ARHGEF19 — 126 ClinVar variants
All ClinVar germline ARHGEF19 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 117 flagged for review →
1 Benign/Likely benign · 7 Likely benign · 118 Uncertain significance
Full ARHGEF19 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 117
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 95
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGEF19 p.Ala108Val Uncertain significance Single submitter
- ARHGEF19 p.Ala112Pro Uncertain significance Single submitter
- ARHGEF19 p.Ala137Pro Uncertain significance Single submitter
- ARHGEF19 p.Ala157Ser Uncertain significance Single submitter
- ARHGEF19 p.Ala217Thr Uncertain significance Single submitter
- ARHGEF19 p.Ala343Glu Uncertain significance Single submitter
- ARHGEF19 p.Ala368Pro Uncertain significance Single submitter
- ARHGEF19 p.Arg126His Uncertain significance Single submitter
- ARHGEF19 p.Arg142Gln Uncertain significance Single submitter
- ARHGEF19 p.Arg194Lys Uncertain significance Single submitter
- ARHGEF19 p.Arg210His Uncertain significance Single submitter
- ARHGEF19 p.Arg240Gln Uncertain significance Single submitter
- ARHGEF19 p.Arg240Leu Uncertain significance Single submitter
- ARHGEF19 p.Arg240Pro Uncertain significance Single submitter
- ARHGEF19 p.Arg284Leu Uncertain significance Single submitter
- ARHGEF19 p.Arg287Gln Uncertain significance Single submitter
- ARHGEF19 p.Arg332Leu Uncertain significance Single submitter
- ARHGEF19 p.Arg332Pro Uncertain significance Single submitter
- ARHGEF19 p.Arg348Gly Uncertain significance Single submitter
- ARHGEF19 p.Arg373Gln Uncertain significance Single submitter
- ARHGEF19 p.Arg463His Uncertain significance Single submitter
- ARHGEF19 p.Arg489Ser Uncertain significance Single submitter
- ARHGEF19 p.Arg521Cys Uncertain significance Single submitter
- ARHGEF19 p.Arg521Gly Uncertain significance Single submitter
- ARHGEF19 p.Arg64Cys Uncertain significance Single submitter
- ARHGEF19 p.Arg64His Uncertain significance Single submitter
- ARHGEF19 p.Arg685Gln Uncertain significance Single submitter
- ARHGEF19 p.Arg685Trp Uncertain significance Single submitter
- ARHGEF19 p.Arg687Trp Uncertain significance Single submitter
- ARHGEF19 p.Arg757His Uncertain significance Single submitter
- ARHGEF19 p.Asn548Ser Uncertain significance Single submitter
- ARHGEF19 p.Asn787Lys Uncertain significance Single submitter
- ARHGEF19 p.Asn787Ser Uncertain significance Single submitter
- ARHGEF19 p.Asp268Asn Uncertain significance Single submitter
- ARHGEF19 p.Asp374Ala Uncertain significance Single submitter
- ARHGEF19 p.Asp49His Uncertain significance Single submitter
- ARHGEF19 p.Asp707Gly Uncertain significance Single submitter
- ARHGEF19 p.Asp732Gly Uncertain significance Single submitter
- ARHGEF19 p.Cys105Ser Uncertain significance Single submitter
- ARHGEF19 p.Cys557Arg Uncertain significance Single submitter
- ARHGEF19 p.Cys717Tyr Uncertain significance Single submitter
- ARHGEF19 p.Gln562Arg Uncertain significance Single submitter
- ARHGEF19 p.Gln74Arg Uncertain significance Single submitter
- ARHGEF19 p.Glu148Val Uncertain significance Single submitter
- ARHGEF19 p.Glu154Asp Uncertain significance Single submitter
- ARHGEF19 p.Glu175Lys Uncertain significance Single submitter
- ARHGEF19 p.Glu282Val Uncertain significance Single submitter
- ARHGEF19 p.Glu30Asp Uncertain significance Single submitter
- ARHGEF19 p.Glu325Asp Uncertain significance Single submitter
- ARHGEF19 p.Glu36Asp Uncertain significance Single submitter
- ARHGEF19 p.Glu443Val Uncertain significance Single submitter
- ARHGEF19 p.Glu88Lys Uncertain significance Single submitter
- ARHGEF19 p.Gly131Ser Uncertain significance Single submitter
- ARHGEF19 p.Gly151Arg Uncertain significance Single submitter
- ARHGEF19 p.Gly225Ala Uncertain significance Single submitter
- ARHGEF19 p.Gly316Val Uncertain significance Single submitter
- ARHGEF19 p.Gly349Ser Uncertain significance Single submitter
- ARHGEF19 p.Gly597Ala Uncertain significance Single submitter
- ARHGEF19 p.Gly675Arg Uncertain significance Single submitter
- ARHGEF19 p.His130Tyr Uncertain significance Single submitter
- ARHGEF19 p.His578Arg Uncertain significance Single submitter
- ARHGEF19 p.His680Tyr Uncertain significance Single submitter
- ARHGEF19 p.Ile529Val Uncertain significance Single submitter
- ARHGEF19 p.Ile711Ser Uncertain significance Single submitter
- ARHGEF19 p.Leu384Val Uncertain significance Single submitter
- ARHGEF19 p.Leu484Phe Uncertain significance Single submitter
- ARHGEF19 p.Lys233Arg Uncertain significance Single submitter
- ARHGEF19 p.Pro103Ala Uncertain significance Single submitter
- ARHGEF19 p.Pro176Arg Uncertain significance Single submitter
- ARHGEF19 p.Pro176Thr Uncertain significance Single submitter
- ARHGEF19 p.Pro191Ser Uncertain significance Single submitter
- ARHGEF19 p.Pro265Ser Uncertain significance Single submitter
- ARHGEF19 p.Pro43Leu Uncertain significance Single submitter
- ARHGEF19 p.Pro45Ala Uncertain significance Single submitter
- ARHGEF19 p.Pro610Ser Uncertain significance Single submitter
- ARHGEF19 p.Pro718Thr Uncertain significance Single submitter
- ARHGEF19 p.Ser235Ala Uncertain significance Single submitter
- ARHGEF19 p.Ser279Ile Uncertain significance Single submitter
- ARHGEF19 p.Ser336Thr Uncertain significance Single submitter
- ARHGEF19 p.Ser364Thr Uncertain significance Single submitter
- ARHGEF19 p.Ser792Asn Uncertain significance Single submitter
- ARHGEF19 p.Thr184Asn Uncertain significance Single submitter
- ARHGEF19 p.Thr184Ile Uncertain significance Single submitter
- ARHGEF19 p.Thr280Ser Uncertain significance Single submitter
- ARHGEF19 p.Thr430Ile Uncertain significance Single submitter
- ARHGEF19 p.Thr479Ser Uncertain significance Single submitter
- ARHGEF19 p.Thr69Ile Uncertain significance Single submitter
- ARHGEF19 p.Trp355Arg Uncertain significance Single submitter
- ARHGEF19 p.Tyr621Cys Uncertain significance Single submitter
- ARHGEF19 p.Val143Met Uncertain significance Single submitter
- ARHGEF19 p.Val249Leu Uncertain significance Single submitter
- ARHGEF19 p.Val366Ile Uncertain significance Single submitter
- ARHGEF19 p.Val46Ala Uncertain significance Single submitter
- ARHGEF19 p.Val644Ile Uncertain significance Single submitter
- ARHGEF19 p.Val710Ala Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- ARHGEF19 p.Ala461Val Uncertain significance Single submitter
- ARHGEF19 p.Arg204Trp Likely benign Single submitter
- ARHGEF19 p.Arg342Gly Uncertain significance Single submitter
- ARHGEF19 p.Arg496Cys Uncertain significance Single submitter
- ARHGEF19 p.Arg496His Uncertain significance Single submitter
- ARHGEF19 p.Arg518Ser Uncertain significance Single submitter
- ARHGEF19 p.Arg532Gln Uncertain significance Single submitter
- ARHGEF19 p.Arg634Trp Uncertain significance Single submitter
- ARHGEF19 p.Arg694Gln Uncertain significance Single submitter
- ARHGEF19 p.Cys375Tyr Uncertain significance Single submitter
- ARHGEF19 p.Gln481His Uncertain significance Single submitter
- ARHGEF19 p.Gly751Ala Uncertain significance Single submitter
- ARHGEF19 p.Ile358Thr Uncertain significance Single submitter
- ARHGEF19 p.Leu294Pro Uncertain significance Single submitter
- ARHGEF19 p.Met202Thr Uncertain significance Single submitter
- ARHGEF19 p.Phe434Leu Uncertain significance Single submitter
- ARHGEF19 p.Pro501Leu Uncertain significance Single submitter
- ARHGEF19 p.Ser299Asn Uncertain significance Single submitter
- ARHGEF19 p.Ser338Asn Uncertain significance Single submitter
- ARHGEF19 p.Ser338Ile Uncertain significance Single submitter
- ARHGEF19 p.Val366Asp Uncertain significance Single submitter
- ARHGEF19 p.Val642Ile Uncertain significance Single submitter
All ARHGEF19 variants
Benign/Likely benign 1
- p.Arg633Gln Multiple submitters
Likely benign 7
- c.1908-6C>T Single submitter
- p.Ala39Thr Single submitter
- p.Ala54Thr Single submitter
- p.Arg204Trp Single submitter ⚠
- p.Asp360= Single submitter
- p.Gly84Ser Single submitter
- p.Met244Thr Single submitter
Uncertain significance 118
- p.Ala108Val Single submitter ⚠
- p.Ala112Pro Single submitter ⚠
- p.Ala137Pro Single submitter ⚠
- p.Ala157Ser Single submitter ⚠
- p.Ala217Thr Single submitter ⚠
- p.Ala343Glu Single submitter ⚠
- p.Ala368Pro Single submitter ⚠
- p.Ala461Val Single submitter ⚠
- p.Arg126His Single submitter ⚠
- p.Arg142Gln Single submitter ⚠
- p.Arg194Lys Single submitter ⚠
- p.Arg210His Single submitter ⚠
- p.Arg240Gln Single submitter ⚠
- p.Arg240Leu Single submitter ⚠
- p.Arg240Pro Single submitter ⚠
- p.Arg284Leu Single submitter ⚠
- p.Arg287Gln Single submitter ⚠
- p.Arg332Leu Single submitter ⚠
- p.Arg332Pro Single submitter ⚠
- p.Arg342Gly Single submitter ⚠
- p.Arg348Gly Single submitter ⚠
- p.Arg373Gln Single submitter ⚠
- p.Arg463His Single submitter ⚠
- p.Arg489Ser Single submitter ⚠
- p.Arg496Cys Single submitter ⚠
- p.Arg496His Single submitter ⚠
- p.Arg518Ser Single submitter ⚠
- p.Arg521Cys Single submitter ⚠
- p.Arg521Gly Single submitter ⚠
- p.Arg532Gln Single submitter ⚠
- p.Arg633Trp Single submitter
- p.Arg634Trp Single submitter ⚠
- p.Arg64Cys Single submitter ⚠
- p.Arg64His Single submitter ⚠
- p.Arg685Gln Single submitter ⚠
- p.Arg685Trp Single submitter ⚠
- p.Arg687Trp Single submitter ⚠
- p.Arg694Gln Single submitter ⚠
- p.Arg757His Single submitter ⚠
- p.Asn548Ser Single submitter ⚠
- p.Asn787Lys Single submitter ⚠
- p.Asn787Ser Single submitter ⚠
- p.Asp268Asn Single submitter ⚠
- p.Asp374Ala Single submitter ⚠
- p.Asp49His Single submitter ⚠
- p.Asp707Gly Single submitter ⚠
- p.Asp732Gly Single submitter ⚠
- p.Cys105Ser Single submitter ⚠
- p.Cys375Tyr Single submitter ⚠
- p.Cys557Arg Single submitter ⚠
- p.Cys717Tyr Single submitter ⚠
- p.Gln481His Single submitter ⚠
- p.Gln562Arg Single submitter ⚠
- p.Gln74Arg Single submitter ⚠
- p.Glu148Val Single submitter ⚠
- p.Glu154Asp Single submitter ⚠
- p.Glu175Lys Single submitter ⚠
- p.Glu282Val Single submitter ⚠
- p.Glu30Asp Single submitter ⚠
- p.Glu325Asp Single submitter ⚠
- p.Glu36Asp Single submitter ⚠
- p.Glu443Val Single submitter ⚠
- p.Glu88Lys Single submitter ⚠
- p.Gly131Ser Single submitter ⚠
- p.Gly151Arg Single submitter ⚠
- p.Gly225Ala Single submitter ⚠
- p.Gly316Val Single submitter ⚠
- p.Gly349Ser Single submitter ⚠
- p.Gly597Ala Single submitter ⚠
- p.Gly662Arg Single submitter
- p.Gly675Arg Single submitter ⚠
- p.Gly751Ala Single submitter ⚠
- p.His130Tyr Single submitter ⚠
- p.His578Arg Single submitter ⚠
- p.His680Tyr Single submitter ⚠
- p.Ile358Thr Single submitter ⚠
- p.Ile529Val Single submitter ⚠
- p.Ile711Ser Single submitter ⚠
- p.Leu294Pro Single submitter ⚠
- p.Leu384Val Single submitter ⚠
- p.Leu484Phe Single submitter ⚠
- p.Lys233Arg Single submitter ⚠
- p.Met202Thr Single submitter ⚠
- p.Phe434Leu Single submitter ⚠
- p.Pro103Ala Single submitter ⚠
- p.Pro176Arg Single submitter ⚠
- p.Pro176Thr Single submitter ⚠
- p.Pro191Ser Single submitter ⚠
- p.Pro265Ser Single submitter ⚠
- p.Pro43Leu Single submitter ⚠
- p.Pro45Ala Single submitter ⚠
- p.Pro501Leu Single submitter ⚠
- p.Pro610Ser Single submitter ⚠
- p.Pro718Thr Single submitter ⚠
- p.Ser235Ala Single submitter ⚠
- p.Ser279Ile Single submitter ⚠
- p.Ser299Asn Single submitter ⚠
- p.Ser336Thr Single submitter ⚠
- p.Ser338Asn Single submitter ⚠
- p.Ser338Ile Single submitter ⚠
- p.Ser364Thr Single submitter ⚠
- p.Ser792Asn Single submitter ⚠
- p.Thr184Asn Single submitter ⚠
- p.Thr184Ile Single submitter ⚠
- p.Thr280Ser Single submitter ⚠
- p.Thr430Ile Single submitter ⚠
- p.Thr479Ser Single submitter ⚠
- p.Thr69Ile Single submitter ⚠
- p.Trp355Arg Single submitter ⚠
- p.Tyr621Cys Single submitter ⚠
- p.Val143Met Single submitter ⚠
- p.Val249Leu Single submitter ⚠
- p.Val366Asp Single submitter ⚠
- p.Val366Ile Single submitter ⚠
- p.Val46Ala Single submitter ⚠
- p.Val642Ile Single submitter ⚠
- p.Val644Ile Single submitter ⚠
- p.Val710Ala Single submitter ⚠