ARHGEF11 — 175 ClinVar variants
All ClinVar germline ARHGEF11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 163 flagged for review →
1 Benign · 11 Likely benign · 163 Uncertain significance
Full ARHGEF11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 163
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 106
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGEF11 p.Ala1127Asp Uncertain significance Single submitter
- ARHGEF11 p.Ala1128Thr Uncertain significance Single submitter
- ARHGEF11 p.Ala113Thr Uncertain significance Single submitter
- ARHGEF11 p.Ala1143Thr Uncertain significance Single submitter
- ARHGEF11 p.Ala1485Thr Uncertain significance Single submitter
- ARHGEF11 p.Ala1547Gly Uncertain significance Single submitter
- ARHGEF11 p.Ala539Thr Uncertain significance Single submitter
- ARHGEF11 p.Ala683Val Uncertain significance Single submitter
- ARHGEF11 p.Ala988Thr Uncertain significance Single submitter
- ARHGEF11 p.Arg1119Gln Uncertain significance Single submitter
- ARHGEF11 p.Arg1178Lys Uncertain significance Single submitter
- ARHGEF11 p.Arg143Gln Uncertain significance Single submitter
- ARHGEF11 p.Arg1449Cys Uncertain significance Single submitter
- ARHGEF11 p.Arg1452His Uncertain significance Single submitter
- ARHGEF11 p.Arg1460Gly Uncertain significance Single submitter
- ARHGEF11 p.Arg46His Uncertain significance Single submitter
- ARHGEF11 p.Arg528Gln Uncertain significance Single submitter
- ARHGEF11 p.Arg644His Uncertain significance Single submitter
- ARHGEF11 p.Arg648Leu Uncertain significance Single submitter
- ARHGEF11 p.Arg817Gln Uncertain significance Single submitter
- ARHGEF11 p.Arg856Gln Uncertain significance Single submitter
- ARHGEF11 p.Arg888His Uncertain significance Single submitter
- ARHGEF11 p.Arg948Gln Uncertain significance Single submitter
- ARHGEF11 p.Arg950Trp Uncertain significance Single submitter
- ARHGEF11 p.Asn1444Lys Uncertain significance Single submitter
- ARHGEF11 p.Asn560Ser Uncertain significance Single submitter
- ARHGEF11 p.Asn604Ser Uncertain significance Single submitter
- ARHGEF11 p.Asp1239Glu Uncertain significance Single submitter
- ARHGEF11 p.Asp1445Asn Uncertain significance Single submitter
- ARHGEF11 p.Asp53Gly Uncertain significance Single submitter
- ARHGEF11 p.Asp641Asn Uncertain significance Single submitter
- ARHGEF11 p.Asp739Gly Uncertain significance Single submitter
- ARHGEF11 p.Gln1177His Uncertain significance Single submitter
- ARHGEF11 p.Gln133His Uncertain significance Single submitter
- ARHGEF11 p.Gln1437Pro Uncertain significance Single submitter
- ARHGEF11 p.Gln754Glu Uncertain significance Single submitter
- ARHGEF11 p.Glu1271Gln Uncertain significance Single submitter
- ARHGEF11 p.Glu1536Gly Uncertain significance Single submitter
- ARHGEF11 p.Glu192Asp Uncertain significance Single submitter
- ARHGEF11 p.Glu258Asp Uncertain significance Single submitter
- ARHGEF11 p.Glu646Lys Uncertain significance Single submitter
- ARHGEF11 p.Gly1054Val Uncertain significance Single submitter
- ARHGEF11 p.Gly1126Arg Uncertain significance Single submitter
- ARHGEF11 p.Gly1171Arg Uncertain significance Single submitter
- ARHGEF11 p.Gly1291Val Uncertain significance Single submitter
- ARHGEF11 p.Gly1294Val Uncertain significance Single submitter
- ARHGEF11 p.Gly1432Glu Uncertain significance Single submitter
- ARHGEF11 p.Gly1494Arg Uncertain significance Single submitter
- ARHGEF11 p.Gly1500Ala Uncertain significance Single submitter
- ARHGEF11 p.Gly322Asp Uncertain significance Single submitter
- ARHGEF11 p.Gly716Ser Uncertain significance Single submitter
- ARHGEF11 p.Gly843Ser Uncertain significance Single submitter
- ARHGEF11 p.Gly94Ser Uncertain significance Single submitter
- ARHGEF11 p.His1250Arg Uncertain significance Single submitter
- ARHGEF11 p.His611Arg Uncertain significance Single submitter
- ARHGEF11 p.Ile1085Val Uncertain significance Single submitter
- ARHGEF11 p.Ile298Thr Uncertain significance Single submitter
- ARHGEF11 p.Ile298Val Uncertain significance Single submitter
- ARHGEF11 p.Ile371Val Uncertain significance Single submitter
- ARHGEF11 p.Ile407Phe Uncertain significance Single submitter
- ARHGEF11 p.Ile9Thr Uncertain significance Single submitter
- ARHGEF11 p.Leu1186Val Uncertain significance Single submitter
- ARHGEF11 p.Leu1274Arg Uncertain significance Single submitter
- ARHGEF11 p.Leu169Pro Uncertain significance Single submitter
- ARHGEF11 p.Leu254Pro Uncertain significance Single submitter
- ARHGEF11 p.Leu732Phe Uncertain significance Single submitter
- ARHGEF11 p.Leu957Val Uncertain significance Single submitter
- ARHGEF11 p.Lys1090Arg Uncertain significance Single submitter
- ARHGEF11 p.Lys328Thr Uncertain significance Single submitter
- ARHGEF11 p.Lys411Glu Uncertain significance Single submitter
- ARHGEF11 p.Lys538Asn Uncertain significance Single submitter
- ARHGEF11 p.Lys554Glu Uncertain significance Single submitter
- ARHGEF11 p.Met1464Val Uncertain significance Single submitter
- ARHGEF11 p.Met278Val Uncertain significance Single submitter
- ARHGEF11 p.Met449Ile Uncertain significance Single submitter
- ARHGEF11 p.Met520Val Uncertain significance Single submitter
- ARHGEF11 p.Phe1507Ser Uncertain significance Single submitter
- ARHGEF11 p.Phe1507Tyr Uncertain significance Single submitter
- ARHGEF11 p.Pro1278Ala Uncertain significance Single submitter
- ARHGEF11 p.Pro1278Thr Uncertain significance Single submitter
- ARHGEF11 p.Pro1297Thr Uncertain significance Single submitter
- ARHGEF11 p.Pro1329His Uncertain significance Single submitter
- ARHGEF11 p.Pro136Thr Uncertain significance Single submitter
- ARHGEF11 p.Pro1409Ser Uncertain significance Single submitter
- ARHGEF11 p.Pro1426Thr Uncertain significance Single submitter
- ARHGEF11 p.Pro142Ser Uncertain significance Single submitter
- ARHGEF11 p.Pro1430Leu Uncertain significance Single submitter
- ARHGEF11 p.Pro1526Leu Uncertain significance Single submitter
- ARHGEF11 p.Pro160Ser Uncertain significance Single submitter
- ARHGEF11 p.Pro340Leu Uncertain significance Single submitter
- ARHGEF11 p.Pro34Ser Uncertain significance Single submitter
- ARHGEF11 p.Pro820Leu Uncertain significance Single submitter
- ARHGEF11 p.Ser1055Pro Uncertain significance Single submitter
- ARHGEF11 p.Ser276Thr Uncertain significance Single submitter
- ARHGEF11 p.Ser469Arg Uncertain significance Single submitter
- ARHGEF11 p.Ser596Phe Uncertain significance Single submitter
- ARHGEF11 p.Ser850Gly Uncertain significance Single submitter
- ARHGEF11 p.Thr1261Ala Uncertain significance Single submitter
- ARHGEF11 p.Thr1473Ala Uncertain significance Single submitter
- ARHGEF11 p.Thr1473Ile Uncertain significance Single submitter
- ARHGEF11 p.Thr243Ala Uncertain significance Single submitter
- ARHGEF11 p.Thr41Ala Uncertain significance Single submitter
- ARHGEF11 p.Tyr1097Cys Uncertain significance Single submitter
- ARHGEF11 p.Val1362Ile Uncertain significance Single submitter
- ARHGEF11 p.Val1368Glu Uncertain significance Single submitter
- ARHGEF11 p.Val1390Gly Uncertain significance Single submitter
Predictors split 57
The independent predictors disagree with each other — read with care.
- ARHGEF11 p.Ala1101Ser Uncertain significance Single submitter
- ARHGEF11 p.Ala113Val Uncertain significance Single submitter
- ARHGEF11 p.Arg1314Trp Uncertain significance Single submitter
- ARHGEF11 p.Arg162Cys Uncertain significance Single submitter
- ARHGEF11 p.Arg251Gln Uncertain significance Single submitter
- ARHGEF11 p.Arg25Cys Uncertain significance Single submitter
- ARHGEF11 p.Arg308Gln Uncertain significance Single submitter
- ARHGEF11 p.Arg430His Uncertain significance Single submitter
- ARHGEF11 p.Arg432Trp Uncertain significance Single submitter
- ARHGEF11 p.Arg438Gly Uncertain significance Single submitter
- ARHGEF11 p.Arg485Gln Uncertain significance Single submitter
- ARHGEF11 p.Arg771Trp Uncertain significance Single submitter
- ARHGEF11 p.Arg803Gln Uncertain significance Single submitter
- ARHGEF11 p.Arg840Gln Uncertain significance Single submitter
- ARHGEF11 p.Arg856Trp Uncertain significance Single submitter
- ARHGEF11 p.Arg950Gln Uncertain significance Single submitter
- ARHGEF11 p.Arg970Gly Uncertain significance Single submitter
- ARHGEF11 p.Arg972His Uncertain significance Single submitter
- ARHGEF11 p.Asp353Asn Uncertain significance Single submitter
- ARHGEF11 p.Glu1263Lys Uncertain significance Single submitter
- ARHGEF11 p.Glu1271Lys Uncertain significance Single submitter
- ARHGEF11 p.Glu435Lys Uncertain significance Single submitter
- ARHGEF11 p.Glu995Gly Uncertain significance Single submitter
- ARHGEF11 p.Gly1443Cys Uncertain significance Single submitter
- ARHGEF11 p.Gly1495Val Uncertain significance Single submitter
- ARHGEF11 p.Gly262Cys Uncertain significance Single submitter
- ARHGEF11 p.Gly631Arg Uncertain significance Single submitter
- ARHGEF11 p.Gly767Val Uncertain significance Single submitter
- ARHGEF11 p.His1327Tyr Uncertain significance Single submitter
- ARHGEF11 p.Ile647Thr Uncertain significance Single submitter
- ARHGEF11 p.Leu1307Phe Uncertain significance Single submitter
- ARHGEF11 p.Leu364Val Uncertain significance Single submitter
- ARHGEF11 p.Lys110Arg Uncertain significance Single submitter
- ARHGEF11 p.Phe372Leu Uncertain significance Single submitter
- ARHGEF11 p.Pro1424His Uncertain significance Single submitter
- ARHGEF11 p.Pro156Leu Uncertain significance Single submitter
- ARHGEF11 p.Pro166His Uncertain significance Single submitter
- ARHGEF11 p.Pro597Thr Uncertain significance Single submitter
- ARHGEF11 p.Pro74Ala Uncertain significance Single submitter
- ARHGEF11 p.Pro860Ser Uncertain significance Single submitter
- ARHGEF11 p.Ser1255Asn Uncertain significance Single submitter
- ARHGEF11 p.Ser1292Phe Uncertain significance Single submitter
- ARHGEF11 p.Ser1371Ile Uncertain significance Single submitter
- ARHGEF11 p.Ser1404Arg Uncertain significance Single submitter
- ARHGEF11 p.Ser1453Phe Uncertain significance Single submitter
- ARHGEF11 p.Ser253Cys Uncertain significance Single submitter
- ARHGEF11 p.Ser29Cys Uncertain significance Single submitter
- ARHGEF11 p.Ser378Gly Uncertain significance Single submitter
- ARHGEF11 p.Ser559Asn Uncertain significance Single submitter
- ARHGEF11 p.Ser698Asn Uncertain significance Single submitter
- ARHGEF11 p.Ser719Arg Uncertain significance Single submitter
- ARHGEF11 p.Thr1468Asn Uncertain significance Single submitter
- ARHGEF11 p.Thr1502Met Uncertain significance Single submitter
- ARHGEF11 p.Thr729Ile Uncertain significance Single submitter
- ARHGEF11 p.Trp1338Cys Uncertain significance Single submitter
- ARHGEF11 p.Val1118Met Uncertain significance Single submitter
- ARHGEF11 p.Val366Ala Uncertain significance Single submitter
All ARHGEF11 variants
Benign 1
- p.Gln45= Single submitter
Likely benign 11
- c.4193-6G>C Single submitter
- p.Ala1523Thr Single submitter
- p.Arg46= Single submitter
- p.Gln1268Arg Single submitter
- p.Gly1146Ser Single submitter
- p.Gly319Ser Single submitter
- p.Pro1410Leu Single submitter
- p.Pro1450Leu Single submitter
- p.Ser509= Single submitter
- p.Val1283Ile Single submitter
- p.Val765= Single submitter
Uncertain significance 163
- p.Ala1101Ser Single submitter ⚠
- p.Ala1127Asp Single submitter ⚠
- p.Ala1128Thr Single submitter ⚠
- p.Ala113Thr Single submitter ⚠
- p.Ala113Val Single submitter ⚠
- p.Ala1143Thr Single submitter ⚠
- p.Ala1485Thr Single submitter ⚠
- p.Ala1547Gly Single submitter ⚠
- p.Ala539Thr Single submitter ⚠
- p.Ala683Val Single submitter ⚠
- p.Ala988Thr Single submitter ⚠
- p.Arg1119Gln Single submitter ⚠
- p.Arg1178Lys Single submitter ⚠
- p.Arg1314Trp Single submitter ⚠
- p.Arg143Gln Single submitter ⚠
- p.Arg1449Cys Single submitter ⚠
- p.Arg1452His Single submitter ⚠
- p.Arg1460Gly Single submitter ⚠
- p.Arg162Cys Single submitter ⚠
- p.Arg251Gln Single submitter ⚠
- p.Arg25Cys Single submitter ⚠
- p.Arg308Gln Single submitter ⚠
- p.Arg430His Single submitter ⚠
- p.Arg432Trp Single submitter ⚠
- p.Arg438Gly Single submitter ⚠
- p.Arg46His Single submitter ⚠
- p.Arg485Gln Single submitter ⚠
- p.Arg528Gln Single submitter ⚠
- p.Arg644His Single submitter ⚠
- p.Arg648Leu Single submitter ⚠
- p.Arg771Trp Single submitter ⚠
- p.Arg803Gln Single submitter ⚠
- p.Arg817Gln Single submitter ⚠
- p.Arg840Gln Single submitter ⚠
- p.Arg856Gln Single submitter ⚠
- p.Arg856Trp Single submitter ⚠
- p.Arg888His Single submitter ⚠
- p.Arg948Gln Single submitter ⚠
- p.Arg950Gln Single submitter ⚠
- p.Arg950Trp Single submitter ⚠
- p.Arg970Gly Single submitter ⚠
- p.Arg972His Single submitter ⚠
- p.Asn1444Lys Single submitter ⚠
- p.Asn560Ser Single submitter ⚠
- p.Asn604Ser Single submitter ⚠
- p.Asp1239Glu Single submitter ⚠
- p.Asp1445Asn Single submitter ⚠
- p.Asp353Asn Single submitter ⚠
- p.Asp53Gly Single submitter ⚠
- p.Asp641Asn Single submitter ⚠
- p.Asp739Gly Single submitter ⚠
- p.Gln1177His Single submitter ⚠
- p.Gln133His Single submitter ⚠
- p.Gln1437Pro Single submitter ⚠
- p.Gln754Glu Single submitter ⚠
- p.Glu1263Lys Single submitter ⚠
- p.Glu1271Gln Single submitter ⚠
- p.Glu1271Lys Single submitter ⚠
- p.Glu1536Gly Single submitter ⚠
- p.Glu192Asp Single submitter ⚠
- p.Glu258Asp Single submitter ⚠
- p.Glu435Lys Single submitter ⚠
- p.Glu646Lys Single submitter ⚠
- p.Glu995Gly Single submitter ⚠
- p.Gly1054Val Single submitter ⚠
- p.Gly1126Arg Single submitter ⚠
- p.Gly1171Arg Single submitter ⚠
- p.Gly1291Val Single submitter ⚠
- p.Gly1294Val Single submitter ⚠
- p.Gly1432Glu Single submitter ⚠
- p.Gly1443Cys Single submitter ⚠
- p.Gly1494Arg Single submitter ⚠
- p.Gly1495Val Single submitter ⚠
- p.Gly1500Ala Single submitter ⚠
- p.Gly262Cys Single submitter ⚠
- p.Gly322Asp Single submitter ⚠
- p.Gly631Arg Single submitter ⚠
- p.Gly716Ser Single submitter ⚠
- p.Gly767Val Single submitter ⚠
- p.Gly843Ser Single submitter ⚠
- p.Gly94Ser Single submitter ⚠
- p.His1250Arg Single submitter ⚠
- p.His1327Tyr Single submitter ⚠
- p.His611Arg Single submitter ⚠
- p.Ile1085Val Single submitter ⚠
- p.Ile298Thr Single submitter ⚠
- p.Ile298Val Single submitter ⚠
- p.Ile371Val Single submitter ⚠
- p.Ile407Phe Single submitter ⚠
- p.Ile647Thr Single submitter ⚠
- p.Ile9Thr Single submitter ⚠
- p.Leu1186Val Single submitter ⚠
- p.Leu1274Arg Single submitter ⚠
- p.Leu1307Phe Single submitter ⚠
- p.Leu169Pro Single submitter ⚠
- p.Leu254Pro Single submitter ⚠
- p.Leu364Val Single submitter ⚠
- p.Leu732Phe Single submitter ⚠
- p.Leu957Val Single submitter ⚠
- p.Lys1090Arg Single submitter ⚠
- p.Lys110Arg Single submitter ⚠
- p.Lys328Thr Single submitter ⚠
- p.Lys411Glu Single submitter ⚠
- p.Lys538Asn Single submitter ⚠
- p.Lys554Glu Single submitter ⚠
- p.Met1464Val Single submitter ⚠
- p.Met278Val Single submitter ⚠
- p.Met449Ile Single submitter ⚠
- p.Met520Val Single submitter ⚠
- p.Phe1507Ser Single submitter ⚠
- p.Phe1507Tyr Single submitter ⚠
- p.Phe372Leu Single submitter ⚠
- p.Pro1278Ala Single submitter ⚠
- p.Pro1278Thr Single submitter ⚠
- p.Pro1297Thr Single submitter ⚠
- p.Pro1329His Single submitter ⚠
- p.Pro136Thr Single submitter ⚠
- p.Pro1409Ser Single submitter ⚠
- p.Pro1424His Single submitter ⚠
- p.Pro1426Thr Single submitter ⚠
- p.Pro142Ser Single submitter ⚠
- p.Pro1430Leu Single submitter ⚠
- p.Pro1526Leu Single submitter ⚠
- p.Pro156Leu Single submitter ⚠
- p.Pro160Ser Single submitter ⚠
- p.Pro166His Single submitter ⚠
- p.Pro340Leu Single submitter ⚠
- p.Pro34Ser Single submitter ⚠
- p.Pro597Thr Single submitter ⚠
- p.Pro74Ala Single submitter ⚠
- p.Pro820Leu Single submitter ⚠
- p.Pro860Ser Single submitter ⚠
- p.Ser1055Pro Single submitter ⚠
- p.Ser1255Asn Single submitter ⚠
- p.Ser1292Phe Single submitter ⚠
- p.Ser1371Ile Single submitter ⚠
- p.Ser1404Arg Single submitter ⚠
- p.Ser1453Phe Single submitter ⚠
- p.Ser253Cys Single submitter ⚠
- p.Ser276Thr Single submitter ⚠
- p.Ser29Cys Single submitter ⚠
- p.Ser378Gly Single submitter ⚠
- p.Ser469Arg Single submitter ⚠
- p.Ser559Asn Single submitter ⚠
- p.Ser596Phe Single submitter ⚠
- p.Ser698Asn Single submitter ⚠
- p.Ser719Arg Single submitter ⚠
- p.Ser850Gly Single submitter ⚠
- p.Thr1261Ala Single submitter ⚠
- p.Thr1468Asn Single submitter ⚠
- p.Thr1473Ala Single submitter ⚠
- p.Thr1473Ile Single submitter ⚠
- p.Thr1502Met Single submitter ⚠
- p.Thr243Ala Single submitter ⚠
- p.Thr41Ala Single submitter ⚠
- p.Thr729Ile Single submitter ⚠
- p.Trp1338Cys Single submitter ⚠
- p.Tyr1097Cys Single submitter ⚠
- p.Val1118Met Single submitter ⚠
- p.Val1362Ile Single submitter ⚠
- p.Val1368Glu Single submitter ⚠
- p.Val1390Gly Single submitter ⚠
- p.Val366Ala Single submitter ⚠