ARHGEF16 — 123 ClinVar variants
All ClinVar germline ARHGEF16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
3 Benign · 9 Likely benign · 111 Uncertain significance
Full ARHGEF16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 68
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGEF16 p.Ala156Val Uncertain significance Single submitter
- ARHGEF16 p.Ala352Asp Uncertain significance Single submitter
- ARHGEF16 p.Ala49Thr Uncertain significance Single submitter
- ARHGEF16 p.Ala642Val Uncertain significance Single submitter
- ARHGEF16 p.Ala684Ser Uncertain significance Single submitter
- ARHGEF16 p.Ala79Val Uncertain significance Single submitter
- ARHGEF16 p.Ala99Val Uncertain significance Single submitter
- ARHGEF16 p.Arg155Gln Uncertain significance Single submitter
- ARHGEF16 p.Arg190Gln Uncertain significance Single submitter
- ARHGEF16 p.Arg222Gln Uncertain significance Single submitter
- ARHGEF16 p.Arg222Gly Uncertain significance Single submitter
- ARHGEF16 p.Arg24Gln Uncertain significance Single submitter
- ARHGEF16 p.Arg257Gln Uncertain significance Single submitter
- ARHGEF16 p.Arg317Leu Uncertain significance Single submitter
- ARHGEF16 p.Arg399Gln Uncertain significance Single submitter
- ARHGEF16 p.Arg39His Uncertain significance Single submitter
- ARHGEF16 p.Arg518Gln Uncertain significance Single submitter
- ARHGEF16 p.Arg610Gln Uncertain significance Single submitter
- ARHGEF16 p.Arg704Gln Uncertain significance Single submitter
- ARHGEF16 p.Asn148Lys Uncertain significance Single submitter
- ARHGEF16 p.Asn30Ser Uncertain significance Single submitter
- ARHGEF16 p.Asn532Lys Uncertain significance Single submitter
- ARHGEF16 p.Asp47Gly Uncertain significance Single submitter
- ARHGEF16 p.Asp673Val Uncertain significance Single submitter
- ARHGEF16 p.Gln220Glu Uncertain significance Single submitter
- ARHGEF16 p.Gln389Lys Uncertain significance Single submitter
- ARHGEF16 p.Gln464Lys Uncertain significance Single submitter
- ARHGEF16 p.Gln584Arg Uncertain significance Single submitter
- ARHGEF16 p.Gln595Glu Uncertain significance Single submitter
- ARHGEF16 p.Gln597Arg Uncertain significance Single submitter
- ARHGEF16 p.Glu271Lys Uncertain significance Single submitter
- ARHGEF16 p.Glu291Lys Uncertain significance Single submitter
- ARHGEF16 p.Glu344Gln Uncertain significance Single submitter
- ARHGEF16 p.Glu365Lys Uncertain significance Single submitter
- ARHGEF16 p.Glu368Gln Uncertain significance Single submitter
- ARHGEF16 p.Glu404Asp Uncertain significance Single submitter
- ARHGEF16 p.Glu592Gln Uncertain significance Single submitter
- ARHGEF16 p.Glu647Lys Uncertain significance Single submitter
- ARHGEF16 p.Glu76Ala Uncertain significance Single submitter
- ARHGEF16 p.Gly142Arg Uncertain significance Single submitter
- ARHGEF16 p.Gly162Glu Uncertain significance Single submitter
- ARHGEF16 p.Gly168Glu Uncertain significance Single submitter
- ARHGEF16 p.Gly28Arg Uncertain significance Single submitter
- ARHGEF16 p.Gly29Arg Uncertain significance Single submitter
- ARHGEF16 p.Gly34Arg Uncertain significance Single submitter
- ARHGEF16 p.His205Arg Uncertain significance Single submitter
- ARHGEF16 p.Ile362Val Uncertain significance Single submitter
- ARHGEF16 p.Leu493Phe Uncertain significance Single submitter
- ARHGEF16 p.Leu81Val Uncertain significance Single submitter
- ARHGEF16 p.Lys460Gln Uncertain significance Single submitter
- ARHGEF16 p.Met416Thr Uncertain significance Single submitter
- ARHGEF16 p.Met478Leu Uncertain significance Single submitter
- ARHGEF16 p.Phe398Ser Uncertain significance Single submitter
- ARHGEF16 p.Pro141Leu Uncertain significance Single submitter
- ARHGEF16 p.Pro192Leu Uncertain significance Single submitter
- ARHGEF16 p.Pro568His Uncertain significance Single submitter
- ARHGEF16 p.Pro57Leu Uncertain significance Single submitter
- ARHGEF16 p.Pro63Ser Uncertain significance Single submitter
- ARHGEF16 p.Pro70Ser Uncertain significance Single submitter
- ARHGEF16 p.Ser240Thr Uncertain significance Single submitter
- ARHGEF16 p.Ser255Thr Uncertain significance Single submitter
- ARHGEF16 p.Ser295Leu Uncertain significance Single submitter
- ARHGEF16 p.Ser298Phe Uncertain significance Single submitter
- ARHGEF16 p.Ser74Gly Uncertain significance Single submitter
- ARHGEF16 p.Thr676Met Uncertain significance Single submitter
- ARHGEF16 p.Tyr479His Uncertain significance Single submitter
- ARHGEF16 p.Val559Glu Uncertain significance Single submitter
- ARHGEF16 p.Val613Ala Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- ARHGEF16 p.Ala367Ser Uncertain significance Single submitter
- ARHGEF16 p.Ala367Thr Uncertain significance Single submitter
- ARHGEF16 p.Ala498Val Uncertain significance Single submitter
- ARHGEF16 p.Ala552Thr Uncertain significance Single submitter
- ARHGEF16 p.Ala614Val Uncertain significance Single submitter
- ARHGEF16 p.Arg119Trp Uncertain significance Single submitter
- ARHGEF16 p.Arg155Trp Uncertain significance Single submitter
- ARHGEF16 p.Arg18Cys Uncertain significance Single submitter
- ARHGEF16 p.Arg18His Uncertain significance Single submitter
- ARHGEF16 p.Arg257Trp Uncertain significance Single submitter
- ARHGEF16 p.Arg317Trp Uncertain significance Single submitter
- ARHGEF16 p.Arg349Gln Uncertain significance Single submitter
- ARHGEF16 p.Arg349Trp Uncertain significance Single submitter
- ARHGEF16 p.Arg4Gln Uncertain significance Single submitter
- ARHGEF16 p.Arg505Cys Uncertain significance Single submitter
- ARHGEF16 p.Arg575Cys Uncertain significance Single submitter
- ARHGEF16 p.Arg61Trp Uncertain significance Single submitter
- ARHGEF16 p.Arg685Gly Uncertain significance Single submitter
- ARHGEF16 p.Arg685His Uncertain significance Single submitter
- ARHGEF16 p.Asp236Asn Uncertain significance Single submitter
- ARHGEF16 p.Asp533Asn Uncertain significance Single submitter
- ARHGEF16 p.Glu237Lys Uncertain significance Single submitter
- ARHGEF16 p.Glu281Gly Uncertain significance Single submitter
- ARHGEF16 p.Glu635Lys Uncertain significance Single submitter
- ARHGEF16 p.Gly207Asp Uncertain significance Single submitter
- ARHGEF16 p.Gly674Arg Uncertain significance Single submitter
- ARHGEF16 p.His327Tyr Uncertain significance Single submitter
- ARHGEF16 p.Ile687Val Uncertain significance Single submitter
- ARHGEF16 p.Leu346Val Uncertain significance Single submitter
- ARHGEF16 p.Leu567Ile Uncertain significance Single submitter
- ARHGEF16 p.Leu598Phe Uncertain significance Single submitter
- ARHGEF16 p.Leu615Phe Uncertain significance Single submitter
- ARHGEF16 p.Lys314Arg Likely benign Single submitter
- ARHGEF16 p.Met289Thr Uncertain significance Single submitter
- ARHGEF16 p.Pro267Ser Uncertain significance Single submitter
- ARHGEF16 p.Ser131Tyr Uncertain significance Single submitter
- ARHGEF16 p.Ser394Ile Uncertain significance Single submitter
- ARHGEF16 p.Ser499Cys Uncertain significance Single submitter
- ARHGEF16 p.Ser602Leu Uncertain significance Single submitter
- ARHGEF16 p.Ser626Cys Uncertain significance Single submitter
- ARHGEF16 p.Thr525Met Uncertain significance Single submitter
- ARHGEF16 p.Val307Met Uncertain significance Single submitter
- ARHGEF16 p.Val536Phe Uncertain significance Single submitter
- ARHGEF16 p.Val559Ala Uncertain significance Single submitter
- ARHGEF16 p.Val579Met Likely benign Single submitter
All ARHGEF16 variants
Benign 3
- p.Ala318= Multiple submitters
- p.Met547Thr Multiple submitters
- c.1888+9G>A Single submitter
Likely benign 9
- p.Ala27= Single submitter
- p.Arg341= Single submitter
- p.Arg463Lys Single submitter
- p.Lys314Arg Single submitter ⚠
- p.Pro42Leu Single submitter
- p.Ser304Gly Single submitter
- p.Ser393Asn Single submitter
- p.Thr514= Single submitter
- p.Val579Met Single submitter ⚠
Uncertain significance 111
- p.Ala156Val Single submitter ⚠
- p.Ala352Asp Single submitter ⚠
- p.Ala367Ser Single submitter ⚠
- p.Ala367Thr Single submitter ⚠
- p.Ala498Val Single submitter ⚠
- p.Ala49Thr Single submitter ⚠
- p.Ala552Thr Single submitter ⚠
- p.Ala614Val Single submitter ⚠
- p.Ala642Val Single submitter ⚠
- p.Ala684Ser Single submitter ⚠
- p.Ala79Val Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Arg119Trp Single submitter ⚠
- p.Arg155Gln Single submitter ⚠
- p.Arg155Trp Single submitter ⚠
- p.Arg18Cys Single submitter ⚠
- p.Arg18His Single submitter ⚠
- p.Arg190Gln Single submitter ⚠
- p.Arg222Gln Single submitter ⚠
- p.Arg222Gly Single submitter ⚠
- p.Arg24Gln Single submitter ⚠
- p.Arg257Gln Single submitter ⚠
- p.Arg257Trp Single submitter ⚠
- p.Arg317Leu Single submitter ⚠
- p.Arg317Trp Single submitter ⚠
- p.Arg349Gln Single submitter ⚠
- p.Arg349Trp Single submitter ⚠
- p.Arg399Gln Single submitter ⚠
- p.Arg39His Single submitter ⚠
- p.Arg4Gln Single submitter ⚠
- p.Arg505Cys Single submitter ⚠
- p.Arg518Gln Single submitter ⚠
- p.Arg575Cys Single submitter ⚠
- p.Arg610Gln Single submitter ⚠
- p.Arg61Trp Single submitter ⚠
- p.Arg685Gly Single submitter ⚠
- p.Arg685His Single submitter ⚠
- p.Arg704Gln Single submitter ⚠
- p.Asn148Lys Single submitter ⚠
- p.Asn30Ser Single submitter ⚠
- p.Asn532Lys Single submitter ⚠
- p.Asp236Asn Single submitter ⚠
- p.Asp47Gly Single submitter ⚠
- p.Asp533Asn Single submitter ⚠
- p.Asp673Val Single submitter ⚠
- p.Gln220Glu Single submitter ⚠
- p.Gln389Lys Single submitter ⚠
- p.Gln464Lys Single submitter ⚠
- p.Gln584Arg Single submitter ⚠
- p.Gln595Glu Single submitter ⚠
- p.Gln597Arg Single submitter ⚠
- p.Glu237Lys Single submitter ⚠
- p.Glu271Lys Single submitter ⚠
- p.Glu281Gly Single submitter ⚠
- p.Glu291Lys Single submitter ⚠
- p.Glu344Gln Single submitter ⚠
- p.Glu365Lys Single submitter ⚠
- p.Glu368Gln Single submitter ⚠
- p.Glu404Asp Single submitter ⚠
- p.Glu592Gln Single submitter ⚠
- p.Glu635Lys Single submitter ⚠
- p.Glu647Lys Single submitter ⚠
- p.Glu76Ala Single submitter ⚠
- p.Gly142Arg Single submitter ⚠
- p.Gly162Glu Single submitter ⚠
- p.Gly168Glu Single submitter ⚠
- p.Gly207Asp Single submitter ⚠
- p.Gly28Arg Single submitter ⚠
- p.Gly29Arg Single submitter ⚠
- p.Gly34Arg Single submitter ⚠
- p.Gly674Arg Single submitter ⚠
- p.His205Arg Single submitter ⚠
- p.His327Tyr Single submitter ⚠
- p.Ile362Val Single submitter ⚠
- p.Ile687Val Single submitter ⚠
- p.Leu346Val Single submitter ⚠
- p.Leu493Phe Single submitter ⚠
- p.Leu567Ile Single submitter ⚠
- p.Leu598Phe Single submitter ⚠
- p.Leu615Phe Single submitter ⚠
- p.Leu81Val Single submitter ⚠
- p.Lys460Gln Single submitter ⚠
- p.Met289Thr Single submitter ⚠
- p.Met416Thr Single submitter ⚠
- p.Met478Leu Single submitter ⚠
- p.Phe398Ser Single submitter ⚠
- p.Pro141Leu Single submitter ⚠
- p.Pro192Leu Single submitter ⚠
- p.Pro267Ser Single submitter ⚠
- p.Pro568His Single submitter ⚠
- p.Pro57Leu Single submitter ⚠
- p.Pro63Ser Single submitter ⚠
- p.Pro70Ser Single submitter ⚠
- p.Ser131Tyr Single submitter ⚠
- p.Ser240Thr Single submitter ⚠
- p.Ser255Thr Single submitter ⚠
- p.Ser295Leu Single submitter ⚠
- p.Ser298Phe Single submitter ⚠
- p.Ser394Ile Single submitter ⚠
- p.Ser499Cys Single submitter ⚠
- p.Ser602Leu Single submitter ⚠
- p.Ser626Cys Single submitter ⚠
- p.Ser74Gly Single submitter ⚠
- p.Thr525Met Single submitter ⚠
- p.Thr676Met Single submitter ⚠
- p.Tyr479His Single submitter ⚠
- p.Val307Met Single submitter ⚠
- p.Val536Phe Single submitter ⚠
- p.Val559Ala Single submitter ⚠
- p.Val559Glu Single submitter ⚠
- p.Val613Ala Single submitter ⚠