala29Asp Uncertain significance Single submitter
- ARHGAP9 p.Ala306Asp Uncertain significance Single submitter
- ARHGAP9 p.Arg198Cys Uncertain significance Single submitter
- ARHGAP9 p.Arg202Gln Uncertain significance Single submitter
- ARHGAP9 p.Arg202Trp Uncertain significance Single submitter
- ARHGAP9 p.Arg249Ser Uncertain significance Single submitter
- ARHGAP9 p.Arg311Leu Uncertain significance Single submitter
- ARHGAP9 p.Arg559Trp Uncertain significance Single submitter
- ARHGAP9 p.Arg700Gln Uncertain significance Single submitter
- ARHGAP9 p.Asn344Asp Uncertain significance Single submitter
- ARHGAP9 p.Asp319Asn Uncertain significance Single submitter
- ARHGAP9 p.Asp606Gly Uncertain significance Single submitter
- ARHGAP9 p.Cys140Phe Uncertain significance Single submitter
- ARHGAP9 p.Gln511Arg Uncertain significance Single submitter
- ARHGAP9 p.Gln650His Uncertain significance Single submitter
- ARHGAP9 p.Glu251Val Uncertain significance Single submitter
- ARHGAP9 p.Glu380Lys Uncertain significance Single submitter
- ARHGAP9 p.Glu486Ala Uncertain significance Single submitter
- ARHGAP9 p.Glu702Gln Uncertain significance Single submitter
- ARHGAP9 p.Gly162Arg Uncertain significance Single submitter
- ARHGAP9 p.Gly255Asp Uncertain significance Single submitter
- ARHGAP9 p.Gly282Arg Uncertain significance Single submitter
- ARHGAP9 p.Gly393Ser Uncertain significance Single submitter
- ARHGAP9 p.His111Arg Uncertain significance Single submitter
- ARHGAP9 p.Ile677Thr Uncertain significance Single submitter
- ARHGAP9 p.Ile76Val Uncertain significance Single submitter
- ARHGAP9 p.Leu302Ile Uncertain significance Single submitter
- ARHGAP9 p.Leu528His Uncertain significance Single submitter
- ARHGAP9 p.Leu542Phe Uncertain significance Single submitter
- ARHGAP9 p.Lys333Asn Uncertain significance Single submitter
- ARHGAP9 p.Pro107Leu Uncertain significance Single submitter
- ARHGAP9 p.Pro188Thr Uncertain significance Single submitter
- ARHGAP9 p.Pro245Arg Uncertain significance Single submitter
- ARHGAP9 p.Pro245Leu Uncertain significance Single submitter
- ARHGAP9 p.Pro254Thr Uncertain significance Single submitter
- ARHGAP9 p.Pro304Ala Uncertain significance Single submitter
- ARHGAP9 p.Pro314Arg Uncertain significance Single submitter
- ARHGAP9 p.Pro314Leu Uncertain significance Single submitter
- ARHGAP9 p.Pro471Arg Uncertain significance Single submitter
- ARHGAP9 p.Pro485Leu Uncertain significance Single submitter
- ARHGAP9 p.Pro629Arg Uncertain significance Single submitter
- ARHGAP9 p.Pro731Arg Uncertain significance Single submitter
- ARHGAP9 p.Ser326Leu Uncertain significance Single submitter
- ARHGAP9 p.Ser642Ala Uncertain significance Single submitter
- ARHGAP9 p.Ser644Leu Uncertain significance Single submitter
- ARHGAP9 p.Ser92Arg Uncertain significance Single submitter
- ARHGAP9 p.Thr281Pro Uncertain significance Single submitter
- ARHGAP9 p.Thr332Ser Uncertain significance Single submitter
- ARHGAP9 p.Thr57Asn Uncertain significance Single submitter
- ARHGAP9 p.Thr612Ile Uncertain significance Single submitter
- ARHGAP9 p.Thr697Asn Uncertain significance Single submitter
- ARHGAP9 p.Thr724Ile Uncertain significance Single submitter
- ARHGAP9 p.Tyr232Cys Uncertain significance Single submitter
- ARHGAP9 p.Tyr558Asn Uncertain significance Single submitter
- ARHGAP9 p.Val554Leu Uncertain significance Single submitter
- ARHGAP9 p.Val627Met Uncertain significance Single submitter
- ARHGAP9 p.Arg137Cys Uncertain significance No assertion criteria
-
ARHGAP9 p.Ser370Ala
Uncertain significance
No assertion criteria
Coronary artery spasm 3, susceptibility to
Predictors split 10
The independent predictors disagree with each other — read with care.
- ARHGAP9 p.Arg229His Uncertain significance Single submitter
- ARHGAP9 p.Arg578His Uncertain significance Single submitter
- ARHGAP9 p.Arg684Cys Uncertain significance Single submitter
- ARHGAP9 p.Asn725Ser Uncertain significance Single submitter
- ARHGAP9 p.Asp583Glu Uncertain significance Single submitter
- ARHGAP9 p.Leu729Val Uncertain significance Single submitter
- ARHGAP9 p.Pro136Thr Uncertain significance Single submitter
- ARHGAP9 p.Pro589Leu Uncertain significance Single submitter
- ARHGAP9 p.Ser356Ile Uncertain significance Single submitter
- ARHGAP9 p.Val493Ala Uncertain significance Single submitter
All ARHGAP9 variants
Benign 1
- p.Ala69= Multiple submitters
Likely benign 6
- c.1116+13G>C Single submitter
- c.317-15C>T Single submitter
- p.Arg675= Single submitter
- p.His663Arg Single submitter
- p.Met331Val Single submitter
- p.Pro171Leu Single submitter
Uncertain significance 70
- p.Ala127Pro Single submitter ⚠
- p.Ala29Asp Single submitter ⚠
- p.Ala306Asp Single submitter ⚠
- p.Arg198Cys Single submitter ⚠
- p.Arg202Gln Single submitter ⚠
- p.Arg202Trp Single submitter ⚠
- p.Arg229His Single submitter ⚠
- p.Arg249Ser Single submitter ⚠
- p.Arg311Leu Single submitter ⚠
- p.Arg361Leu Single submitter
- p.Arg559Trp Single submitter ⚠
- p.Arg578His Single submitter ⚠
- p.Arg684Cys Single submitter ⚠
- p.Arg700Gln Single submitter ⚠
- p.Asn344Asp Single submitter ⚠
- p.Asn725Ser Single submitter ⚠
- p.Asp319Asn Single submitter ⚠
- p.Asp583Glu Single submitter ⚠
- p.Asp606Gly Single submitter ⚠
- p.Cys140Phe Single submitter ⚠
- p.Gln511Arg Single submitter ⚠
- p.Gln650His Single submitter ⚠
- p.Glu251Val Single submitter ⚠
- p.Glu380Lys Single submitter ⚠
- p.Glu486Ala Single submitter ⚠
- p.Glu702Gln Single submitter ⚠
- p.Gly162Arg Single submitter ⚠
- p.Gly255Asp Single submitter ⚠
- p.Gly282Arg Single submitter ⚠
- p.Gly393Ser Single submitter ⚠
- p.His111Arg Single submitter ⚠
- p.Ile677Thr Single submitter ⚠
- p.Ile76Val Single submitter ⚠
- p.Leu302Ile Single submitter ⚠
- p.Leu528His Single submitter ⚠
- p.Leu542Phe Single submitter ⚠
- p.Leu729Val Single submitter ⚠
- p.Lys333Asn Single submitter ⚠
- p.Pro107Leu Single submitter ⚠
- p.Pro136Thr Single submitter ⚠
- p.Pro188Thr Single submitter ⚠
- p.Pro245Arg Single submitter ⚠
- p.Pro245Leu Single submitter ⚠
- p.Pro254Thr Single submitter ⚠
- p.Pro304Ala Single submitter ⚠
- p.Pro314Arg Single submitter ⚠
- p.Pro314Leu Single submitter ⚠
- p.Pro471Arg Single submitter ⚠
- p.Pro485Leu Single submitter ⚠
- p.Pro589Leu Single submitter ⚠
- p.Pro629Arg Single submitter ⚠
- p.Pro731Arg Single submitter ⚠
- p.Ser326Leu Single submitter ⚠
- p.Ser356Ile Single submitter ⚠
- p.Ser642Ala Single submitter ⚠
- p.Ser644Leu Single submitter ⚠
- p.Ser92Arg Single submitter ⚠
- p.Thr281Pro Single submitter ⚠
- p.Thr332Ser Single submitter ⚠
- p.Thr57Asn Single submitter ⚠
- p.Thr612Ile Single submitter ⚠
- p.Thr697Asn Single submitter ⚠
- p.Thr724Ile Single submitter ⚠
- p.Tyr232Cys Single submitter ⚠
- p.Tyr558Asn Single submitter ⚠
- p.Val493Ala Single submitter ⚠
- p.Val554Leu Single submitter ⚠
- p.Val627Met Single submitter ⚠
- p.Arg137Cys No assertion criteria ⚠
- p.Ser370Ala No assertion criteria Coronary artery spasm 3, susceptibility to ⚠