ARHGDIB — 22 ClinVar variants
All ClinVar germline ARHGDIB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
22 Uncertain significance
Full ARHGDIB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGDIB p.Arg149Gln Uncertain significance Single submitter
- ARHGDIB p.Arg149Trp Uncertain significance Single submitter
- ARHGDIB p.Asp118Gly Uncertain significance Single submitter
- ARHGDIB p.Asp181Asn Uncertain significance Single submitter
- ARHGDIB p.Leu22Pro Uncertain significance Single submitter
- ARHGDIB p.Leu32Met Uncertain significance Single submitter
- ARHGDIB p.Leu91Met Uncertain significance Single submitter
- ARHGDIB p.Pro26Ser Uncertain significance Single submitter
- ARHGDIB p.Thr140Ile Uncertain significance Single submitter
- ARHGDIB p.Thr157Ala Uncertain significance Single submitter
- ARHGDIB p.Thr179Ser Uncertain significance Single submitter
- ARHGDIB p.Val126Ile Uncertain significance Single submitter
- ARHGDIB p.Val143Ile Uncertain significance Single submitter
- ARHGDIB p.Val59Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ARHGDIB p.Asn116Lys Uncertain significance Single submitter
- ARHGDIB p.Gln36His Uncertain significance Single submitter
- ARHGDIB p.Glu3Gly Uncertain significance Single submitter
- ARHGDIB p.Glu43Asp Uncertain significance Single submitter
- ARHGDIB p.Lys135Thr Uncertain significance Single submitter
- ARHGDIB p.Pro26Thr Uncertain significance Single submitter
- ARHGDIB p.Pro80Leu Uncertain significance Single submitter
- ARHGDIB p.Val159Ala Uncertain significance Single submitter
All ARHGDIB variants
Uncertain significance 22
- p.Arg149Gln Single submitter ⚠
- p.Arg149Trp Single submitter ⚠
- p.Asn116Lys Single submitter ⚠
- p.Asp118Gly Single submitter ⚠
- p.Asp181Asn Single submitter ⚠
- p.Gln36His Single submitter ⚠
- p.Glu3Gly Single submitter ⚠
- p.Glu43Asp Single submitter ⚠
- p.Leu22Pro Single submitter ⚠
- p.Leu32Met Single submitter ⚠
- p.Leu91Met Single submitter ⚠
- p.Lys135Thr Single submitter ⚠
- p.Pro26Ser Single submitter ⚠
- p.Pro26Thr Single submitter ⚠
- p.Pro80Leu Single submitter ⚠
- p.Thr140Ile Single submitter ⚠
- p.Thr157Ala Single submitter ⚠
- p.Thr179Ser Single submitter ⚠
- p.Val126Ile Single submitter ⚠
- p.Val143Ile Single submitter ⚠
- p.Val159Ala Single submitter ⚠
- p.Val59Met Single submitter ⚠